📜5-(3,3-Dimethyl-1-Triazeno)Imidazone-4-Carboxamide 以 水 作为反应溶剂,化学反应生成 1,5-二氢-4H-咪唑并[4,5-D]-1,2,3-三嗪-4-酮 参考文献:A New Light On The Photo-Decomposition Of The Antitumour Drug Dtic 标题:A New Light On The Photo-Decomposition Of The Antitumour Drug Dtic 摘要: DOI:10.1111/j.2042-7158.1981.Tb13944.X
专利信息
专利号:US-7737284-B2 优先权日:2001-01-18 标题 :Synthesis of temozolomide and analogs 发明人:KUO SHEN-CHUN; MAS JANET L; HOU DONALD CHEN-TUNG 权利人:SCHERING PLOUGH CORP 摘要:This invention relates to a novel process for the synthesis of Temozolomide, an antitumor compound, and analogs, and to intermediates useful in this novel process.
专利号:US-11739359-B2 优先权日:2020-05-01 标 题:Universal template strands for enzymatic polynucleotide synthesis 发明人:NGUYEN BICHLIEN; SMITH JAKE; CARLSON ROBERT; STRAUSS KARIN 权利人:MICROSOFT TECHNOLOGY LICENSING LLC 摘要:A universal template strand built with universal base analogs is used as a template for polynucleotide synthesis. The universal template strand can hybridize to any sequence of nucleotides. A new polynucleotide is synthesized by using a polymerase to extend a primer hybridized to the universal template strand. Unlike primer extension in polymerase chain reactions, base pairing with nucleotides in the template strand does not specify the sequence of the new polynucleotide. Instead, the sequence of the new polynucleotide is specified by the order of addition of protected nucleotides. After addition of a single species of protected nucleotide, the blocking group is removed and another protected nucleotide is added. The order of nucleotide addition can be varied to create any sequence. After synthesis, the polynucleotide can be dehybridized from the universal template strand. The universal template strand may then be reused to synthesize a different polynucleotide.
专利号:WO-2025003669-A1 优先权日:2023-06-27 标题 :Polynucleotide synthesis method, kit and system 发明人:CHAPMAN TARUN STEPHEN; CLARKE DAVID EDWARD; CLARKE JAMES ANTHONY; COOK IMOGEN HELEN; MÜLLER CAROLIN ANNE; OGAKI RYOSUKE; WHITE JAMES PHILIP 权利人:OXFORD NANOPORE TECH PLC 摘要:The invention relates to new methods for synthesising polynucleotide molecules according to a predefined nucleotide sequence. The invention also relates to methods for the assembly of synthetic polynucleotides following synthesis.
专利号:US-2005131227-A1 优先权日:2001-01-18 标 题:Synthesis of temozolomide and analogs
专利号:US-2006229456-A1 优先权日:2001-01-18 标 题:Synthesis of Temozolomide and analogs
专利号:WO-02057269-A1 优先权日:2001-01-18 标题:Synthesis of temozolomide and analogs
参考文献:10.1021/acs.jnatprod.0c00394 摘要:Ito A, Choi JH, Takemura H, Kotajima M, Wu J, Tokuyama S, Hirai H, Asakawa T, Ouchi H, Inai M, Kan T, Kawagishi H. Biosynthesis of the Fairy Chemicals, 2-Azahypoxanthine and Imidazole-4-carboxamide, in the Fairy Ring-Forming Fungus Lepista sordida. J Nat Prod. 2020 Aug 28;83(8):2469–76. doi: 10.1021/acs.jnatprod.0c00394. 参考文献:10.1093/ajhp/59.14.1351 摘要:El Aatmani M, Poujol S, Astre C, Malosse F, Pinguet F. Stability of dacarbazine in amber glass vials and polyvinyl chloride bags. Am J Health Syst Pharm. 2002 Jul 15;59(14):1351–6. doi: 10.1093/ajhp/59.14.1351.