专利号:US-6465693-B2 优先权日:1998-02-26 标 题 :Metal-catalyzed arylations of hydrazines, hydrazones, and related substrates 发明人:BUCHWALD STEPHEN L; WAGAW SEBLE; GEIS O 权利人:MASSACHUSETTS INST TECHNOLOGY 摘要:A method is provided for the transition metal-catalyzed arylation, or vinylation, of hydrazines, hydrazones, and the like. Additionally, the invention provides a conceptually novel strategy, the cornerstone of which is the transition metal-catalyzed arylation or vinylation method, for the synthesis of indoles, carbazoles, and the like. The methods and strategies of the invention may be utilized in standard, parallel, and combinatorial synthetic protocols.
专利号:EP-1058678-B1 优先权日:1998-02-26 标 题:Metal-catalyzed arylations and vinylations of hydrazines, hydrazones, hydroxylamines and oximes 发明人:BUCHWALD STEPHEN L; WAGAW SEBLE; GEIS OLIVER 权利人:MASSACHUSETTS INST TECHNOLOGY 摘要:A method is provided for the transition metal-catalyzed arylation, or vinylation, of hydrazines, hydrazones, and the like. Additionally, the invention provides a conceptually novel strategy, the cornerstone of which is the transition metal-catalyzed arylation or vinylation method, for the synthesis of indoles, carbazoles, and the like. The methods and strategies of the invention may be utilized in standard, parallel, and combinatorial synthetic protocols.
专利号:US-4358599-A 优先权日:1980-08-07 标 题 :Synthesis of 4-amino-1,2-hydrocarbyl pyrazolidines via 4-nitro analogs 发明人:LO YOUNG SEK; MUNSON HARRY RANDALL JR 权利人:ROBINS CO INC A H 摘要:4-Nitro-1,2-hydrocarbyl pyrazolidines are prepared by a novel route from 1,2-disubstituted hydrazines and 1,3-di-(secondary amino)-2-nitropropanes and reduced to the corresponding 4-amino-1,2-hydrocarbyl pyrazolidines, which latter compounds are intermediates in the preparation of certain pharmaceutical benzamides. n The novel 4-nitro-1,2-hydrocarbyl pyrazolidines have the formula: ##STR1## wherein R 1 and R 2 are selected from loweralkyl, lowercycloalkyl or phenyl-loweralkyl and may be the same or different.
专利号:US-4309552-A 优先权日:1980-08-07 标 题:Synthesis of 4-nitro-1,2-hydrocarbyl pyrazolidines and process for preparation thereof 发明人:LO YOUNG SEK; MUNSON HARRY RANDALL JR 权利人:ROBINS CO INC A H 摘要:4-Nitro-1,2-hydrocarbyl pyrazolidines are prepared by a novel route from 1,2-disubstituted hydrazines and 1,3-di-(secondary amino)-2-nitropropanes and reduced to the corresponding 4-amino-1,2-hydrocarbyl pyrazolidines, which latter compounds are intermediates in the preparation of certain pharmaceutical benzamides. n The novel 4-nitro-1,2-hydrocarbyl pyrazolidines have the formula: ##STR1## wherein R 1 and R 2 are selected from loweralkyl, lowercycloalkyl or phenyl-loweralkyl and may be the same or different.
专利号:IE-51530-B1 优先权日:1980-08-07 标 题 :4-nitro-1,2-hydrocarbyl-pyrazolidines and methods of synthesis of 4-amino analogues therefrom
专利号:GB-2081713-A 优先权日:1980-08-07 标题 :4-nitro-1,2-hydrocarbyl-pyrazolidines and methods of synthesis of 4-amino analogues therefrom
[参考文献]: Yuhong Ju, Et Al. Aqueous N-Heterocyclization Of Primary Amines And Hydrazines With Dihalides: Microwave-Assisted Syntheses Of N-Azacycloalkanes, Isoindole, Pyrazole, Pyrazolidine, And Phthalazine Derivatives. J Org Chem. 2006 Jan 6;71(1):135-41.
合成参考文献
摘要:2024 Emergency Response Guidebook, 摘要:National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.