CAS: 1070-64-0; Ethyl 6,8-Dichlorooctanoate

相似化合物

1071-71-2 929-16-8 41443-60-1

上下游产品

CAS号1070-65-1 6-羟基-8-氯辛酸乙酯 | CAS号626-86-8 己二酸单乙酯 | CAS号41443-60-1 6,8-二氯辛酸乙酯 | CAS号6708-13-0 5-(diselenolan-... | CAS号46353-61-1 ethyl 5-(dithio...

7-羟基庚酸乙酯置于氯化亚砜,Alumina,Pd/γ-Al2O3,氢气体系中,用 水 用作溶剂,80.0~350.0 °C,5.0 Mpa 条件下,反应 14.0H,反应生成6,8-二氯辛酸乙酯
参考文献:一种制备6,8-二氯辛酸乙酯的方法
标题:一种制备6,8-二氯辛酸乙酯的方法
摘要:本发明提供一种制备6,8‑二氯辛酸乙酯的方法.如以下反应式所示,所述方法包括如下反应:化合物1经过氧化酯化得到化合物2,后经过脱水生成化合物3,再经过prins缩合反应得到化合物4,然后经过水解加氢得到化合物5,最后经过氯化得到6,8‑二氯辛酸乙酯.所述方法具有原料易得,工艺简单,效率高,绿色环保的特点.

专利信息

专利号:US-6844450-B2
优先权日:2000-10-10
标 题 :Process for the production of a racemic thioctic acid
发明人：SALVI ANNIBALE; MAIORANA STEFANO; CORCELLA FRANCESCO
权利人:LABORATORIO CHIMICO INT SPA
摘要:Process for the synthesis of racemic thioctic acid comprising the following stages: a) reaction of the alkyl ester of 6,8-di-halo-octanoic acid in an organic solvent with an aqueous solution of alkali disulfide in presence of a compound for phase transfer catalysis selected from the group consisting of quaternary ammonium or phosphonium salts having the following general formula: where: A is nitrogen of phosphorus, X is selected from the group consisting of Cl, Br, I, HSO 4 , and H 2 PO 4 and the substitutents R 1 , R 2 , R 3 and R 4 are selection from the group consisting of linear or branched alkyl radicals having one to twenty carbon atoms (C1-C20), said substituents being identical or different one from the other, or only one of said substituents is selected from the group consisting of arylalkyl radicals having the following formula —(CH 2 ) n C 6 H 5 in which n=1-16; b) followed by the hydrolysis of the ester of racemic thiotic acid.

专利号:US-3223712-A
优先权日:1960-07-18
标 题 :Synthesis of thioctic acid and thioctic acid amide
发明人：HIDEO OSE; KENICHI YOSHIDA
权利人:YAMANOUCHI PHARMA CO LTD

专利号:CN-117510332-A
优先权日:2022-07-27
标题:A new method for the synthesis of 6,8-dichlorooctanoate

专利号:CN-116283570-A
优先权日:2023-03-27
标 题 :One-pot Synthesis of 6,8-Dichlorooctanoate