专利号:US-12281348-B2 优先权日:2020-11-08 标 题:Method for the continuous flow synthesis of (R)-4-halo-3-hydroxy-butyrate 发明人:CHEN FENER; CHENG DANG; HUANG ZEDU; LIU MINJIE; HUANG HUASHAN; JIANG MEIFEN; WANG LULU 权利人:UNIV FUDAN 摘要:This application relates to organic synthesis, and more particularly to a method for the continuous flow synthesis of (R)-4-halo-3-hydroxy-butyrate using a micro-reaction system. This application performs an enzymatic asymmetric reduction of a substrate solution containing halogenated acetoacetate and a biocatalyst solution in the micro-reaction system composed of a micro-mixer, a micro-channel reactor, and a pH regulator to obtain the (R)-4-halo-3-hydroxy-butyrate. Compared to the prior art, the reaction time of the method is only a few minutes, the yield of the product (R)-4-halo-3-hydroxy-butyrate is greater than 95%, the reaction process is continuous, the degree of automation is high, the efficiency is high, and the process is simple to operate and easy to be used in industrialized production.
专利号:US-6096898-A 优先权日:1999-10-22 标 题:One pot synthesis of 1,2,4-triazoles 发明人:PODHOREZ DAVID E; HULL JR JOHN W; BRADY CHRISTINE H 权利人:DOW AGROSCIENCES LLC 摘要:One pot synthesis of 1,2,4-triazoles uses thioimidate intermediate and 1,2-dichloroethane solvent.
专利号:US-2025034146-A1 优先权日:2023-07-13 标题:Electro-photochemical synthesis of 1,2,4-triazolo-[4,3-a]pyrazine 发明人:PIERCEY DAVIN GLENN; YOUNT JOSEPH ROBERT 权利人:PURDUE RESEARCH FOUNDATION 摘要:A method of preparing a 1,2,4-triazolo-[4,3-a]pyrazine backbone using an electro-photochemical process comprising coupling a compound comprising a 5-substituted tetrazole moiety to a compound comprising an optionally substituted pyrazine moiety electrochemically and subjecting the resulting compound to photochemical excitation with ultraviolet light.
专利号:US-7153960-B2 优先权日:2001-12-10 标 题:Synthesis of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones 发明人:ZHOU JIACHENG; OH LYNETTE M; MA PHILIP; LI HUI-YIN; CONFALONE PASQUALE 权利人:BRISTOL MYERS SQUIBB CO 摘要:A novel process and intermediates thereof for making 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones of the type shown below from appropriate phenyl hydrazines is described. n nThese compounds are useful as factor Xa inhibitors.
专利号:US-6441219-B1 优先权日:1999-07-15 标 题 :Process for the preparation of 5-and/or 6-substituted-2-hydroxybenzoic acid esters 发明人:DOEHNER JR ROBERT FRANCIS 权利人:BASF CORP 摘要:There is provided a single-step process for the preparation of a compound of formula I. n Compounds of formula I are useful as starting materials in the synthesis of natural products and in the manufacture of benzophenone fungicidal agents.
专利号:US-6559336-B2 优先权日:1999-07-15 标 题:Process for the preparation of 5- and/or 6-substituted-2-hydroxybenzoic acid esters 发明人:PFRENGLE ANDREAS; SCHEFFER ROBERT J H; SCHEIBLICH STEFAN; WEVERS JAN HENDRIK; VOGELBACHER UWE JOSEF; DOEHNER ROBERT F 权利人:BASF AG 摘要:There is provided a single-step process for the preparation of a compound of formula I.Compounds of formula I are useful as starting materials in the synthesis of natural products and in the manufacture of benzophenone fungicidal agents.
1: Flanagan PM, Fennewald MA. Analysis of inhibitors of the site-specific recombination reaction mediated by Tn3 resolvase. J Mol Biol. 1989 Mar 20;206(2):295-304.
合成参考文献
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