CAS: 108-01-0; 2-(Dimethylamino)Ethanol

该化合物是一种有机化合物,其特征为矿物质和酒精功能组;它看起来无色无色,可粉黄,具有典型的矿物质气味;该化合物溶于水和有机溶剂,具有多种用途;它具有相对较低的沸点和中等密度;二甲基氨基乙醇的存在具有基本特性,使其在化学反应中可以作为薄弱基点和核素. 2-(二甲基氨基)乙醇通常用作溶剂,合成药物中的化学中间体以及各种工业应用中的表面活性剂.此外,它可以参与诸如通灵敏和细胞化等反应,有助于其在有机合成中的用途.然而,由于它可能对皮肤和呼吸系统产生刺激作用,因此应该谨慎地处理它.在实验室或工业环境中与该化合物打交道时,应该注意适当的安全措施.

结构式图片

欧盟法规

统一分类与标签压力设备指令-第1组危险流体REACH注册ECHA物质欧盟气雾剂指令-标签制度工作场所安全标识要求ECHA物质C&L通报REACH预注册废弃物危险特性清单

上下游产品

oxirane dimethyl amine choline N-methoxycarbonyl-N-methyl-glycineN-methoxycarbonyl-N-methyl-glycine1-O-Dimethylaminoethyl-ethylenglykol (2-hydroxyethyl)(methyl)amine formaldehyd DMAE succinate

合成工艺路线路线简述

    三乙醇胺置于palladium/alumina 氢气体系中,化学反应 30.0H,反应生成N,N-二甲基乙醇胺
    参考文献:Synthesis Of 2-(Dimethylamino)Ethanol By The Hydrogenolysis Of Tris(2-Hydroxyethyl)Amine
    标题:Synthesis Of 2-(Dimethylamino)Ethanol By The Hydrogenolysis Of Tris(2-Hydroxyethyl)Amine
    摘要:本发明公开了一种在金属钯催化剂上利用分子氢将三(2-羟乙基)胺选择性氢解为 2-(二甲基氨基)乙醇的新反应.
    Doi:10.1039/cc9960001829

    专利信息


    专利号:US-8067633-B2
    优先权日:2006-12-05
    标 题:Method for the synthesis of (meth)acrylic esters catalysed by a polyol titanate
    发明人:PAUL JEAN-MICHEL
    权利人:PAUL JEAN-MICHEL; ARKEMA FRANCE
    摘要:The subject of the invention is a method for the synthesis of (meth)acrylic esters by transesterification in the presence of a catalyst corresponding to the formula [(R′O) 3 Ti] x R″ in which R′ is a linear or branched alkyl radical having from 2 to 8 carbon atoms which may contain heteroatoms or R′ is a phenyl radical, R′ is a polyfunctional radical, originating from a polyol R′(OH) x comprising x alcohol functional groups and x is an integer ranging from 2 to 6. The method according to the invention is particularly well suited to the synthesis of dialkylaminoalkyl (meth)acrylates from methyl (meth)acrylate and a dialkylaminoalcohol.

    专利号:US-9126196-B2
    优先权日:2009-05-26
    标题 :Composition including dialkyl tin oxide and use thereof as a transesterification catalyst for the synthesis of (meth) acrylic esters
    发明人:PAUL JEAN-MICHEL; TONNELIER BORIS; AUGUSTIN FRANCIS
    权利人:PAUL JEAN-MICHEL; TONNELIER BORIS; AUGUSTIN FRANCIS; ARKEMA FRANCE
    摘要:The present invention relates to a composition including a dialkyl tin oxide, such as DBTO, which can be used as a transesterification catalyst for the synthesis of (meth)acrylic esters. The invention also relates to a method for the synthesis of (meth)acrylic esters by transesterification in the presence of said composition.

    专利号:US-6620983-B1
    优先权日:2002-06-12
    标 题 :Synthesis of aluminophosphates and silicoaluminophosphates
    发明人:CAO GUANG; SHAH MATU J; STROHMAIER KARL G; HALL RICHARD B
    权利人:EXXONMOBIL CHEM PATENTS INC
    摘要:The invention is directed to a method of synthesizing aluminophosphate or silicoaluminophosphate molecular sieves and in particular to the synthesis of silicoaluminophosphate molecular sieves using synthesis templates in combination with a source of fluoride comprising at least two fluoride substituents. The use of such fluorine containing compounds results in good quality low silica SAPO molecular sieves of CHA framework type.

    专利号:US-2008125587-A1
    优先权日:2006-05-25
    标 题 :Synthesis of triazole compounds that modulate HSP90 activity
    发明人:CHIMMANAMADA DINESH U; LEE CHI-WAN; JAMES DAVID; ZHANG SHIJIE; YING WEIWEN; CHAE JUNGHYUN; PRZEWLOKA TERESA
    权利人:CHIMMANAMADA DINESH U; LEE CHI-WAN; JAMES DAVID; ZHANG SHIJIE; YING WEIWEN; CHAE JUNGHYUN; PRZEWLOKA TERESA
    摘要:The present invention provides novel methods of preparing triazole compounds which inhibit the activity of Hsp90. One embodiment of the invention is directed to methods for preparing a triazole compound represented by the following Structural Formula: n n n n n n n n n n or a tautomer, a pharmaceutically acceptable salt, solvate, or clathrate, or a prodrug thereof, comprising the steps of: a) reacting an amide represented by the following Structural Formula: n n n n n n n n n n with a thionation reagent to form a thioamide; b) reacting the thioamide of step a) with hydrazine to form a hydrazonamide; c) reacting the hydrazonamide of step b) with a carbonylation or a thiocarbonylation reagent. n In one embodiment, the present invention is a method of synthesis of a compound of formula (IA) n n n n n n n n n n or a tautomer, a pharmaceutically acceptable salt, solvate, or clathrate, or a prodrug thereof, comprising reacting a compound of formula (IIA) n n n n n n n n n n with an oxidizing agent, thereby producing a compound of formula (IA). n The present invention is also directed to a method of preparing a compound or a tautomer thereof represented by the following Structural Formula: n n n n n n n n n n or a tautomer, a pharmaceutically acceptable salt, solvate, or clathrate, or a prodrug thereof. The method comprises the step of reacting a first starting compound represented by the following Structural Formula: n n n n n n n n n n in the presence of a mercuric salt, with a second starting compound represented by the following Structural Formula:

    专利号:EP-2173892-B8
    优先权日:2007-07-27
    标题:Process for the preparation of immobilised recombinant Penicillin Acylase biocatalyst from Achromobacter sp CCM 4824 expressed in E. coli BL21 CCM 7394 and its use for the synthesis of beta-lactam antiobiotics
    发明人:DATLA ANUPAMA; RAJASEKAR VYASARAYANI WILLIAMS; KYSLIK PAVEL; BECKA STANISLAV; KRISHNAKANT ASHAR TRUPTI; YOGESH ZAMBRE SUJATA; NIKUNJ KUMAR
    权利人:FERMENTA BIOTECH LTD
    摘要:The present invention discloses isolation of Penicillin Acylase (PA) from Achromobacter sp CCM 4824 expressed in recombinant strain E. coli BL21 CCM 7394 bearing the recombinant plasmid pKXIP1 and processing of PA into biocatalyst useful for the industrial synthesis of antibiotics. More particularly the invention discloses a synthesis of semi-synthetic β-lactam antibiotics in the reaction mixture consisting of activated acyl-donor (D-p-hydroxyphenylglycine methyl ester or amide for Amoxicillin and Cefadroxil; D-phenylglycine methyl ester or amide for Ampicillin and Cephalexin) and nucleophile (6-APA or 7-ADCA) catalyzed by PA obtained from recombinant E. coli BL21 CCM 7394 as the biocatalyst.

    专利号:US-6127489-A
    优先权日:1996-05-20
    标题:Silyl linker for solid phase organic synthesis of aryl-containing molecules
    发明人:NEWLANDER KENNETH A; MOORE MICHAEL L
    权利人:SMITHKLINE BEECHAM CORP
    摘要:This invention relates to improved silyl linkers, methods for their preparation and their use in the solid phase synthesis of aromatic carbocycles, especially electron deficient aromatic carbocycles.
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    主要参考文献


    1: Tammenmaa-Aho I, Asher R, Soares-Weiser K, Bergman H. Cholinergic medication for antipsychotic-induced tardive dyskinesia. Cochrane Database Syst Rev. 2018 Mar 19;3:CD000207. doi: 10.1002/14651858.CD000207.pub2. Review. Available from http://www.ncbi.nlm.nih.gov/books/NBK1141/ doi: 10.17116/jnevro20171179131-36. Russian. Epub 2014 Sep 3. doi: 10.17116/jnevro20161163231-36. Russian. doi: 10.1007/s00216-015-8470-3. Epub 2015 Jan 30. doi: 10.1007/s11030-014-9559-x. Epub 2014 Dec 21. doi: 10.1155/2014/507351. Epub 2014 Jul 14.
    10: L'Haridon S, Chalopin M, Colombo D, Toffin L. Methanococcoides vulcani sp. nov., a marine methylotrophic methanogen that uses betaine, choline and N,N-dimethylethanolamine for methanogenesis, isolated from a mud volcano, and emended description of the genus Methanococcoides. Int J Syst Evol Microbiol. 2014 Jun;64(Pt 6):1978-83. doi: 10.1099/ijs.0.058289-0. Epub 2014 Mar 10. Russian. doi: 10.1016/j.jchromb.2013.10.039. Epub 2013 Nov 2. doi: 10.1016/j.apradiso.2013.04.017. Epub 2013 Apr 24.
    14: Watkins AJ, Roussel EG, Webster G, Parkes RJ, Sass H. Choline and N,N-dimethylethanolamine as direct substrates for methanogens. Appl Environ Microbiol. 2012 Dec;78(23):8298-303. doi: 10.1128/AEM.01941-12. Epub 2012 Sep 21.

    合成参考文献


    参考文献:10.1007/s11920-011-0217-z
    摘要:Hurt EA, Arnold LE, Lofthouse N. Dietary and nutritional treatments for attention-deficit/hyperactivity disorder: current research support and recommendations for practitioners. Curr Psychiatry Rep. 2011 Oct;13(5):323–32. doi: 10.1007/s11920-011-0217-z.
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