CAS: 944842-54-0; (R)-2-((2-(1H-Pyrrolo[2,3-B]Pyridin-3-yl)Pyrimidin-4-yl)Amino)-2-Methyl-N-(2,2,2-Trifluoroethyl)Butanamide

上下游产品

2-((2-(1H-Pyrrolo[2,3-B]Pyridin-3-yl)Pyrimidin-4-yl)Amino)-2-Methyl-N-(2,2,2-Trifluoroethyl)Butanamide 1417421-97-6
(R)-2-(2-(1H-Pyrrolo[2,3-B]Pyridin-3-yl)Pyrimidin-4-Ylamino)-2-Methylbutanoic Acid 1417421-82-9
2-((2-(1H-Pyrrolo[2,3-B]Pyridin-3-yl)Pyrimidin-4-yl)Amino)-2-Methylbutanoic Acid 1417421-96-5
(R)-2-Methyl-2-(2-(1-Tosyl-1H-Pyrrolo[2,3-B]Pyridin-3-yl)Pyrimidin-4-Ylamino)Butanoic Acid 1417421-80-7
Methyl 2-Methyl-2-((2-(1-Tosyl-1H-Pyrrolo[2,3-B]Pyridin-3-yl)Pyrimidin-4-yl)Amino)Butanoate 1417421-95-4
(2R)-2-[(2-Chloropyrimidin-4-yl)Amino]-2-Methyl-N-(2,2,2-Trifluoroethyl)Butanamide

(R)-2-Methyl-2-(2-(1-Tosyl-1H-Pyrrolo[2,3-B]Pyridin-3-yl)Pyrimidin-4-Ylamino)Butanoic Acid置于水,N,N-二异丙基乙胺,Potassium Hydroxide体系中,用 二氯甲烷,水 作为反应溶剂,化学反应 11.5H,反应生成 Decernotinib(vx-509)抑制剂
参考文献: Processes And Intermediates For Producing Azaindoles[fr] Procédés Et Intermédiaires Pour Produire Des Azaindoles
标题: Processes And Intermediates For Producing Azaindoles[fr] Procédés Et Intermédiaires Pour Produire Des Azaindoles

专利信息

专利号:US-2025206743-A1
优先权日:2022-03-25
标 题:Tyk2 inhibitor synthesis and intermediates thereof
发明人：MASSE CRAIG E; PHADKE AVINASH S; LAWSON JON P; LEVY STUART; YANG XIAOWEI; WU GUISHENG; FAN SHUFENG
权利人:TAKEDA PHARMACEUTICALS CO
摘要:Described herein are methods of synthesis of a tyrosine-protein kinase 2 (TYK2) inhibitor and to intermediate compounds of the synthesis and methods of making the intermediates. Also provided are pharmaceutically acceptable compositions including compounds prepared by the synthetic method and methods of treating disorders using the same.

专利号:US-10906888-B2
优先权日:2016-07-14
标 题:Pyrimidine carboxamides as inhibitors of Vanin-1 enzyme
发明人：CASIMIRO-GARCIA AGUSTIN; STROHBACH JOSEPH WALTER; HEPWORTH DAVID; LOVERING FRANK ELDRIDGE; CHOI CHULHO; ALLAIS CHRISTOPHE PHILIPPE; WRIGHT STEPHEN WAYNE
权利人:PFIZER
摘要:Compounds, pharmaceutically acceptable salts thereof, are disclosed wherein the compounds have the structure of (I) as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:US-10308615-B2
优先权日:2015-05-29
标 题:Heterocyclic compounds as inhibitors of Vanin-1 enzyme
发明人：CASIMIRO-GARCIA AGUSTIN; CONDON JEFFREY SCOTT; FLICK ANDREW CHRISTOPHER; GOPALSAMY ARIAMALA; KIRINCICH STEVEN J; MATHIAS JOHN PAUL; STROBACH JOSEPH WALTER; XIANG JASON SHAOYUN; XING LI HUANG; WANG XIAOLUN
权利人:PFIZER
摘要:Compounds, pharmaceutically acceptable salts thereof, are disclosed wherein the compounds have the structure of n nas defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:CN-118922420-A
优先权日:2022-03-25
标题 :Synthesis of TYK2 inhibitors and their intermediates

专利号:US-2018230127-A1
优先权日:2015-08-13
标题 :Bicyclic-Fused Heteroaryl Or Aryl Compounds
发明人：ANDERSON DAVID RANDOLPH; CURRAN KEVIN JOSEPH; GAVRIN LORI KRIM; GOLDBERG JOEL ADAM; LEE ARTHUR; LOWE MICHAEL DENNIS; PATNY AKSHAY; PIERCE BETSY SUSAN; SAIAH EDDINE; TRZUPEK JOHN DAVID
权利人:PFIZER
摘要:Compounds, tautomers and pharmaceutically acceptable salts of the compounds of Formula (Ia) are disclosed which are inhibitors of Interleukin-1 receptor associated kinase (IRAK4). Methods of treatment, methods of synthesis, and intermediates are also disclosed as defined in the specification.

专利号:US-2023119606-A1
优先权日:2020-02-18
标 题:Immune cell modulators
发明人：SHERDEN NATHANIEL; YU SHEN; STONER ISAAC
权利人:OCTAGON THERAPEUTICS INC
摘要:Disclosed are immune cell-selective small molecule compounds that modulate certain immune cell-specific receptors and enzymes, and methods of their synthesis and use to treat proliferative disorders.