CAS: 1373423-53-0; Ethyl 3-((6-(4,5-Dihydro-1H-Benzo[d]Azepin-3(2H)-yl)-2-(Pyridin-2-yl)Pyrimidin-4-yl)Amino)Propanoate

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物理性质

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C&L通报

上下游产品

2-(pyridin-2-yl)-4,6-dichloropyrimidine ethyl β-alaninate hydr°Chloride 2,3,4,5-tetrahydro-1H-3-benzazepine ethyl N-[6-chloro-2-(2-pyridinyl)-4-pyrimidinyl]-β-alaninateGSK-J1

合成工艺路线路线简述

  • 合成目标产物 Gsk J4 Hcl 主要起始原料 2,3,4,5-Tetrahydro-1H-Benzo[d]Azepine And Ethyl 3-((6-Chloro-2-(Pyridin-2-yl)Pyrimidin-4-yl)Amino)Propanoate
  • (文献来源)合成步骤主要原料 2,3,4,5-Tetrahydro-1H-Benzo[d]Azepine 和 Ethyl 3-((6-Chloro-2-(Pyridin-2-yl)Pyrimidin-4-yl)Amino)Propanoate

海关参考信息

专利信息


专利号:US-8729270-B2
优先权日:2008-03-03
标 题:Anti-cancer compounds, synthesis thereof, and methods of using same
发明人：MILLER MARVIN J; MORASKI GARRETT C; STEFELY JONATHAN
权利人:MILLER MARVIN J; MORASKI GARRETT C; STEFELY JONATHAN; UNIV NOTRE DAME DU LAC
摘要:Embodiments relate to the field of chemistry and biochemistry, and, more specifically, to anti-cancer compounds, synthesis thereof, and methods of using same. Disclosed herein are various heterocyclic compounds and methods of using the novel anti-cancer compounds to inhibit the growth of a cancer cell, for instance a leukemia, non-small cell lung, central nervous system (CNS), skin, ovarian, renal, prostate, breast, or colon cancer cell. Other embodiments include methods of treating cancer in a subject, such as using the disclosed heterocyclic anti-cancer agents.

专利号:CN-113200971-A
优先权日:2021-05-14
标 题 :Synthesis and application of a class of indoleoxadiazole derivatives with aromatic piperazine structure

专利号:US-8268874-B2
优先权日:2008-03-03
标 题:Anti-cancer compounds, synthesis thereof, and methods of using same

专利号:US-2011021574-A1
优先权日:2008-03-03
标 题 :Anti-cancer compounds, synthesis thereof, and methods of using same

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主要参考文献


1: Wu W, Qin M, Jia W, Huang Z, Li Z, Yang D, Huang M, Xiao C, Long F, Mao J, Moore PK, Liu X, Zhu YZ. Cystathionine-γ-lyase ameliorates the histone demethylase JMJD3-mediated autoimmune response in rheumatoid arthritis. Cell Mol Immunol. 2018 May 29. doi: 10.1038/s41423-018-0037-8. [Epub ahead of print] doi: 10.18632/oncotarget.25182. eCollection 2018 May 4.
3: Lochmann TL, Powell KM, Ham J, Floros KV, Heisey DAR, Kurupi RIJ, Calbert ML, Ghotra MS, Greninger P, Dozmorov M, Gowda M, Souers AJ, Reynolds CP, Benes CH, Faber AC. Targeted inhibition of histone H3K27 demethylation is effective in high-risk neuroblastoma. Sci Transl Med. 2018 May 16;10(441). pii: eaao4680. doi: 10.1126/scitranslmed.aao4680. doi: 10.1016/j.intimp.2018.03.027. Epub 2018 Apr 3. doi: 10.1007/s00432-018-2631-7. Epub 2018 Mar 28.
7: Jia W, Wu W, Yang D, Xiao C, Su Z, Huang Z, Li Z, Qin M, Huang M, Liu S, Long F, Mao J, Liu X, Zhu YZ. Histone demethylase JMJD3 regulates fibroblast-like synoviocyte-mediated proliferation and joint destruction in rheumatoid arthritis. FASEB J. 2018 Jul;32(7):4031-4042. doi: 10.1096/fj.201701483R. Epub 2018 Feb 26. doi: 10.14348/molcells.2018.2311. Epub 2018 Feb 23.

合成参考文献


参考文献:10.1002/iub.2110
摘要:Lhuissier E, Aury-Landas J, Allas L, Boittin M, Boumediene K, Baugé C. Antiproliferative effect of the histone demethylase inhibitor GSK-J4 in chondrosarcomas. IUBMB Life. 2019 Nov;71(11):1711–9. doi: 10.1002/iub.2110.
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