CAS: 154445-78-0; 2,2,4,6,7-Pentamethyl-2,3-Dihydrobenzofuran-5-Sulfonyl Chloride

相似化合物

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上下游产品

CAS号142874-81-5 2, 2, 4, 6, 7-五... | CAS号697-82-5 2,3,5-三甲基苯酚 | CAS号690665-11-3 2,2,4,6,7-Penta...

📜2,3,5-三甲基苯酚置于氯磺酸,硫酸体系中,用 二氯甲烷 用作溶剂,化学反应 3.0H,反应生成2,2,4,6,7-五甲基二氢苯并呋喃-5-磺酰氯
参考文献:The 2,2,4,6,7-Pentamethyldihydrobenzofuran-5-Sulfonyl Group (Pbf) As Arginine Side Chain Protectant
标题:The 2,2,4,6,7-Pentamethyldihydrobenzofuran-5-Sulfonyl Group (Pbf) As Arginine Side Chain Protectant
摘要:The 2,2,4,6,7-Pentamethyldihydrobenzofuran-5-Sulfonyl Residue (Pbf) Is More Easily Deblocked By Trifluoroacetic Acid (Tfa) Than The Corresponding Pmc Analog And Can Be Used Efficiently In The Synthesis Of Arginine-Containing Peptides.
Doi:10.1016/s0040-4039(00)61487-9

专利信息

专利号:US-10647742-B2
优先权日:2015-12-31
标题 :Method for synthesizing etelcalcetide
发明人：CHEN YONGHAN; MI PENGCHENG; TAO ANJIN; YUAN JIANCHENG
权利人:HYBIO PHARMACEUTICAL CO LTD
摘要:Provided is a method for solid phase synthesis of Etelcalcetide, comprising synthesizing Etelcalcetide backbone peptide resin, removing the side chain protecting group of Cys in the peptide chain, and then activating the sulfydryl group of the Cys side chain on the peptide resin with 2,2′-dithiodipyridine and constructing a disulfide bond with L-Cys, such that a crude Etelcalcetide peptide is obtained by cleaving. The method does not require undergoing multi-step purification, the yield and purity of the obtained crude peptide are relatively high, and the total yield of the refined peptide after purification is greatly increased.

专利号:CN-106928171-A
优先权日:2017-05-03
标 题:Synthesis of Fmoc‑Arg(Pbf)‑OH