CAS: 4656-86-4; 3H-Imidazo[4,5-D][1,2,3]Triazin-4(7H)-One

该化合物是一个合成化合物,具有各种化学应用的巨大潜力,该化合物具有独特的结构特性,包括稳定的imidazole环和三联苯核心,有助于其多功能反应.合成可及性和独特的芳香性使它成为有机合成的宝贵组成部分,特别是在创造具有不同功能的复杂分子方面.

结构式图片

欧盟法规

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上下游产品

5-amino-1H-imidazole-4-carboxamide monohydr°Chloride 5-diazoimidazole-4-carboxamide 1-methyl-1H-imidazole-1,4-dicarboxamide5-amino-N1-methyl-1H-imidazole-1,4-dicarboxamide methanol 3-{3-[4-(3-Chloro-phenyl)-piperazin-1-yl]-propyl}-3,5-dihydro-imidazo[4,5-d][1,2,3]triazin-4-one 2-Aza-7-(2-benzoyloxyethoxymethyl)hypoxanthine 2-Aza-9-(2-benzoyloxyethoxymethyl)hypoxanthine 7-(2-Deoxy-β-D-erythro-pentafuranosyl)-7H-imidazo[4,5-d][1,2,3]triazin-4-one

合成工艺路线路线简述

    📜5-(3,3-Dimethyl-1-Triazeno)Imidazone-4-Carboxamide 以 水 作为反应溶剂,化学反应生成 1,5-二氢-4H-咪唑并[4,5-D]-1,2,3-三嗪-4-酮
    参考文献:A New Light On The Photo-Decomposition Of The Antitumour Drug Dtic
    标题:A New Light On The Photo-Decomposition Of The Antitumour Drug Dtic
    摘要:
    DOI:10.1111/j.2042-7158.1981.Tb13944.X

    专利信息


    专利号:US-7737284-B2
    优先权日:2001-01-18
    标题 :Synthesis of temozolomide and analogs
    发明人:KUO SHEN-CHUN; MAS JANET L; HOU DONALD CHEN-TUNG
    权利人:SCHERING PLOUGH CORP
    摘要:This invention relates to a novel process for the synthesis of Temozolomide, an antitumor compound, and analogs, and to intermediates useful in this novel process.

    专利号:US-11739359-B2
    优先权日:2020-05-01
    标 题:Universal template strands for enzymatic polynucleotide synthesis
    发明人:NGUYEN BICHLIEN; SMITH JAKE; CARLSON ROBERT; STRAUSS KARIN
    权利人:MICROSOFT TECHNOLOGY LICENSING LLC
    摘要:A universal template strand built with universal base analogs is used as a template for polynucleotide synthesis. The universal template strand can hybridize to any sequence of nucleotides. A new polynucleotide is synthesized by using a polymerase to extend a primer hybridized to the universal template strand. Unlike primer extension in polymerase chain reactions, base pairing with nucleotides in the template strand does not specify the sequence of the new polynucleotide. Instead, the sequence of the new polynucleotide is specified by the order of addition of protected nucleotides. After addition of a single species of protected nucleotide, the blocking group is removed and another protected nucleotide is added. The order of nucleotide addition can be varied to create any sequence. After synthesis, the polynucleotide can be dehybridized from the universal template strand. The universal template strand may then be reused to synthesize a different polynucleotide.

    专利号:WO-2025003669-A1
    优先权日:2023-06-27
    标题 :Polynucleotide synthesis method, kit and system
    发明人:CHAPMAN TARUN STEPHEN; CLARKE DAVID EDWARD; CLARKE JAMES ANTHONY; COOK IMOGEN HELEN; MÜLLER CAROLIN ANNE; OGAKI RYOSUKE; WHITE JAMES PHILIP
    权利人:OXFORD NANOPORE TECH PLC
    摘要:The invention relates to new methods for synthesising polynucleotide molecules according to a predefined nucleotide sequence. The invention also relates to methods for the assembly of synthetic polynucleotides following synthesis.

    专利号:US-2005131227-A1
    优先权日:2001-01-18
    标 题:Synthesis of temozolomide and analogs

    专利号:US-2006229456-A1
    优先权日:2001-01-18
    标 题:Synthesis of Temozolomide and analogs

    专利号:WO-02057269-A1
    优先权日:2001-01-18
    标题:Synthesis of temozolomide and analogs

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    合成参考文献


    参考文献:10.1021/acs.jnatprod.0c00394
    摘要:Ito A, Choi JH, Takemura H, Kotajima M, Wu J, Tokuyama S, Hirai H, Asakawa T, Ouchi H, Inai M, Kan T, Kawagishi H. Biosynthesis of the Fairy Chemicals, 2-Azahypoxanthine and Imidazole-4-carboxamide, in the Fairy Ring-Forming Fungus Lepista sordida. J Nat Prod. 2020 Aug 28;83(8):2469–76. doi: 10.1021/acs.jnatprod.0c00394.
    参考文献:10.1093/ajhp/59.14.1351
    摘要:El Aatmani M, Poujol S, Astre C, Malosse F, Pinguet F. Stability of dacarbazine in amber glass vials and polyvinyl chloride bags. Am J Health Syst Pharm. 2002 Jul 15;59(14):1351–6. doi: 10.1093/ajhp/59.14.1351.
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