CAS: 59571-75-4; Methyl 2-O-(α-D-Mannopyranosyl)-α-D-Mannopyranoside

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(2R,3S,4S,5S,6S)-2-(hydroxymethyl)-6-methoxytetrahydro-2H-pyran-3,4,5-triol 4-nitrophenyl-α-D-mannopyranoside guanosine 5'-diphospho-D-mannose methanol -α-D-mannopyranosidemethyl 6-O-(diphenoxy)phosphoryl-2-O-6-O-(diphenoxy)phosphoryl-α-D-mannopyranosyl-α-D-mannopyranoside

📜2,3,4,6-四-O-乙酰基-1-溴-Alpha-D-甘露糖置于palladium On Activated Charcoal 4 A Molecular Sieve,氢气,Sodium Methylate,氰化汞,Mercury Dibromide体系中,用 甲醇,乙醇,溶剂黄146,乙腈 作为反应溶剂,25.0 °C,350.0 Kpa 条件下,反应 8.0H,反应生成 а1,2-单甘露醇,а甲基糖苷
参考文献:Lysosomal-Enzyme Targeting: The Phosphorylation Of Synthetic D-Mannosyl Saccharides By Udp-N-Acetylglucosamine:Lysosomal-Enzyme N-Acetylglucosaminephosphotransferase From Rat-Liver Microsomes And Fibroblasts
标题:Lysosomal-Enzyme Targeting: The Phosphorylation Of Synthetic D-Mannosyl Saccharides By Udp-N-Acetylglucosamine:Lysosomal-Enzyme N-Acetylglucosaminephosphotransferase From Rat-Liver Microsomes And Fibroblasts
摘要:Phosphorylation Of The D-Mannose Residues Of Lysosomal Enzymes Is Essential For The Uptake And Intracellular Transport Of These Enzymes To Lysosomes. The Glcnac-P-Transferase Which Is Involved In The Phosphorylation Reaction Seems To Recognize A Signal,Probably A Protein Conformation,Common To Many Lysosomal Enzymes. To Evaluate The Role Of The Carbohydrate Portion Of The Enzyme In These Phosphorylation Reactions,The Acceptor Specificity Of Glcnac-P-Transferase From Rat-Liver Microsomes And Fibroblasts Was Examined With The Aid Of Synthetic D-Mannosyl Disaccharides And Derivatives That Are Closely Related To The High-Mannose Type Of Oligosaccharides. Four Methyl D-Mannobiosides Were Synthesized,And Their Structures Were Established By 13C-N.M.R. Spectroscopy. Of All The D-Mannosyl Saccharides Tested,Alpha-D-Man-(1----2)-Alpha-D-Man-(1----Ome) Was Found To Be The Best Acceptor,Thereby Suggesting That Oligosaccharide Structure May Also Have A Role To Play In Recognition By This Enzyme.
DOI:10.1016/s0008-6215(00)90298-2

专利信息

专利号:US-4918009-A
优先权日:1985-12-11
标 题:Method of controlling the regioselectivity of glycosidic bonds
发明人：NILSSON KURT G I
权利人:SVENSKA SOCKERFABRIKS AB
摘要:A method of controlling the regioselectivity of the glycosidic bond between glycosyl donor and glycosyl acceptor in the enzymatic production of an oligosaccharide compound which either consists of or is a fragment or an analog of the cabohydrate part in a glycoconjugate, by reverse hydrolysis or transglycosidation reactions, is described. The synthesis is carried out in that a donor substance which is a mono- or oligosaccharide or a glycoside thereof, is caused to react, in the presence of a glycosidase, with an acceptor substance which is an O-, N-, C- or S-glycoside consisting of a monosaccharide, oligosaccharide or a saccharide analog and at least one aglycon which is O-, N-, C- or S-glycosidically bonded in 1-position, the alpha or beta -configuration being selected on the glycoside bond between the glycosyl group and the aglycon in the acceptor substance, and the oligosaccharide compound being separated from the reaction mixture.