CAS: 19438-10-9; Methyl 3-Hydroxybenzoate

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CAS号67-56-1 甲醇 | CAS号99-06-9 3-羟基苯甲酸 | CAS号100-83-4 间羟基苯甲醛 | CAS号79250-46-7 methyl 3-prop-2... | CAS号585-76-2 3-溴苯甲酸 | CAS号160893-68-5 m-methoxycarbon... | CAS号96013-95-5 3-(叔丁基二甲基硅氧基)苯甲醛 | CAS号54396-74-6 3-氧代环己-1-烯甲酸甲酯 | CAS号79678-37-8 3-(苄氧基)苯甲酸甲酯 | CAS号93-58-3 苯甲酸甲酯 | CAS号108593-47-1 3-乙氧基苯甲酸甲酯 | CAS号107658-28-6 methyl 3-(trifl... | CAS号79250-46-7 methyl 3-prop-2... | CAS号412336-07-3 1-苯并呋喃-4-胺 | CAS号480425-35-2 3-甲氧羰基苯硼酸频哪醇酯 | CAS号183270-47-5 3-(3-氨基苯氧基)苯甲酸甲酯 | CAS号179637-24-2 3-[2-(2-methoxy... | CAS号24781-23-5 3-Acetoxybenzoi... | CAS号249937-00-6 3-(2-吗啉-4-基乙氧基)苯甲酸甲酯 | CAS号873-62-1 3-羟基苯腈

Methyl Shikimate置于4-二甲氨基吡啶,Camphor-10-Sulfonic Acid,Cesium Acetate体系中,用 吡啶,二氯甲烷,N,N-二甲基甲酰胺 用作溶剂,化学反应 2.67H,反应生成3-羟基苯甲酸甲酯
参考文献:Syntheses Of (6S)-6-Fluoro-And (6R)-6-Hydroxyshikimic Acids
标题:Syntheses Of (6S)-6-Fluoro-And (6R)-6-Hydroxyshikimic Acids
摘要:(6S)-6-氟黄芩酸 2 和 (6R)-6-羟基黄芩酸 3 是通过林催化二烯 6 的二羟化反应合成的,该二烯来源于 (-)-黄芩酸 1.© 2001 Elsevier Science Ltd. 保留所有权利.
Doi:10.1016/s0040-4039(01)01976-1

专利信息

专利号:US-2009131688-A1
优先权日:2007-11-21
标 题 :Method for the synthesis of 4-benzofuran-carboxylic acid
发明人：BURGOS ALAIN; MARUANI MARTINE; PERRIN FLORENCE; FREIN STEPHANE
权利人:ZACH SYSTEM
摘要:The invention concerns a novel method for synthesis of 4-benzofuran-carboxylic acid or alkyl ester thereof. n This method is characterized in that a reaction for aromatization of a compound of formula (II) is performed for the synthesis of the compound of formula (I), according to the scheme A2 below: n n n n n n n n n n wherein R independently represents hydrogen or a linear or branched C 1 - 15 alkyl group. n With the invention, it is possible to industrially synthesize 4-benzofuran-carboxylic acid or alkyl ester thereof with good yield and very good purity.

专利号:US-4760068-A
优先权日:1982-06-14
标题:Certain pyridyl alkenoic acid derivatives which inhibit the action of thromboxane A2 synthetase
发明人：TERAO SHINJI; NISHIKAWA KOHEI
权利人:TAKEDA CHEMICAL INDUSTRIES LTD
摘要:Novel compound of the formula: ##STR1## wherein R 1 is pyridyl group, R 2 is a phenyl group, a thienyl group, a furyl group, a naphthyl group, a benzothienyl group or pyridyl group, which may optionally have a lower alkoxy group, a lower alkyl group, a halogen atom, trifluoromethyl group, a lower alkenyl group or methylenedioxy group, R 3 is hydrogen atom or a lower alkyl group, and n is an integer of 0 to 6, Y is sulphur atom, methylene group or a group of the formula: ##STR2## wherein R 4 is hydrogen atom or acetyl group, and m is 0 or 1, and their pharmaceutically acceptable salts having an inhibitory action on bio-synthesis of thromboxane A 2 (TXA 2 ) and an effect of accelerating the productivility of prostaglandin I 2 (PGI 2 ), and can be used for mammals to the prophylaxis or therapy of thrombosis caused by platelet aggregation or ischemic diseases caused by vasospasms in cardiac, cerebral and peripheral circulatory system (e.g. cardiac infarction, apoplexy, infarct of blood vessels in kidney, lung and other organs, pectic ulcer, etc.).

专利号:US-2025222120-A1
优先权日:2024-01-09
标题 :Synthesis of novel small molecule carm1 degraders, compounds formed thereby, and pharmaceutical compositions containing them
发明人：TANG WEIPING; XU WEI; XIE HAIBO; BACABAC MEGAN
权利人:WISCONSIN ALUMNI RES FOUND
摘要:Provided herein are CARM1 PROTACs comprising a binding molecule of CARM1 with an optimized linker attached to an E3 ubiquitin ligase ligand that recruits the E3 ubiquitin ligase to CARM1. The PROTACs find use, e.g., for selectively targeted degradation of CARM1 protein in cancer cells. Also provided herein are compositions comprising the PROTACs, as well as methods of using the PROTACs.

专利号:US-5936132-A
优先权日:1994-03-11
标题 :Alkene intermediates and synthesis thereof
发明人：MATSUMOTO MASAKATSU
摘要:A chemiluminescent 1,2-dioxetane derivative having a formula (I): ##STR1## wherein R 1 and R 4 each represent, individually, hydrogen, an alkyl group, an alkoxyl group, a hydroxyl group, or --OS;(R 9 R 10 R 11 ) in which R 9 , R 10 and R 11 each represent an alkyl group; R 2 , R 3 , R 5 and R 6 each represent, individually, hydrogen or an alkyl group, provided that R 2 , R 3 , R 5 and R 6 each cannot be hydrogen at the same time, and that R 2 and R 3 , and R 5 and R 6 , each taken together, can form a cycloalkyl group; R 7 represents an alkyl group; R 8 represents hydrogen, an alkoxyl group, a phosphate salt group, or --OSi(R 9 R 10 R 11 ); intermediates for synthesizing the above 1,2-dioxetane derivative; and methods of producing the intermediates are provided.

专利号:US-4832879-A
优先权日:1980-03-04
标 题:Substituted 3-fluoroalkoxybenzoyl halides and their preparation
发明人：HAMPRECHT GERHARD
权利人:BASF AKTIENGESELLCHAFT
摘要:Novel substituted 3-fluoroalkoxybenzoyl halides of the formula where Hal is fluorine or chlorine, R1 is chlorodifluoromethyl, difluoromethyl, 1,1,2,2-tetrafluoroethyl, 2-bromo-1,1,2-trifluoroethyl, pentafluoroethyl or 1,1,2,3,3,3-hexafluoropropyl and R2 is hydrogen, or R1 is chlorodifluoromethyl or trifluoromethyl and R2 is chlorine, and processes for their preparation. The novel 3-fluoroalkoxybenzoyl halides are valuable intermediates for the synthesis of biologically active compounds, for example of 2-(3-fluoroalkoxyphenyl)-3,1-benzoxazin-4-ones, which are herbicidally active.

专利号:US-6069149-A
优先权日:1997-01-09
标 题:Amide derivatives and intermediates for the synthesis thereof
发明人：NANBA RYOUICHI; IIZUKA TAKAO; ISHII TAKEO
权利人:TERUMO CORP
摘要:PCT No. PCT/JP98/00005 Sec. 371 Date Nov. 23, 1998 Sec. 102(e) Date Nov. 23, 1998 PCT Filed Jan. 6, 1998 PCT Pub. No. WO98/30562 PCT Pub. Date Jul. 16, 1998Novel compounds which are amide derivatives represented by general formula (I) and medicinal preparations containing the same having an eosinophilic infiltration inhibitory effect based on a potent interferon ( alpha , gamma )-inducing activity and an exellent percutaneous absorbability and being efficacious in treating allergic inflammatory diseases such as atopic dermatitis, various tumors and viral diseases. In said formula, each symbol has the following meaning: R1 and R2: each lower alkyl, etc.; X and Y: independently representing each oxygen, NR4, CR5 etc. (wherein R4 and R5 independently represent each hydrogen, an aromatic group, etc.); Z: an aromatic ring or heterocycle; R3: hydrogen, lower alkoxy, etc.; g, i and k: independently representing each an integer of from 0 to 6; h, i and l: independently representing each an integer of 0 or 1; m: an integer of from 0 to 5; and n: an integer of from 2 to 12.