CAS: 917-13-5; (3S,6R,9S,12R,15S,18R)-3,6,9,12,15,18-Hexaisopropyl-4,10,16-Trimethyl-1,7,13-Trioxa-4,10,16-Triazacyclooctadecane-2,5,8,11,14,17-Hexaone
该化合物是一种由各种 Fusorior 物种生产的环六二甲基苯丙胺甲型甲氧毒素,具有致癌性,有助于生物膜的腐蚀物运输,有助于其抗微生物和细胞毒性活动,Enniatin B 研究其药理的潜在应用,特别是抗生素或抗癌剂,因为它能够干扰细胞中的离子梯度,其行动机制与碱性金属离子结合,导致靶细胞的线粒体机能失调和流行性硬化,该化合物还具有毒理学研究的兴趣,因为它存在于受Fusemarium 污染的谷物作物中,Enniatin B 的分析标准用于食品安全测试和代谢研究.
- 英文名称(3S,6R,9S,12R,15S,18R)-3,6,9,12,15,18-Hexaisopropyl-4,10,16-Trimethyl-1,7,13-Trioxa-4,10,16-Triazacyclooctadecane-2,5,8,11,14,17-Hexaone
- 中文名称恩镰孢菌素 B
- IUPAC名称(3S,6R,9S,12R,15S,18R)-3,6,9,12,15,18-hexaisopropyl-4,10,16-trimethyl-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexaone
- 其它别名(3S,6R,9S,12R,15S,18R)-4,10,16-Trimethyl-3,6,9,12,15,18-Hexa(Propan-2-yl)-1,7,13-Trioxa-4,10,16-Triazacyclooctadecane-2,5,8,11,14,17-Hexone; 2,8,14-Triaza-3,6,9,12,15,18-Hexakis(Methylethyl)-2,8,14-
- CAS编号917-13-5
- MFCD编号:MFCD00236425
- EINECS号:695-639-0
- FDA UNII编号:H02S2TZR95
- 分子式:C33H57N3O9分子量:639.83
- 产品CID: 1955030
- 产品分类天然产物 → 生物碱
物理性质
MSDS等安全信息
欧盟法规
C&L通报上下游产品
34H54N2O9C34H54N2O9 38H67N3O12C38H67N3O12 33H59N3O10*ClHC33H59N3O10*ClH 27H48N2O9C27H48N2O9(3S,6R)-3,6-diisopropyl-4-methyl-2,5-morpholinedione合成工艺路线路线简述
📜Boc-D-缬氨酸置于盐酸,4-二甲氨基吡啶,1-氯-N,N,2-三甲基丙烯胺,Palladium 10% On Activated Carbon,氢气,Sodium Hydride,盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺体系中,用 四氢呋喃,1,4-二氧六环,二氯甲烷,乙酸乙酯,Mineral Oil 作为反应溶剂,20.0 °C,101.33 Kpa 条件下,反应 2.75H,反应生成 恩镰孢菌素 B
参考文献:铵离子载体,(-)-烯属腺苷b的全合成
标题:铵离子载体,(-)-烯属腺苷b的全合成
摘要:描述了九步法(最长线性)批量合成环状六肽(-)-烯属腺苷b.该合成使反应条件期间的沉淀最小化,以适应流动合成.该途径用于制备＞ 100Mg的天然产物.
DOI:10.1016/j.Tetlet.2012.05.110
海关参考信息
- 2905122000-异丙醇
2909110000-乙醚
2912110000-甲醛
2912120000-乙醛 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-6991919-B1
优先权日:1999-03-17
标题:Biochemical synthesis apparatus
发明人：PORTER NEIL; GIAQUINTO FRANCES MARY
权利人:BIODIVERSITY LTD
摘要:A biochemical synthesis apparatus comprises a receptacle for containing a medium, and a support on which a microorganism can be placed. The support can be placed in contact with the medium, so as to allow access of the microorganism to the medium. The support with the microorganism can be removed from the medium, allowing the medium to be replaced. By this, the receptacle can firstly contain a growth medium, and secondly a secondary medium capable of causing the production by the microorganism of a potentially useful biochemical.
专利号:DE-19726012-C1
优先权日:1997-06-19
标题 :Process for the preparation of cyclopeptides and cyclodepsipeptides by enzymatic synthesis
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
摘要:S109 | PARCEDC | List of 7074 potential endocrine disrupting compounds (EDCs) by PARC T4.2 | DOI:10.5281/zenodo.10944198
摘要:A3056: Watjen W, Debbab A, Hohlfeld A, Chovolou Y, Kampkotter A, Edrada RA, Ebel R, Hakiki A, Mosaddak M, Totzke F, Kubbutat MH, Proksch P: Enniatins A1, B and B1 from an endophytic strain of Fusarium tricinctum induce apoptotic cell death in H4IIE hepatoma cells accompanied by inhibition of ERK phosphorylation. Mol Nutr Food Res. 2009 Apr;53(4):431-40. doi: 10.1002/mnfr.200700428.
摘要:A3055: Hyun U, Lee DH, Lee C, Shin CG: Apoptosis induced by enniatins H and MK1688 isolated from Fusarium oxysporum FB1501. Toxicon. 2009 Jun;53(7-8):723-8. doi: 10.1016/j.toxicon.2009.02.012. Epub 2009 Feb 25.
参考文献:10.1021/np0340448
摘要:Pohanka A, Capieau K, Broberg A, Stenlid J, Stenström E, Kenne L. Enniatins ofFusariumsp. Strain F31 and Their Inhibition ofBotrytiscinereaSpore Germination. J. Nat. Prod. 2004 Apr 28;67(5):851–7. doi: 10.1021/np0340448.
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