CAS: 52193-54-1; Pyridin-1-Ium Trifluoromethanesulfonate

相似化合物

107263-95-6 390423-43-5 130433-68-0

上下游产品

pyridine trifluorormethanesulfonic acid methyl-phenyl-thioether N-fluoropyridinium triflate3-oxo-3-phenylprop-1-en-2-yl acetate

📜吡啶,氘代三氟甲磺酸 以 二氯甲烷作为反应溶剂,反应 0.75H,以95%的收率获得duetero-Pyridinium Triflate
参考文献:[2+2+2] 甲硅烷氧基炔烃与 1,2-二嗪的环加成反应:从反应发现到抗糖酵解化学型的鉴定
标题:[2+2+2] 甲硅烷氧基炔烃与 1,2-二嗪的环加成反应:从反应发现到抗糖酵解化学型的鉴定
摘要:未发现环加成反应:在温和的反应条件下,标题反应产生了高效且具有优异非对映选择性的新型多环化合物.使用该反应合成的小分子文库产生了一种新的化学型,该化学型通过阻断 Cho-K1 细胞中的葡萄糖摄取来抑制糖酵解 Atp 的产生.Dmf= N,N-二甲基甲酰胺,Tf=三氟甲磺酰基,Tips=三异丙基甲硅烷基.
Doi:10.1002/Anie.201305711

专利信息

专利号:US-2014235850-A1
优先权日:2011-09-30
标题:Synthesis of hmo core structures
发明人：Kovács Imre; BAJZA ISTVÃ?N; HEDEROS MARKUS; DEKANY GYULA; DEMKÓ SÃ?NDOR; KHANZHIN NIKOLAY
权利人:GLYCOM AS
摘要:The invention relates to a method for making precursors of HMO core structures comprising a step of reacting an N-acetyllactosamine or lacto-N-biose derivative donor with a lactose or N-acetyllactosamine derivative acceptor, wherein the donor is an oxazoline donor.

专利号:US-2023183283-A1
优先权日:2016-10-14
标题 :Novel glycoside compound and production method therefor
发明人：OHGI TADAAKI; AOKI ERIKO; KINOSHITA TAKASHI; ITOH AKIHIRO; EMURA Chisato
权利人:BONAC CORP
摘要:The present invention aims to provide a method of producing, more efficiently at a high purity, a phosphoramidite preferable for the production (synthesis) of a nucleic acid. Using a coupling reaction of an ether represented by the following chemical formula (105), an enantiomer, tautomer or stereoisomer thereof, or a salt thereof, and a glycoside compound, phosphoramidite that enables efficient synthesis of nucleic acid can be obtained:wherein n is a positive integer, and R and R′ are the same or different and each is a hydrogen atom or a hydroxyl-protecting group.

专利号:US-11667660-B2
优先权日:2018-11-22
标题 :Pyridinium salts as activators in the synthesis of stereodefined oligonucleotides
发明人：HANSEN DENNIS JUL; FUNDER ERIK DAA
权利人:ROCHE INNOVATION CT COPENHAGEN AS
摘要:The present invention relates to a method for preparing stereodefined phosphorothioate oligonucleotides, especially locked stereodefined phosphorothioate oligonucleotides with a high yield, using pyridinium acidic salts as a coupling activator.

专利号:US-2005215801-A1
优先权日:2002-06-28
标 题 :Process for preparation of optically active 1-substituted amino-2,3-epoxypropanes, intermediates for synthesis thereof and process for preparation of the intermediates
发明人：KITAJIMA KUMI; NAGASHIMA NOBUO
权利人:KITAJIMA KUMI; NAGASHIMA NOBUO
摘要:The present invention provides an industrial process for effectively and advantageously preparing optically active 1-substituted amino-2,3-epoxypropanes useful as intermediates for preparing agricultural chemicals and medical products from optically active 1-substituted amino-2,3-propanediols used as raw materials. The present invention also provides useful intermediates. Specifically, an optically active 1-substituted amino-2,3-propanediol (1) is reacted with an orthoacid ester (2) or thionyl chloride (3) to produce a cyclic optically active compound (4), and then a compound (5) containing a halogen atom is prepared by reaction with a ring-opening reaction agent having an ability to introduce a halogen atom X. Finally, an optical active 1-substituted amino-2,3-epoxypropane is prepared by ring-closure reaction in the presence of a base.

专利号:US-6846922-B1
优先权日:1998-06-02
标题 :Activators for oligonucleotide synthesis
发明人：MANOHARAN MUTHIAH; RAVIKUMAR VASULINGA T
权利人:ISIS PHARMACEUTICALS INC
摘要:The present invention relates to improved methods for the preparation of nucleoside phosphoramidites and oligonucleotides. In one aspect, the methods of the invention are used to prepare phosphitylating reagents using pyridinium salts as activators. In a further aspect, the methods of the invention are used to prepare internucleoside linkages using activators which include at least one pyridinium salt and at least one substituted imidazole. In a further aspect, methods are provided preparation of internucleoside linkages between nucleosides having 2′-substituents using imidazolium or benzimidazolium salts as an activator. In a further aspect, methods are provided preparation of internucleoside linkages between nucleosides having bioreversible protecting group that confers enhanced chemical and biophysical properties, without exocyclic amine protection, using imidazolium or benzimidazolium salts as an activator.

专利号:EP-3883941-A1
优先权日:2018-11-22
标 题:Pyridinium salts as activators in the synthesis of stereodefined oligonucleotides