CAS: 1530-39-8; (4-Chlorobenzyl)Triphenylphosphonium Chloride

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📜对氯苯甲酸置于lithium Aluminium Tetrahydride,氯化亚砜体系中,用 苯 用作溶剂,化学反应 4.0H,反应生成4-氯苄基三苯基氯化磷蓊盐
参考文献:Photolysis Of (Arylmethyl)Triphenylphosphonium Salts. Substituent,Counterion,And Solvent Effects On Reaction Products
标题:Photolysis Of (Arylmethyl)Triphenylphosphonium Salts. Substituent,Counterion,And Solvent Effects On Reaction Products
摘要:Quaternary (Arylmethyl)Phosphonium Salts Of The General Formula Arch2-Pr3+y-(Ar = Substituted Phenyl Or 1-Naphthyl; R = Phenyl,Ferrocenyl,Or Butyl; Y-= Bf4-Or Halide) Have Been Photolyzed In Acetonitrile Or In Methanol. Photolysis Involved The Cleavage Of The P-Ch2 Bond And The Products Derived From Both,The Arylmethyl Radical And The Carbocation,Were Formed. The Proportion Of The Radical-And Carbocation-Derived Products Was Determined As A Function Of Substituents In Group Ar,Of Groups R,Counterions Y-,And The Solvent. For The Nonoxidizable Counterion (Bf4-),The Proposed Mechanism Of The Reaction Involves Initial Homolysis,Followed By The Escape Of The Radical Products From A Solvent Cage,Or By The Electron Transfer From Carbon To Phosphorus,Yielding The Corresponding Arylmethyl Carbocation. The Latter Can Either React With The Solvent To Form The Observed Carbocation-Derived Product Or Can Undergo Recombination With The Tertiary Phosphine Formed To Yield The Starting Phosphonium Ion. Some Indication Of The ''Inverted Substituent Effect'' Resulting From The Inhibition Of Single Electron Transfer From An Easily Oxidized Radical Was Obtained. For The Oxidizable Counterions (Halides),An Additional Pathway Is Suggested,That Involves Electron Transfer From The Anion,Yielding The Arylmethyl Radical And The Phosphine,Thus Decreasing The Ionic/radical Products Ratio.
Doi:10.1021/jo00073A023

专利信息

专利号:US-4564476-A
优先权日:1984-10-29
标 题 :Aryl fatty acid leukotriene synthesis inhibitors
发明人：HO CHIH Y
权利人:MCNEILAB INC
摘要:Aryl fatty acid compounds of the formula (I) ##STR1## wherein R 1 , R 2 , R 3 , X, and Y are as defined herein are novel and useful in the treatment of allergic and inflammatory disorders.

专利号:US-6936600-B2
优先权日:1999-04-01
标题:Sorbitol dehrydrogenase inhibitors
发明人：CHU-MOYER MARGARET Y; MYLARI BANAVARA L; ZEMBROWSKI WILLIAM J
权利人:PFIZER
摘要:This invention is directed to sorbitol dehydrogenase inhibitory compounds of the formula I, n n nwherein R 1 , R 2 and R 3 are as defined in the specification. This invention is also directed to pharmaceutical compositions containing those compounds and methods of treating or preventing diabetic complications, particularly diabetic neuropathy, diabetic nephropathy, diabetic microangiopathy, diabetic macroangiopathy and diabetic cardiomyopathy by administering such compounds to a mammal suffering from diabetes and therefore at risk for developing such complications. This invention is also directed to pharmaceutical compositions comprising a combination of a compound of formula I of this invention with an aldose reductase inhibitor and to methods of treating or preventing diabetic complications therewith. This invention is also directed to pharmaceutical compositions comprising a combination of a compound of formula I of this invention with an NHE-1 inhibitor and to methods of treating cardiomyopathy and other heart-related problems therewith. This invention is also directed to certain intermediates used in the synthesis of the compounds of formula I and to processes for preparing those intermediates.