CAS: 548-00-5; Ethyl 2,2-Bis(4-Hydroxy-2-Oxochromen-3-yl)Acetate
该化合物其结构特征为乙基酯连接的两组科马林,影响其生物活动和再活性.该化合物在标准条件下相对稳定,但在有湿气或强酸的情况下可能进行水解.安全数据表明,应谨慎处理,因为它可能会引起皮肤和眼刺激.
- ⚠️《化妆品禁用原料目录》
- 英文名称Ethyl 2,2-Bis(4-Hydroxy-2-Oxochromen-3-yl)Acetate
- 中文名称双香豆乙酯
- IUPAC名称2H-1-Benzopyran-3-acetic acid, 4-hydroxy-alpha-(4-hydroxy-2-oxo-2H-1-benzopyran-3-yl)-2-oxo-, ethyl ester (9CI)
- CAS编号548-00-5
- MFCD编号:MFCD00128073
- EINECS号:208-940-5
- FDA UNII编号:08KL644731
- 分子式:C22H16O8分子量:408.36
- 产品CID: 2511998
- 产品分类原料药 → 血液系统用药 → 抗凝血药及抗血小板药
物理性质
- 熔点177-182° and mp 154-157°
- 沸点448.92°C (粗估)
- 闪点238.093 °C
- 密度1.3259 (粗估)
- pKa:pKa 7.5 (Uncertain)
- PSA:127.18
- LogP:3.0056
- 折射率1.4480 (估算)
- 蒸汽压0 mmHg at 25 °C
- 溶解性Chloroform (Slightly), DMSO (Slightly)
- 外观形态白色固体
- 储存条件安瓿瓶, -20°C 冰箱, 在惰性气其中
- 产品应用该化合物是一种用作抗COAGUANT剂的COUMARIN,其行动与WARFARIN相似(从MARTINDALE, THE PURT PHARMACOPOEIA, 30TH ED, P226).
MSDS等安全信息
上下游产品
glyoxylic acid ethyl ester 4-hydroxy[1]benzopyran-2-one合成工艺路线路线简述
📜4-羟基-Alpha-(4-羟基-2-氧代-2H-1-苯并吡喃-3-基)-2-氧代-2H-1-苯并吡喃-3-乙酸,乙醇 反应生成 双香豆乙酯
参考文献:Indruch,M.;Gabrifl,J.;Dostal,M.;Mayer,J.
标题:Indruch,M.;Gabrifl,J.;Dostal,M.;Mayer,J.
海关参考信息
- 2902200000-苯
2909110000-乙醚
2912110000-甲醛
2912120000-乙醛 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-10925977-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
发明人：YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.
专利号:US-10814013-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
专利号:AU-2007308022-A2
优先权日:2006-10-05
标题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
专利号:AU-2007308022-A1
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
专利号:US-2008107598-A1
优先权日:2006-10-05
标 题:Efficient Synthesis of Chelators for Nuclear Imaging and Radiotherapy: Compositions and Applications
专利号:AU-2007308022-B2
优先权日:2006-10-05
标题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Perlík F, Patzelová V. Pharmacokinetics of ethyl biscoumacetate and its metabolite 7-hydroxy ethyl biscoumacetate in healthy volunteers. Int J Clin Pharmacol Ther. 1994 Nov;32(11):622-4. 21(11):3793. doi: 10.3390/ijms21113793.
3: Garrettson LK, Perel JM, Dayton PG. Methylphenidate interaction with both anticonvulsants and ethyl biscoumacetate. JAMA. 1969 Mar 17;207(11):2053-6.
66:487-8. doi: 10.1111/j.1471-0528.1959.tb02065.x. 48(2):119-23. French. 93(1):33-4.
合成参考文献
摘要:Federation Proceedings, Federation of American Societies for Experimental Biology., 10(303), 1951
摘要:RAEVSKAIA GA. [Treatment of myocardial infarct with anticoagulants]. Klin Med (Mosk). 1958 Aug;36(8):54–60.
摘要:OLWIN JH, FRIEDMAN IA. The control of tromexan therapy. Surg Gynecol Obstet. 1954 Jul;99(1):22–8.
摘要:REIST A. [Tromexan in selective prevention of thrombo-embolic diseases in puerperium]. Gynaecologia. 1954 Apr;137(4):214–20.
📝 需求与反馈
尽可能描述清楚需求与问题信息
