CAS: 7699-31-2; 1,2-Diethylhydrazine Dihydrochloride

该化合物是一种有机化合物,其特征是水合金脊柱,其两个乙基组附于氮原子,形成二乙基氨结构;作为盐酸盐,通常以晶状形式出现,在水中溶解,可增强其在各种化学应用中的用途;该化合物因其特性减少而闻名,经常用于合成药品,农用化学品和火箭推进剂;该化合物具有中等毒性,在接触时可能对健康造成危害,因此在操作过程中必须采取适当的安全措施;该化合物的再活性受水合物功能组的存在影响,该功能组可参与各种化学反应,包括氧化和凝聚;此外,必须指出,氢合金衍生物对热和冲击十分敏感,因此对防止危险情况具有必要的适当储存和处理.

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    专利信息


    专利号:US-6465693-B2
    优先权日:1998-02-26
    标 题 :Metal-catalyzed arylations of hydrazines, hydrazones, and related substrates
    发明人:BUCHWALD STEPHEN L; WAGAW SEBLE; GEIS O
    权利人:MASSACHUSETTS INST TECHNOLOGY
    摘要:A method is provided for the transition metal-catalyzed arylation, or vinylation, of hydrazines, hydrazones, and the like. Additionally, the invention provides a conceptually novel strategy, the cornerstone of which is the transition metal-catalyzed arylation or vinylation method, for the synthesis of indoles, carbazoles, and the like. The methods and strategies of the invention may be utilized in standard, parallel, and combinatorial synthetic protocols.

    专利号:EP-1058678-B1
    优先权日:1998-02-26
    标 题:Metal-catalyzed arylations and vinylations of hydrazines, hydrazones, hydroxylamines and oximes
    发明人:BUCHWALD STEPHEN L; WAGAW SEBLE; GEIS OLIVER
    权利人:MASSACHUSETTS INST TECHNOLOGY
    摘要:A method is provided for the transition metal-catalyzed arylation, or vinylation, of hydrazines, hydrazones, and the like. Additionally, the invention provides a conceptually novel strategy, the cornerstone of which is the transition metal-catalyzed arylation or vinylation method, for the synthesis of indoles, carbazoles, and the like. The methods and strategies of the invention may be utilized in standard, parallel, and combinatorial synthetic protocols.

    专利号:US-4358599-A
    优先权日:1980-08-07
    标 题 :Synthesis of 4-amino-1,2-hydrocarbyl pyrazolidines via 4-nitro analogs
    发明人:LO YOUNG SEK; MUNSON HARRY RANDALL JR
    权利人:ROBINS CO INC A H
    摘要:4-Nitro-1,2-hydrocarbyl pyrazolidines are prepared by a novel route from 1,2-disubstituted hydrazines and 1,3-di-(secondary amino)-2-nitropropanes and reduced to the corresponding 4-amino-1,2-hydrocarbyl pyrazolidines, which latter compounds are intermediates in the preparation of certain pharmaceutical benzamides. n The novel 4-nitro-1,2-hydrocarbyl pyrazolidines have the formula: ##STR1## wherein R 1 and R 2 are selected from loweralkyl, lowercycloalkyl or phenyl-loweralkyl and may be the same or different.

    专利号:US-4309552-A
    优先权日:1980-08-07
    标 题:Synthesis of 4-nitro-1,2-hydrocarbyl pyrazolidines and process for preparation thereof
    发明人:LO YOUNG SEK; MUNSON HARRY RANDALL JR
    权利人:ROBINS CO INC A H
    摘要:4-Nitro-1,2-hydrocarbyl pyrazolidines are prepared by a novel route from 1,2-disubstituted hydrazines and 1,3-di-(secondary amino)-2-nitropropanes and reduced to the corresponding 4-amino-1,2-hydrocarbyl pyrazolidines, which latter compounds are intermediates in the preparation of certain pharmaceutical benzamides. n The novel 4-nitro-1,2-hydrocarbyl pyrazolidines have the formula: ##STR1## wherein R 1 and R 2 are selected from loweralkyl, lowercycloalkyl or phenyl-loweralkyl and may be the same or different.

    专利号:IE-51530-B1
    优先权日:1980-08-07
    标 题 :4-nitro-1,2-hydrocarbyl-pyrazolidines and methods of synthesis of 4-amino analogues therefrom

    专利号:GB-2081713-A
    优先权日:1980-08-07
    标题 :4-nitro-1,2-hydrocarbyl-pyrazolidines and methods of synthesis of 4-amino analogues therefrom

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    主要参考文献

    [参考文献]: Yuhong Ju, Et Al. Aqueous N-Heterocyclization Of Primary Amines And Hydrazines With Dihalides: Microwave-Assisted Syntheses Of N-Azacycloalkanes, Isoindole, Pyrazole, Pyrazolidine, And Phthalazine Derivatives. J Org Chem. 2006 Jan 6;71(1):135-41.

    合成参考文献


    摘要:2024 Emergency Response Guidebook,
    摘要:National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.
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