CAS: 81029-03-0; 1-Methoxy-2,3-Dimethyl-4-Nitrobenzene

上下游产品

2,3-dimethylanisole tetranitromethane 2,3-dimethyl-4-nitrophenol 2,3-dimethyl-4-methoxyaniline 2,3-bis-bromomethyl-1-methoxy-4-nitro-benzene 6-methoxy-2-methyl-3-nitrobenzyl acetate

📜2,3-二甲基苯甲醚置于硝酸,溶剂黄146体系中,化学反应 18.0H,以40%的收率获得产物2,3-二甲基-4-硝基苯甲醚
参考文献:A Switchable Oxidation Process Leading To Two Various Versatile Pharmaceutical Intermediates
标题:A Switchable Oxidation Process Leading To Two Various Versatile Pharmaceutical Intermediates
摘要:An Efficient High-Yielding And Environmentally Benign Switchable Oxidation Process That Can Selectively Produce Two Different Versatile Synthetic Intermediates Is Disclosed. One Of The Two Intermediates,2,3-Dimethoxy-5-Methylcyclohexa-2,5-Diene-1,4-Dione (Coenzyme Q(0)),Is Obtained By Menu Of A Telescoped Two-Step Synthetic Protocol That In The First Step Involves Treatment Of The Substrate (1,2,3-Trimethoxy-5-Methylbenzene) With Hydrogen Peroxide In Acetic Acid With P-Toluene Sulphonic Acid Present As A Bronsted Acid Catalyst,Succeeded By A Telescoped Second Step That Entails Treatment With Fuming Nitric Acid To Achieve The Target Molecule In An Excellent Isolated Yield (88%). If The Substrate Is Treated Directly With Nitric Acid (659) In Glacial Acetic Acid Two Different Products Can Be Obtained,Namely Acetic Acid 3,4,5-Trimethoxybenzyl Ester In A Superb Isolated Yield (93%) Or,Under Slightly Altered Reaction Conditions,1,2,3-Trimethoxy-5-(Nitromethyl)Benzene In A Moderate To Low Yield (35%) And Low Selectivity. The Two Pathways Leading To The Two Different Products In The Nitric Acid Oxidation Protocol Were Investigated By Means Of Dft Calculations As An Aid To Elaborate A Proposal For The Reaction Mechanism.
DOI:10.1021/op100185X

专利信息

专利号:US-2025101038-A1
优先权日:2021-12-24
标 题 :Compounds
发明人：BANISTER SAMUEL; JORGENSEN WILLIAM; TAN JINLONG
权利人:Psylo Pty Ltd
摘要:The present disclosure relates generally to compounds, their methods of synthesis, and their use in the treatment of mental illness or central nervous system disorders.