CAS: 10406-89-0; 5-((3As,4S,5S,6Ar)-5-Oxido-2-Oxohexahydro-1H-Thieno[3,4-D]Imidazol-4-yl)Pentanoic Acid

上下游产品

D-生物素 Biotin 58-85-5

📜,D-生物素,,溶剂黄146置于crude Product,Silica Gel,Dichloromethane Methanol Water,甲醇体系中,化学反应 1.33H,以so As To Obtain 51.6 Mg Of The Title Compound (Yield: 97%的收率获得d-生物素
参考文献:Modified Biotin,Mutant Streptavidin,And Use Thereof
标题:Modified Biotin,Mutant Streptavidin,And Use Thereof
摘要:本发明的目的是提供一种突变链霉亲和素,其对天然生物素的亲和力降低,并提供一种修饰的生物素,其对该突变链霉亲和素具有高亲和力,同时降低对天然生物素的亲和力.根据本发明,提供了一种用于治疗或诊断的试剂盒,包括:(a)一种对天然生物素或生物肽生物素的亲和力降低的突变链霉亲和素;以及一种对上述突变链霉亲和素具有高亲和力的修饰生物素.

专利信息

专利号:US-7674593-B2
优先权日:2005-12-28
标 题:Preparation method of biotinylated protein and detection method using the same
发明人：ENDO YAETA; SAWASAKI TATSUYA; MATSUBARA YUKO
权利人:CELLFREE SCIENCES CO LTD
摘要:The present invention presents construction of a detection method requiring no step of removing free biotin during preparation of a biotinylated protein having a biotin tag, in a detection method of a substance interacting with a protein, and studied various preparation methods of the biotinylated protein. In order to solve the above-mentioned problem, the present inventor has found that in a cell-free protein synthesizing system, in particular, a wheat embryo cell-free protein synthesizing system, when biotinylation is performed during or after protein's synthesis, the biotinylation of the protein can be attained in an remarkably lower concentration of the biotin than that in the conventional biotinylation operations, and has accomplished the present invention by using the protein having the biotin tag in each detection system.

专利号:US-3983134-A
优先权日:1974-08-05
标 题 :Ureylenethiophanes and their related compounds, and production thereof
发明人：MATSUI MASANAO; MORI KENJI; KITAHARA TAKESHI; KITAMURA SEIICHI; OHBA KAZUMASA
权利人:TEIKOKU CHEM IND CO LTD
摘要:Ureylenethiophanes and their related compounds of the formula: ##SPC1## n Having a cis-configuration on the ureylene or thioureylene juncture, which are useful as the intermediates in the synthesis of biologically active biotin and its related compounds, can be produced selectively by reacting the corresponding compounds of the formula: ##SPC2## n With isocyanates or isothiocyanates wherein R is a hydrogen atom, an alkyl group or an aralkyl group, R 1 and R 2 are each a hydrogen atom or an aliphatic hydrocarbon group bearing or not a carboxyl group or any other group convertible thereto at the terminal position, X is a halogen atom, Y is an oxygen atom or a sulfur atom and Z is an oxygen atom, a sulfur atom, a sulfinyl group or a sulfonyl group.

专利号:US-9295731-B2
优先权日:2013-04-01
标题 :Cleavable drug conjugates, compositions thereof and methods of use
发明人：NGUYEN MARK QUANG
权利人:NGUYEN MARK QUANG
摘要:Base-labile crosslinkers, base-labile conjugates comprising such crosslinkers, methods of their synthesis and use are disclosed.

专利号:US-4908452-A
优先权日:1987-12-21
标 题 :Process for preparing nitriles
发明人：CLAREMON DAVID A
权利人:MERCK & CO INC
摘要:A facile and mild process for the preparation of nitriles from reagent sensitive primary carboxamides is described. The process utilizes a (carboxysulfamoyl)ammonium hydroxide compound as the dehydrating agent. It is useful for preparing nitriles which have present other groups which are sensitive to the more conventional methods of dehydration or to other methods of nitrile synthesis. Some novel nitriles prepared by the new method are also described.