CAS: 58859-46-4; Ethyl 4-Amino-1-Piperidinecarboxylate

相似化合物

120278-07-1 206273-87-2 53786-43-9

上下游产品

CAS号29976-53-2 N-乙氧羰基-4-哌啶酮 | CAS号107618-03-1 3-(哌啶-4-基)-1H-咪... | CAS号53786-10-0 4-(2-酮基-3-甲基-1-... | CAS号53786-45-1 4-((2-氨基-4-氯苯基)... | CAS号53786-28-0 5-氯-1-(4-哌啶子基)-... | CAS号84501-68-8 4-[[1-[(4-氟苯基)甲... | CAS号100460-87-5 1-(4-氟苄基)-1H-苯并... | CAS号20662-53-7 4-(2-酮酸-1-苯并咪唑)哌啶 | CAS号185961-99-3 1-(哌啶-4-基)-1H-咪... | CAS号73733-70-7 ethyl 4-isothio... | CAS号73734-07-3 4-(1H-苯并咪唑-2-基氨...

N-乙氧羰基-4-哌啶酮置于titanium(Iv) Isopropylate,氯化铵,三乙胺,Sodium Tetrahydroborate体系中,用 乙醇 作为反应溶剂,化学反应 18.0H,以87%的收率获得产物4-氨基-1-哌啶甲酸乙酯
参考文献:Selective Monoalkylation Of Ammonia: A High Throughput Synthesis Of Primary Amines
标题:Selective Monoalkylation Of Ammonia: A High Throughput Synthesis Of Primary Amines
摘要:初级胺通过与烷基和芳基酮的高度选择性单烷基化反应,使用四异丙氧化钛和硼氢钠获得,产率非常好至优异.
DOI:10.1055/s-1999-2946

专利信息

专利号:US-5877278-A
优先权日:1992-09-24
标题:Synthesis of N-substituted oligomers
发明人：ZUCKERMANN RONALD N; GOFF DANE A; NG SIMON; SPEAR KERRY; SCOTT BARBARA O; SIGMUND AARON C; GOLDSMITH RICHARD A; MARLOWE CHARLES K; PEI YAZHONG; RICHTER LUTZ; SIMON REYNA
权利人:CHIRON CORP
摘要:A solid-phase method for the synthesis of N-substituted oligomers, such as poly (N-substituted glycines) (referred to herein as poly NSGs) is used to obtain oligomers, such as poly NSGs of potential therapeutic interest which poly NSGs can have a wide variety of side-chain substituents. Each N-substituted glycine monomer is assembled from two 'sub-monomers' directly on the solid support. Each cycle of monomer addition consists of two steps: (1) acylation of a secondary amine bound to the support with an acylating agent comprising a leaving group capable of nucleophilic displacement by -NH2, such as a haloacetic acid, and (2) introduction of the side-chain by nucleophilic displacement of the leaving group, such as halogen (as a solid support-bound alpha -haloacetamide) with a sufficient amount of a second sub-monomer comprising an -NH2 group, such as a primary amine, alkoxyamine, semicarbazide, acyl hydrazide, carbazate or the like. Repetition of the two step cycle of acylation and displacement gives the desired oligomers. The efficient synthesis of a wide variety of oligomeric NSGs using automated synthesis technology of the present method makes these oligomers attractive candidates for the generation and rapid screening of diverse peptidomimetic libraries. The oligomers of the invention, such as N-substituted glycines (i.e. poly NSGs) disclosed here provide a new class of peptide-like compounds not found in nature, but which are synthetically accessible and have been shown to possess significant biological activity and proteolytic stability. Combinatorial libraries of cyclic compounds are disclosed wherein the cyclic compounds are comprised of at least one ring structure derived from cyclization of a peptoid backbone. The diversity of product compounds is generated by the sequential addition of substituted submonomers. The combinatorial library includes 10 or more, preferably 100 or more, and more preferably 1,000 or more distinct and different compounds. The library includes each of the product compounds in retrievable and analyzable amounts and preferably includes at least one biologically active compound. Methods of synthesizing the combinatorial libraries and assay devices produced using the libraries are disclosed as is methodology for screening for and obtaining biologically active cyclic organic compounds.

专利号:WO-0140193-A1
优先权日:1999-12-03
标题:Method for the synthesis of pyrazolines
发明人：BOLDI ARMEN M
权利人:CHEMRX ADVANCED TECHNOLOGIES I; BOLDI ARMEN M
摘要:The present invention provides a method for the synthesis of compounds of Formula (I). Also claimed are novel intermediates and their methods of synthesis.

专利号:US-2002103381-A1
优先权日:2000-11-30
标 题 :Method for the synthesis of pyrazolines
发明人：BOLDI ARMEN M
摘要:The present invention provides a method for the synthesis of compounds of Formula I: n n n Also claimed are novel intermediates and their methods of synthesis.

专利号:US-6906046-B2
优先权日:2000-12-22
标题 :Pharmaceutical uses and synthesis of benzobicyclooctanes
发明人：JACKSON RANDY W; DARWISH IHAB; BAUGHMAN TED A; HOWBERT J JEFFRY
权利人:CELLTECH R & D INC
摘要:Benzobicyclooctane compounds, their use in inhibiting cellular events involving TNF-α and IL-8, and in the treatment of inflammation events in general; a combinatorial library of diverse bicyclooctanes and process for their synthesis as a library and as individual compounds.

专利号:US-5010198-A
优先权日:1984-12-03
标题:Intermediates for the synthesis of benzoxazol- and benzothiazolamine derivatives, useful as anti-anoxic agents
发明人：STOKBROEKX RAYMOND A; LUYCKX MARCEL G M; JANSSENS FRANS E
权利人:JANSSEN PHARMACEUTICA NV
摘要:Benzoxazol- and benzothiazolamine derivatives having anti-anoxic properties which compounds are useful in the treatment of anoxia. These compounds are produced from certain benzoxazol- and benzothizolamine intermediates.

专利号:US-11667666-B2
优先权日:2020-01-20
标题 :Methods and compositions for treatment of cancer
发明人：SINGHAL ANUJ
权利人:CFD RES CORPORATION
摘要:In an aspect, the disclosure pertains to inhibitors of ANGPTL4; synthesis methods for making disclosed compounds; pharmaceutical compositions comprising disclosed compounds; methods of treating disorders of uncontrolled cellular proliferation, e.g., a cancer; and methods of treating a disease associated with an ANGPTL4 dysfunction using disclosed compounds and pharmaceutical compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.