专利号:US-6723843-B2 优先权日:1996-08-26 标题:Oligosaccharide synthesis 发明人:TOTH ISTVAN; DEKANY GYULA; KELLAM BARRY 权利人:ALCHEMIA PTY LTD 摘要:The invention provides a system for solid-phase synthesis of oligosaccharides, based on the discovery that a 2-substituted-1,3-dioxocycloalkyl linker group of general formula (I) can be used to couple saccharide groups of both the O-glycoside and N-glycoside type to a polymer support. The invention provides reagents, reagent kits and methods for solid-phase oligosaccharide synthesis.
专利号:WO-0039141-A1 优先权日:1998-12-23 标 题 :Inositol-containing hexasaccharides, their synthesis and their uses 发明人:MARTIN-LOMAS MANUEL; MOSQUERA MARIA FLORES; CHIARA JOSE LUIS 权利人:RADEMACHER GROUP LIMITED; MARTIN LOMAS MANUEL; MOSQUERA MARIA FLORES; CHIARA JOSE LUIS 摘要:The application relates to the design and synthesis of novel hexasaccharides of general formula (I), wherein: each R is independently selected from hydrogen, an alkyl or substituted alkyl group, an acyl or substituted acyl group, a phosphate group (PO3- or PO¿3?H for instance) or a protecting group, or two of the R groups may be cyclic phosphate; NX group represents N3; or in the NX group, X represents one or more groups independently selected from hydrogen, alkyl or substituted alkyl, acyl or substituted acyl; NY represents a phthalimido group (NPht) or N3; or in the NY group, Y represents one or more groups independently selected from hydrogen, alkyl or substituted alkyl, acyl or substituted acyl; or a salt or derivative of said compound. Methods for synthesizing the compounds and their uses are also disclosed.
专利号:WO-9636627-A1 优先权日:1995-05-19 标 题 :Collection of activated glycoside compounds and their biological use 发明人:ANDERSON MARK BRIAN; MUSSER JOHN H 权利人:GLYCOMED INC 摘要:The present invention relates to the field of combinatorial carbohydrate chemistry and involves the modification of organic molecules and/or the synthesis of large numbers of products comprising carbohydrate and/or glycominetic entities. More specifically, the present invention relates to activated carbon glycosides useful for the modification of organic molecules by incorporation of carbohydrate units, providing the synthesis of large numbers of products having novel chemical characteristics. The present invention further relates to methods for the generation of chemical compounds comprising carbon glycosides. Methods are disclosed to provide large arrays of molecules and to identify species that act as agonists or antagonists of various biological, chemical, and other activities.
专利号:WO-9846784-A1 优先权日:1997-04-11 标 题 :Improved synthesis of oligosaccharides using activated glycoside derivatives
专利号:EP-0973932-A1 优先权日:1997-04-11 标 题 :Improved synthesis of oligosaccharides using activated glycoside derivatives
专利号:WO-2014190024-A1 优先权日:2013-05-21 标题 :Modular synthesis of amphiphilic janus glycodendrimers and their self-assembly into glycodendrimersomes