CAS: 143120-46-1; (2S,31R,7Ar,8R,8Ar,11S,11Ar,11Bs)-8-Ethyl-11-Methyl-2-((2S,4S)-4-Methyl-5-Oxotetrahydrofuran-2-yl)Dodecahydroazepino[3,2,1-Hi]Furo[3,2-E]Indol-10(2H)-One
该化合物是属于藻类类的化学化合物,这种化合物是自然产生的有机化合物,主要含有基本氮原子,该物质来自某些植物物种,以其潜在的生物活动,包括防炎和止痛特性而著称.新紫外线素展示了一个复杂的分子结构,有助于其药理效应.通常研究该物质与各种生物目标的相互作用,使其对医药化学和药物开发感兴趣.该化合物的溶解性,稳定性和再活性可因环境条件和其他物质的存在而变化.许多藻类,安全和毒性特征是应用中的重要考虑因素,需要深入研究,以了解其对人体健康和环境的影响.
- 英文名称(2S,31R,7Ar,8R,8Ar,11S,11Ar,11Bs)-8-Ethyl-11-Methyl-2-((2S,4S)-4-Methyl-5-Oxotetrahydrofuran-2-yl)Dodecahydroazepino[3,2,1-Hi]Furo[3,2-E]Indol-10(2H)-One
- 中文名称新对叶百部碱
- IUPAC名称(2S,31R,7aR,8R,8aR,11S,11aR,11bS)-8-ethyl-11-methyl-2-((2S,4S)-4-methyl-5-oxotetrahydrofuran-2-yl)dodecahydroazepino[3,2,1-hi]furo[3,2-e]indol-10(2H)-one
- 其它别名Neotuberostemonine; Furo[2,3-H]Pyrrolo[3,2,1-Jk][1]Benzazepin-10(2H)-One,8-Ethyldodecahydro-11-Methyl-2-[(2S,4S)-Tetrahydro-4-Methyl-5-Oxo-2-Furanyl]-,(2S,7Ar,8R,8Ar,11S,11Ar,11Bs,11Cr)-; (2S,7Ar,8R,8Ar,11S,11Ar,11Bs,11Cr)-8-Ethyl-11-Methyl-2-[(2S,4S)-4 -Methyl-5-Oxotetrahydro-2-Furanyl]Dodecahydroazepino[3,2,1-Hi]Fur O[3,2-E]Indol-10(2H)-One; (2S,31R,7Ar,8R,8Ar,11S,11Ar,11Bs)-8-Ethyl-11-Methyl-2-((2S,4S)-4-Methyl-5-Oxotetrahydrofuran-2-yl)Dodecahydroazepino[3,2,1-Hi]Furo[3,2-E]Indol-10(2H)-One; Neotuberostemonine, 10 Mm In Dmso
- CAS编号143120-46-1
- MFCD编号:MFCD17214798
- 分子式:C22H33NO4分子量:375.51
- 产品CID: 658858
- 产品分类天然产物 → 生物碱
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主要参考文献
1: Xiang J, Cheng S, Feng T, Wu Y, Xie W, Zhang M, Xu X, Zhang C. Neotuberostemonine attenuates bleomycin-induced pulmonary fibrosis by suppressing the recruitment and activation of macrophages. Int Immunopharmacol. 2016Jul;36:158-164. doi: 10.1016/j.intimp.2016.04.016. Epub 2016 May 1. doi: 10.1016/j.biochi.2018.11.008. Epub 2018 Nov 13. doi: 10.1016/j.biochi.2018.11.008. Epub 2018 Nov 13.
合成参考文献
参考文献:10.1016/s0031-9422(00)89558-8
摘要:Yang YE, Guo-Wei Q, Ren-Sheng X. Alkaloids from Stemona tuberosa. Phytochemistry. 1994 Nov;37(4):1201–3. doi: 10.1016/s0031-9422(00)89558-8.
参考文献:10.1021/np2004374
摘要:Kongkiatpaiboon S, Schinnerl J, Felsinger S, Keeratinijakal V, Vajrodaya S, Gritsanapan W, Brecker L, Greger H. Structural relationships of stemona alkaloids: assessment of species-specific accumulation trends for exploiting their biological activities. J Nat Prod. 2011 Sep 23;74(9):1931–8. doi: 10.1021/np2004374.
参考文献:10.1016/j.jpba.2017.04.018
摘要:Tong Y, Xu W, Wu Y, Ou L, Zhang M, Xu X, Zhang C. Metabolic profiles of neotuberostemonine and tuberostemonine in rats by high performance liquid chromatography/quadrupole time-of-flight mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis. 2017 Jul;141():210–21. doi: 10.1016/j.jpba.2017.04.018.
参考文献:10.1016/j.fitote.2016.05.003
摘要:Wu Y, Ou L, Han D, Tong Y, Zhang M, Xu X, Zhang C. Pharmacokinetics, biodistribution and excretion studies of neotuberostemonine, a major bioactive alkaloid of Stemona tuberosa. Fitoterapia. 2016 Jul;112():22–9. doi: 10.1016/j.fitote.2016.05.003.
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