CAS: 13862-28-7; Potassium Trifluoro(Methyl)Borate

相似化合物

13061-96-6 1332481-37-4 882871-21-8

三甲基环三硼氧烷置于potassium Hydrogen Bifluoride,水体系中,用 乙腈 用作溶剂,化学反应 3.0H,以80%的收率获得甲基三氟硼酸钾
参考文献:空气稳定的烷基三氟硼酸钾的b-烷基铃木-宫浦交叉偶联反应.
标题:空气稳定的烷基三氟硼酸钾的b-烷基铃木-宫浦交叉偶联反应.
摘要:取代的烷基三氟硼酸钾与芳基卤化物和芳基三氟甲磺酸酯的钯催化交叉偶联反应易于进行,产率中等至非常好.烷基三氟硼酸钾1,2和3A-E易于合成,并以空气稳定的结晶固体形式获得,可以长期保存.所有交叉偶联均在相同的反应条件下使用pdcl(2)(dppf).Ch(2)cl(2)作为催化剂在thf-H(2)o中在3当量的cs(2)存在下进行以co(3)为基.
Doi:10.1021/jo0343331

专利信息

专利号:US-9168248-B2
优先权日:2009-02-17
标 题:Spiro compounds useful as inhibitors of stearoyl-coenzyme A delta-9 desaturase
发明人：LACHANCE NICOLAS; LECLERC JEAN-PHILIPPE; LI CHUN SING; MORADEI OSCAR MIGUEL
权利人:LACHANCE NICOLAS; LECLERC JEAN-PHILIPPE; LI CHUN SING; MORADEI OSCAR MIGUEL; MERCK CANADA INC
摘要:Heteroaromatic compounds of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.

专利号:US-9637498-B2
优先权日:2013-08-23
标 题:Substituted thieno[2,3-C]pyridazine-6-carboxamide analogs as positive allosteric modulators of the muscarinic acetylcholine receptor M4
发明人：LINDSLEY CRAIG W; CONN P JEFFREY; WOOD MICHAEL R; POSLUSNEY MICHAEL S; TARR JAMES C; MELANCON BRUCE J
权利人:UNIV VANDERBILT
摘要:In one aspect, the invention relates to substituted 5-aminothieno[2,3-c]pyridazine-6-carboxamide analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

专利号:US-8383643-B2
优先权日:2009-07-28
标题 :Spiro compounds useful as inhibitors of stearoyl-coenzyme A delta-9 desaturase
发明人：LECLERC JEAN-PHILIPPE; LI CHUN-SING; MORADEI OSCAR MIGUEL
权利人:MERCK CANADA INC; LECLERC JEAN-PHILIPPE; LI CHUN-SING; MORADEI OSCAR MIGUEL
摘要:Heteroaromatic compounds of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.

专利号:CN-114574882-A
优先权日:2022-03-28
标题 :Method for the synthesis of ortho-position alkylarylpyridines by electrochemical oxidative dehydrogenation coupling

专利号:US-9879022-B2
优先权日:2014-04-04
标题:Bicyclic-fused heteroaryl or aryl compounds
发明人：TRZUPEK JOHN DAVID; LEE KATHERINE LIN; BUNNAGE MARK EDWARD; HAN SEUNGIL; HEPWORTH DAVID; LOVERING FRANK ELDRIDGE; MATHIAS JOHN PAUL; PAPAIOANNOU NIKOLAOS; PIERCE BETSY SUSAN; STROHBACH JOSEPH WALTER; WRIGHT STEPHEN WAYNE; ZAPF CHRISTOPH WOLFGANG; GAVRIN LORI KRIM; LEE ARTHUR; ANDERSON DAVID RANDOLPH; CURRAN KEVIN JOSEPH; DEHNHARDT CHRISTOPH MARTIN; SAIAH EDDINE; GOLDBERG JOEL ADAM; WANG XIAOLUN; HUANG HORNG-CHIH; VARGAS RICHARD; LOWE MICHAEL DENNIS; PATNY AKSHAY
权利人:PFIZER
摘要:Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula Ia, n nas defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:CN-117343044-A
优先权日:2023-09-15
标题:Synthesis method of 2-methyl-1- (pyridine-2-yl) indole compound