CAS: 6326-44-9; Diethyl 2-Formamidomalonate

相似化合物

102831-44-7 1068-90-2 3005-66-1

上下游产品

CAS号6829-40-9 氨基丙二酸二乙酯 | CAS号122-51-0 原甲酸三乙酯 | CAS号6829-41-0 异亚硝基丙二酸二乙酯 | CAS号109-94-4 甲酸乙酯 | CAS号91469-69-1 Propanedioic ac... | CAS号64-18-6 甲酸 | CAS号105-53-3 丙二酸二乙酯 | CAS号14423-15-5 ethyl 5-ethoxy-... | CAS号82372-74-5 4-叔丁基苯丙氨酸 | CAS号609-36-9 DL-脯氨酸 | CAS号6829-40-9 氨基丙二酸二乙酯 | CAS号66866-40-8 7-苄氧基-DL-色氨酸 | CAS号150-30-1 DL-苯丙氨酸 | CAS号617-65-2 DL-谷氨酸 | CAS号17702-88-4 2-氨基癸酸 | CAS号119695-00-0 diethyl 2-amino... | CAS号7145-00-8 2-amino-4-bromo...

丙二酸2-氨基-1-乙酯置于盐酸体系中,用 水 作为反应溶剂,化学反应 8.0H,反应生成 甲酰氨基丙二酸二乙酯
参考文献:Peroxisome Proliferator-Activated Receptor-γ Mediates The Anti-Inflammatory Effect Of 3-Hydroxy-4-Pyridinecarboxylic Acid Derivatives: Synthesis And Biological Evaluation
标题:Peroxisome Proliferator-Activated Receptor-γ Mediates The Anti-Inflammatory Effect Of 3-Hydroxy-4-Pyridinecarboxylic Acid Derivatives: Synthesis And Biological Evaluation
摘要:Seven 3-Hydroxy-4-Pyridinecarboxylic Acid Derivatives (Hps),Aza-Analogues Of Salicylic Acid And Structurally Close To Other Potent Inflammatory Pyridine Compounds Such As Aminopyridinylmethanols And Aminopyridinamines,Were Synthesized,And Their Anti-Inflammatory Activity Was Evaluated. The Synthesis Was Performed By Adopting A General Procedure Involving An Intramolecular Diels-Alder Cycloaddition Of Oxazoles With Acrylic Acid To Form Various Substituted Pyridinic Acids. The Newly Synthesized Hps Did Not Exhibit Cytotoxic Activity On Human Monocytes-Derived Macrophages At Concentrations Up To 10(2) Mu M. Anti-Inflammatory Activity Of The Compounds Was Screened In Vitro By Evaluating The Capability To Inhibit Cytokines Release From Lipopolysaccharide (Lps) Stimulated Human Macrophages. 3-Hydroxy-1-Methyl-4-Pyridinecarboxylic Acid (24) Was Found To Be The Most Active Hp. At 10 Mu M Concentration,Hp 24 Reduced Lps-Induced And Nuclear Factor-Kappa B Activation And Cyclooxygenase-2 Expression,While Increased Intracellular Reactive Oxygen Species Generation And Peroxisome Proliferator-Activated Receptor (Ppar-Gamma) Mrna Transcript Level. Indeed,Pre-Treatment Of Lps-Exposed Human Macrophages With Ppar-Gamma Specific Antagonist Completely Prevented Hp 24-Induced Tnf-Alpha And Il8 Down Regulation,Demonstrating That The Ppar Gamma Pathway Is Mandatory For The Hp 24 Anti-Inflammatory Effect. Finally,Daily Treatment With Hp 24 Ameliorated The Outcome Of Dss-Induced Colitis In Mice,Significantly Reducing Colonic Mpo Activity And Il-1 Beta Tissue Levels. (C) 2013 Elsevier Masson Sas. All Rights Reserved.
DOI:10.1016/j.Ejmech.2013.01.024

专利信息

专利号:US-3676458-A
优先权日:1970-06-11
标题:(indolymethyl) malonate compound
发明人：KORNFELD EDMUND CARL
权利人:LILLY CO ELI
摘要:6-(Trifluoromethyl)tryptophane, useful as a non-nutritive sweetening agent and also useful in the synthesis of a corresponding pyrrolnitrin derivative; and intermediates useful in the synthesis of 6-(trifluoromethyl)tryptophane.

专利号:US-4073795-A
优先权日:1976-06-22
标 题:Synthesis of tryptophans