CAS: 73013-68-0; 6-Acetylquinoline

该化合物是一种有机化合物,其特征是松软性动物,有助于其芳香特性和潜在的生物活动;该化合物的特点是一个科酮功能组,具体为乙酮结构,附属于quinoline环系,配有乙酮结构,常常带来有趣的药理特性,使其成为药物化学的一个主题;典型的情况是,1-(6-基努林基)乙酮等化合物由于其芳香性而表现出中度到高脂性,可影响其溶性以及生物系统中的易渗透性;此外,该化合物可能参与各种化学反应,例如核分裂性替代或减少,因为碳基系组的再活性;其潜在应用可能跨越诸如药物开发等领域,在这些领域,经常探索quinoline衍生物的抗微生物,抗炎性,抗炎炎性或抗癌性特性.然而,具体的安全性和处理准则应当作为化学特性,并遵循.

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合成工艺路线路线简述

    📜喹啉-6-甲醛置于chromium(Vi) Oxide,乙醚,溶剂黄146体系中,化学反应生成 6-乙酰基喹啉
    参考文献:Lugowkin,Zhurnal Obshchei Khimii,1955,Vol. 25,P. 392,393; Engl. Ausg. S. 371,372
    标题:Lugowkin,Zhurnal Obshchei Khimii,1955,Vol. 25,P. 392,393; Engl. Ausg. S. 371,372

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    专利信息


    专利号:US-8513241-B2
    优先权日:2008-03-28
    标题 :3,4-dihydro-2H-pyrazino[1,2-A]indol-1-one derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
    发明人：CERVI GIOVANNI; D ANELLO MATTEO; PAPEO GIANLUCA MARIANO ENRICO; SALOM BARBARA
    权利人:CERVI GIOVANNI; D ANELLO MATTEO; PAPEO GIANLUCA MARIANO ENRICO; SALOM BARBARA; NERVIANO MEDICAL SCIENCES SRL
    摘要:Compounds which are 3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one derivatives or pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, viral infection, prevention of AIDS development in HIV-infected individuals, cell proliferative disorders, autoimmune and neurodegenerative disorders; also disclosed is a process under Solid Phase Synthesis conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.

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    主要参考文献

    参考标题:Assembly Of Diversely Substituted Quinolines Via Aerobic Oxidative Aromatization From Simple Alcohols And Anilines
    作者:Jixing Li,Jinlong Zhang,Huameng Yang,Gaoxi Jiang |发布日期:2017.3.17
    摘要:Acid Catalytic System Has Been Established, Providing A Direct Approach For The Preparation Of Diverse Substituted Quinoline Derivatives In High Yields With Wide Functional Group Tolerance. Practically, The Protocol Can Be Easily Scaled Up To Gram-Scale And Was Utilized In The Concise Formal Synthesis Of A Promising Herbicide Candidate.
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