CAS: 1155-62-0; Z-Glu-Oh

相似化合物

63648-73-7 121343-82-6 138-15-8

上下游产品

CAS号56-86-0 L-谷氨酸 | CAS号501-53-1 氯甲酸苄酯 | CAS号15231-21-7 N-Cbz-β-cyanome... | CAS号1155-62-0 N-苄氧羰基-L-谷氨酸 | CAS号82911-69-1 9-芴甲基-N-琥珀酰亚胺碳酸酯 | CAS号419533-86-1 benzyl 4,6-dime... | CAS号32159-21-0 CBZ-L-焦谷氨酸 | CAS号38101-59-6 奥谷法奈 | CAS号35989-16-3 甲基谷氨酸 | CAS号4652-65-7 N-苄氧羰基-L-谷氨酸- 5-甲酯 | CAS号5672-83-3 |N|-苄氧羰基-L-谷氨酸甲酯 | CAS号3705-42-8 Cbz-L-谷氨酸 1-苄酯 | CAS号19525-56-5 3-(2-oxo-3-phen... | CAS号56-86-0 L-谷氨酸 | CAS号6893-26-1 D-谷氨酸 | CAS号147-85-3 脯氨酸

Z-L-Gluome置于水体系中,用 异丙醇 用作溶剂,化学反应 48.0H,以11%的收率获得n-苄氧羰基-L-谷氨酸
参考文献:Cerovsky,Vaclav; Martinek,Karel,Collection Of Czechoslovak Chemical Communications,1989,Vol. 54,# 7,P. 2027-2041
标题:Cerovsky,Vaclav; Martinek,Karel,Collection Of Czechoslovak Chemical Communications,1989,Vol. 54,# 7,P. 2027-2041

专利信息

专利号:WO-2010103857-A1
优先权日:2009-03-12
标 题 :Method for solid-phase synthesis of glycopeptide using silicon-containing protecting group and synthesis device
发明人：NISHIMURA SHIN-ICHIRO; SHIMAWAKI KEN
权利人:UNIV HOKKAIDO NAT UNIV CORP; NISHIMURA SHIN-ICHIRO; SHIMAWAKI KEN
摘要:Disclosed are a novel method for the synthesis of a glycopeptide by which glycopeptides of various types can be deprotected and excised from a resin, each under weakly acidic to weakly basic conditions, without causing the problems of the epimerization of an amino acid at the a-position and the ß-elimination of a sugar residue; a synthesis device therefor; and a synthesis intermediate to be used in synthesizing a glycopeptide. Specifically disclosed are a method for the solid-phase synthesis of a glycopeptide which comprises a step for obtaining a glycopeptide derivative wherein the N-terminus is protected, the C-terminus is immobilized to a solid phase via a silicon linker, and a reactive group carried by a sugar residue and a reactive group carried by an amino acid side chain constituting a peptide are protected by silicon-containing groups, and a step for obtaining the glycopeptide by deprotecting said glycopeptide derivative and releasing the same from the solid phase by treating the glycopeptide derivative with an agent for removing the silicon-containing groups and the silicon linker; a synthesis intermediate to be used in the step for obtaining the glycopeptide derivative in the aforesaid method; and a device for the solid-phase synthesis of a glycopeptide.

专利号:US-4504415-A
优先权日:1983-04-04
标题:Synthesis of thymosin α1 and desacetyl thymosin α1
发明人：FELIX ARTHUR M; GILLESSEN DIETER; STUDER ROLF; MEIENHOFER JOHANNES A; TRZECIAK ARNOLD
权利人:HOFFMANN LA ROCHE
摘要:An improved solution phase synthesis of thymosin alpha 1 and desacetyl thymosin alpha 1 with t-Boc side chain protection and proceeding through novel intermediates is disclosed.

专利号:US-4517119-A
优先权日:1983-04-04
标题:Synthesis of thymosin α1
发明人：FELIX ARTHUR M; GILLESSEN DIETER; LERGIER WILLIAM; MEIENHOFER JOHANNES A; TRZECIAK ARNOLD
权利人:HOFFMANN LA ROCHE
摘要:An improved solution phase synthesis of thymosin α 1 and proceeding through novel intermediates is disclosed.

专利号:US-9458188-B2
优先权日:2010-12-22
标 题 :Efficient peptide couplings and their use in the synthesis and isolation of a cyclopenta (G) quinazoline trisodium salt
发明人：KERSCHEN JAMES ALAN; BRIDGES ALEXANDER JAMES; CHOUBAL MILIND D; DALZIEL SEAN MARK; JACKS THOMAS ELLIOTT; THOMPSON ANDREW S; ZELLER JAMES ROBERT
权利人:KERSCHEN JAMES ALAN; BRIDGES ALEXANDER JAMES; CHOUBAL MILIND D; DALZIEL SEAN MARK; JACKS THOMAS ELLIOTT; THOMPSON ANDREW S; ZELLER JAMES ROBERT; BTG INT LTD
摘要:A new method for the synthesis of L-Glutamyl-γ-D-Glutamic acid and its use in the synthesis of (2R)-((4S)-carboxy-4-(4,N-(((6S)-2-(hydroxymethyl)-4-oxo-3,4,7,8-tetrahydro-3H-cyclopenta[g]quinazolin-6-yl)-N-(prop-2-ynyl)amino)benzamido)butanamido)pentanedioic acid, 1 are provided. Also provided is an efficient method for the isolation and purification of the trisodium salt of the abovementioned acid, 2, in a form suitable for long term storage and use in a parenteral dosing form.

专利号:US-9284266-B2
优先权日:2012-01-19
标题:Method for synthesizing ramalin and ramalin precursor by using glutamic acid derivative and hydroxy aniline or hydroxy aniline having protected hydroxy group
发明人：YIM JOUNG HAN; KIM IL CHAN; KIM DOCKYU; HAN SE JONG; LEE HYOUNG SEOK; BHATTARAI HARI DATTA; KIM TAI KYOUNG; KIM KEUN SIK
权利人:YIM JOUNG HAN; KIM IL CHAN; KIM DOCKYU; HAN SE JONG; LEE HYOUNG SEOK; BHATTARAI HARI DATTA; KIM TAI KYOUNG; KIM KEUN SIK; KOREA INST OF OCEAN SCIENCE AND TECHNOLOGY
摘要:Disclosed is a method of the synthesis of ramalin. It comprises reacting a glutamic acid derivative, which is prepared using alkylchloroformate, with a hydrazine salt compound, which is prepared from hydroxy aniline, whether protected or not. The synthesis method allows ramalin, excellent in antioxidant and anti-inflammatory activity, to be simply synthesized at stable yield even without use of a highly toxic solvent such as DMF. In addition, the method is cost competitive, and provides ramalin at high efficiency, thus enabling the mass production of ramalin.

专利号:US-6737541-B2
优先权日:2000-01-26
标题 :Preparation of nitrogen mustard derivatives
发明人：SIEDLECKI PAUL STANISLAW; GLANVILLE MARTIN DAVID MICHAEL
权利人:ASTRAZENECA AB
摘要:This invention relates to an improved synthesis of 5-(N-[(S)-N-{N,N-bis( 2-chloroethyl)amino}phenoxycarbonyl)-gamma-glutamyl]amino)isophthalic acid (also named ZD9063P), a prodrug used in Antibody Directed Enzyme Prodrug Therapy (ADEPT), a targeted cytotoxic cancer therapy. Another aspect of the invention comprises a compound of Formula (I) in which R<1 >and R<2 >are chloro, R<3 >is an alphamethylbenzylamine salt of carboxylic acid, (R<4>)n represents a benzyl protected 3,5-dicarboxylic acid and the asterisked chiral carbon in Formula (I) has S configuration, preferably in crystalline form.