CAS: 517-97-5; Tsuduranine

📜(+)-千金藤碱置于盐酸体系中,用 溶剂黄146 作为反应溶剂,化学反应 48.0H,以4 Mg的收率获得产物土杜拉寧
参考文献:还原卟啉的立体化学
标题:还原卟啉的立体化学
摘要:通过从h-6A相对的一侧优先选择催化剂来进行前菜碱(+)-Stepharine(1)的受控催化加氢,以提供(+)-8,9-Dihydrostepharine(3),并伴随少量(-)-11,12-二氢stepharine(4)和(+)-四氢stepharine(5).nabh 4还原为5会导致(+)-α-和(+)-β-六氢stepharine(6和7).对于所有还原产物均获得了完整的光谱和光学数据,从而为还原的原卟啉生物碱的表征提供了可靠的标准.
DOI:10.1016/s0040-4020(01)81485-X

专利信息

专利号:CN-103387578-A
优先权日:2012-05-08
标题 :Synthesis of 4-p-fluorobenzyloxy-6-hydroxymorphinan

专利号:CN-103387539-A
优先权日:2012-05-08
标题:Synthesis of 4-Benzyloxy-17-acetylmorphinan-6-one

专利号:CN-103387579-A
优先权日:2012-05-08
标 题:Synthesis of 4-Benzyloxy-17-Benzenesulfonylmorphinan-6-one

专利号:US-8557837-B2
优先权日:2010-02-10
标题:Sinomenine derivatives, synthetic methods and uses thereof
发明人：YAO ZHUJUN; SUN BING; LOU YANGTONG; YANG ZHENYU; CHEN AIZHONG; MA ZHAO
权利人:YAO ZHUJUN; SUN BING; LOU YANGTONG; YANG ZHENYU; CHEN AIZHONG; MA ZHAO; SHANGHAI INST ORGANIC CHEM; SHANGHAI INST BIOL SCIENCES
摘要:The invention relates to sinomenine derivatives, methods for their synthesis and their applications. The sinomenine derivatives include oxidation derivatives, and C-10 substituted sinomenine derivatives. Based on the readily oxidizable phenol group on sinomenine structure, using oxidation, oxidative dearomatization, or conjugated addition aromatization, one can introduce C-10 substitutions to synthesize the sinomenine derivatives. The sinomenine derivatives of the invention have the following structures: n n n n n n n n n n Using in vitro TNF-α inhibition assay, the activities of the synthetic compounds are assessed. Results from these assays shown that most compounds have anti-inflammatory effects, and some compounds have better activities than that of sinomenine. These compounds may be used in treating immune diseases such as rheumatoid arthritis (RA).

专利号:CN-101798285-A
优先权日:2010-02-10
标 题:A kind of sinomenine derivative, synthesis method and application thereof

专利号:CN-101798285-B
优先权日:2010-02-10
标 题 :A kind of sinomenine derivative, synthesis method and application thereof