CAS: 1025720-94-8; N-(4-((2-Amino-3-Chloropyridin-4-yl)Oxy)-3-Fluorophenyl)-4-Ethoxy-1-(4-Fluorophenyl)-2-Oxo-1,2-Dihydropyridine-3-Carboxamide

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CAS号1025721-14-5 3-chloro-4-(4-(...

📜1,2-二氢-4-碘-2-氧代吡啶-3-甲醛置于2,6-二甲基吡啶,Sodium Chlorite,Sodium Dihydrogenphosphate,氯化亚砜,水,Copper Diacetate,Sodium Hydride,肉豆蔻酸,N,N-二异丙基乙胺体系中,用 四氢呋喃,甲苯,叔丁醇 用作溶剂,化学反应 103.5H,反应生成N-[4-[(2-氨基-3-氯吡啶-4-基)氧基]-3-氟苯基]-4-乙氧基-1-(4-氟苯基)-2-氧代-1,2-二氢吡啶-3-甲酰胺
参考文献: Phosphonate Conjugates And Uses Thereof[fr] Conjugués De Phosphonate Et Leurs Utilisations
标题: Phosphonate Conjugates And Uses Thereof[fr] Conjugués De Phosphonate Et Leurs Utilisations
摘要:磷酸酯共轭物,最好是双磷酸酯共轭物;抑制ron受体酪氨酸激酶的方法以及利用所提供的磷酸酯共轭物治疗因癌症或其他疾病导致的骨破坏的方法.

专利信息

专利号:US-10973847-B2
优先权日:2017-06-30
标题 :Core-to-surface polymerization for the synthesis of star polymers and uses thereof
发明人：JOHNSON JEREMIAH A; GOLDER MATTHEW R
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:Disclosed are methods, compositions, reagents, systems, and kits to prepare star polymers, as well as compositions and uses thereof. Various embodiments show that synthesis of these polymers contain low metal concentration to provide polymers for diverse biomedical applications including in vivo applications.

专利号:US-2017283878-A1
优先权日:2015-12-11
标题:Modulation of globoseries glycosphingolipid synthesis and cancer biomarkers
发明人：WONG CHI-HUEY; WU CHUNG-YI; CHEUNG SARAH K C; CHUANG PO-KAI; HSU TSUI-LING
权利人:ACADEMIA SINICA
摘要:The present disclosure relates to methods and compositions which can modulate the globoseries glycosphingolipid synthesis. Particularly, the present disclosure is directed to glycoenzyme inhibitor compound and compositions and methods of use thereof that can modulate the synthesis of globoseries glycosphingolipid SSEA-3/SSEA-4/GloboH in the biosynthetic pathway; particularly, the glycoenzyme inhibitors target the alpha-4GalT; beta-4GalNAcT-I; or beta-3GalT-V enzymes in the globoseries synthetic pathway. Additionally, the present disclosure is also directed to vaccines, antibodies, and/or immunogenic conjugate compositions targeting the SSEA-3/SSEA-4/GLOBO H associated epitopes (natural and modified) which elicit antibodies and/or binding fragment production useful for modulating the globoseries glycosphingolipid synthesis. Moreover, the present disclosure is also directed to the method of using the compositions described herein for the treatment or detection of hyperproliferative diseases and/or conditions. Furthermore, the instant disclosure also relates to cancer stem cell biomarkers for diagnostic and therapeutic uses.

专利号:EP-3160970-A1
优先权日:2014-06-30
标题 :Synthesis of halichondrin analogs and uses thereof