CAS: 70-30-4; Hexachlorophene

该化合物是一种主要用于抗食谱配方和个人护理产品的合成抗微生物剂,其特点是白色晶状固体,可溶于有机溶剂,但水溶性有限;六氯苯的化学结构具有双联核心,其六氯原子在各种位置上被替换,有助于其强大的抗菌特性,特别是抗模性细菌的抗菌特性;由于其有效性,它历来被用于医疗和家庭感染者;然而,由于担心其...

结构式图片

欧盟法规

统一分类与标签ECHA物质工作场所安全标识要求ECHA物质化妆品禁用物质清单C&L通报REACH预注册废弃物危险特性清单

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CAS号50-00-0 甲醛 | CAS号95-95-4 2,4,5-三氯苯酚 | CAS号7664-93-9 硫酸 | CAS号2467-02-9 2,2'-二羟基二苯甲烷

合成工艺路线路线简述

    聚合甲醛,2,4,5-三氯苯酚置于硫酸体系中,化学反应生成 灭菌酚
    参考文献:Ioffe; Sal'Manowitsch,Zhurnal Obshchei Khimii,1959,Vol. 29,P. 2685,2688; Engl. Ausg. S. 2652,2654
    标题:Ioffe; Sal'Manowitsch,Zhurnal Obshchei Khimii,1959,Vol. 29,P. 2685,2688; Engl. Ausg. S. 2652,2654

    海关参考信息

    专利信息


    专利号:US-2014255328-A1
    优先权日:2013-03-11
    标 题:Hydrothermal Synthesis of Zinc Phlogopite
    发明人:MCGUIRE MEAGHAN CLARK; BULL IVOR; JOHNSON GEOFFREY MARK
    权利人:BASF SE
    摘要:This invention relates to a synthetically derived zinc phlogopite platelets, of superior platelet diameter, effect pigments comprising such synthetically derived platelets and methods of forming said substrates. More specifically the disclosure describes an improved hydrothermal synthesis of zinc phlogopite suitable as a platelets for interference pigments, barrier and flame retardant applications.

    专利号:US-2017268027-A1
    优先权日:2014-12-22
    标题:Method for synthesis of fatty acids
    发明人:CESCUT JULIEN; URIBELARREA JEAN-LOUIS; GUILLOUET STEPHANE; MOLINA-JOUVE CAROLE; SAGNAK RANA
    权利人:INST NAT DES SCIENCES APPLIQUEES DE TOULOUSE; CENTRE NAT RECH SCIENT; AGRONOMIQUE INST NAT RECH; FIDOP (FONDS DE DEV DES FILIERES DES OLEAGINEUX ET DES PROTEAGINEUX)
    摘要:Disclosed is a method for synthesis of fatty acids by culturing a eukaryotic microorganism from the fungi kingdom, that is naturally oleaginous or rendered oleaginous. The culture is performed in the presence a fatty acid synthase inhibitor in the culture medium.

    专利号:US-8557979-B2
    优先权日:2004-06-10
    标题 :Carbapenem antibacterials with gram-negative activity and processes for their preparation
    发明人:CHOI WOO-BAEG; KOWALIK EWA
    权利人:CHOI WOO-BAEG; KOWALIK EWA; FOB SYNTHESIS INC
    摘要:The present invention provides β-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment. The present invention is also in the field of synthetic organic chemistry and is specifically provides an improved method of synthesis of β-methyl carbapenems which are useful as antibacterial agents.

    专利号:US-10933051-B2
    优先权日:2017-06-09
    标 题 :Carbapenem compounds and compositions for the treatment of bacterial infections
    发明人:CHOI WOO-BAEG; TOMIOKA TAKASHI; JOO HYUNG-YEUL; TRUONG PHONG; MIN BRIAN
    权利人:FOB SYNTHESIS INC
    摘要:The present invention provides carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections, including drug resistant or multiple-drug resistant bacterial infections, and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment.

    专利号:US-2022072026-A1
    优先权日:2018-12-24
    标题:Treatment of spinal conditions with chimera decoy
    发明人:MASUDA KOICHI; NAKAZAWA TAKAHIRO
    权利人:UNIV CALIFORNIA; ANGES INC
    摘要:Provided herein are methods and compositions for treating spinal conditions. In particular, use of double-stranded oligonucleotide decoys capable of binding to the DNA binding sites of two transcription factors (NF-κB and STAT6) for treatment of intervertebral disc degeneration, regenerating a chondrocyte extracellular matrix, spinal pain, and promoting synthesis of proteoglycan in intervertebral disc cells.

    专利号:US-4767875-A
    优先权日:1985-09-09
    标 题:Process for synthesis of aluminum coordinations compounds
    发明人:VINCENTI PAUL J; WARREN JAMES D
    权利人:AMERICAN CYANAMID CO
    摘要:A method for producing heterocyclic aluminum compounds of the formula: where n is 0 to 1, by reacting aluminum chloride with an aliphatic polyhydric alcohol having from 2 to 6 carbon atoms and having hydrogen, hydroxy, or low alkyl groups on carbon atoms which are spaced apart by no more than one intervening carbon atom, which is useful as an anti-perspirant.
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    二-(2-羟基-3,5,6-三氯苯基)甲烷
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    主要参考文献


    1: Ansari A, Kumar D, Gupta P, Poluri KM, Rai N, Ameen F, Kumar N. Mechanistic insights into antifungal potential of Alexidine dihydrochloride and hexachlorophene in Candida albicans: a drug repurposing approach. Arch Microbiol. 2024 Aug 20;206(9):383. doi: 10.1007/s00203-024-04103-3. 19(8):e0307669. doi: 10.1371/journal.pone.0307669.
    3: Liachenko S, Sarkar S. In vivo mapping of rat brain partial white matter content using hexachlorophene-induced neurotoxicity model. Brain Res. 2024 May 1;1830:148811. doi: 10.1016/j.brainres.2024.148811. Epub 2024 Feb 15.
    441:115988. doi: 10.1016/j.taap.2022.115988. Epub 2022 Mar 18. 48(8):965-980. doi: 10.1177/0192623320968210. Epub 2020 Dec 2.

    合成参考文献


    参考文献:10.1155/2011/859020
    摘要:Wesner AR, Brackbill ML, Sytsma CS. Effect of Preoperative N-Acetylcysteine on Postoperative Blood Loss Parameters in Cardiac Surgery Patients. International Journal of Vascular Medicine. 2011;2011():1–5. doi: 10.1155/2011/859020.
    参考文献:10.1186/1749-8090-6-91
    摘要:Rottenberg EM, Heard J, Hamlin R, Sun BC, Awad H. Abdominal only CPR during cardiac arrest for a patient with an LVAD during resternotomy: A case report. Journal of Cardiothoracic Surgery. 2011 Jul 15;6(1):91. doi: 10.1186/1749-8090-6-91.
    参考文献:10.1093/ecam/neq015
    摘要:Ng MCS, Jones AYM, Cheng LC. The Role of Acu‐TENS in Hemodynamic Recovery after Open‐Heart Surgery. Evidence-Based Complementary and Alternative Medicine. 2011 Jan;2011(1). doi: 10.1093/ecam/neq015.
    参考文献:10.1007/s11517-011-0813-4
    摘要:Ciocca L, Fantini M, De Crescenzio F, Corinaldesi G, Scotti R. Direct metal laser sintering (DMLS) of a customized titanium mesh for prosthetically guided bone regeneration of atrophic maxillary arches. Medical & Biological Engineering & Computing. 2011 Jul 21;49(11):1347–52. doi: 10.1007/s11517-011-0813-4.
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