CAS: 540-36-3; 1,4-Difluorobenzene

上下游产品

CAS号455-17-4 1-氟-4-(三甲基硅基)苯 | CAS号371-41-5 4-氟苯酚 | CAS号1765-93-1 4-氟苯硼酸 | CAS号371-40-4 4-氟苯胺 | CAS号459-45-0 Benzenediazoniu... | CAS号348-51-6 2-氯氟苯 | CAS号1516885-16-7 4-fluorobenzene... | CAS号460-00-4 对氟溴苯 | CAS号352-33-0 对氯氟苯 | CAS号455-38-9 间氟苯甲酸 | CAS号399-94-0 2,5-二氟溴苯 | CAS号327-51-5 1,4-二溴-2,5-二氟苯 | CAS号462-06-6 氟苯 | CAS号372-18-9 1,3-二氟苯 | CAS号367-11-3 邻二氟苯 | CAS号71-43-2 苯 | CAS号35730-09-7 2,5-二氟苯甲酰氯

(4-氟苯基)-三甲基锡烷置于吡啶,Potassium Fluoride,Copper(II) Bis(Trifluoromethanesulfonate)体系中,用 乙腈 作为反应溶剂,化学反应 18.0H,以35%的收率获得产物1,4-二氟苯
参考文献:[18 F] Kf的铜介导的芳基锡烷的放射性氟化
标题:[18 F] Kf的铜介导的芳基锡烷的放射性氟化
摘要:描述了用[18 F] Kf进行的铜介导的芳基和乙烯基锡烷的亲核放射性氟化反应.该方法快速,使用可商购的试剂,并且与富电子和缺电子的芳烃底物兼容.该方法已应用于人工合成各种临床相关的放射性示踪剂,包括受保护的[18 F] F-苯丙氨酸和[18 F] F-Dopa.另外,已证明[18 F] Mppf的自动合成可提供200+/-20 Mci的临床验证剂量,并具有2400+/-900 Ci / Mmol的高比活度.
DOI:10.1021/acs.Orglett.6B02911

专利信息

专利号:US-2010016607-A1
优先权日:2006-12-11
标题:Process for the Synthesis of Highly Active Binary Metal Fluoride as a Fluorinating Agent for Aromatics
发明人：DOLBIER JR WILLIAM R; JANMANCHI KRISHNA MURTHY
权利人:UNIV FLORIDA
摘要:The subject invention relates to a process for the synthesis of highly active binary metal fluoride system for the fluorination of aromatic compounds. Fluorinated aromatic compounds are valuable synthons for the chemical synthesis of pharmaceutical drugs and novel polymers. Fluorobenzene is used to control carbon content in steel manufacturing, is an intermediate for pharmaceuticals, pesticides and other organic compounds. Fluorobenzene is typically produced by the reaction of aniline and sodium nitrite in the presence of hydrogen fluoride. The present invention relates to a process for the synthesis of highly active binary metal fluoride system consists of copper (II) fluoride and aluminum (III) fluoride for the fluorination of aromatic compounds in gas phase and recycling of the reagent, in situ, using O 2 and HF.

专利号:US-7148356-B2
优先权日:2001-07-13
标题:Process for the catalytic synthesis of biaryls and polymers from aryl compounds
发明人：SMITH III MILTON R; MALECZKA ROBERT E
权利人:UNIV MICHIGAN STATE
摘要:A process for producing organic substituted aromatic or heteroaromatic compounds including biaryl and biheteroaryl compounds in a two-step reaction. In the first step, the aromatic or heteroaromatic compound is borylated in a reaction comprising a borane or diborane reagent (any boron reagent where the boron reagent contains a B—H, B—B or B—Si bond) and an iridium or rhodium catalytic complex. In the second step, a metal catalyst catalyzes the formation of the organic substituted aromatic or heteroaromatic compound from the borylated compound and an electrophile such as an aryl or organic halide, triflate (OSO 2 CF 3 ), or nonaflate (OSO 2 C 4 F 9 ). The steps in the process can be performed in a single reaction vessel or in separate reaction vessels. The present invention also provides a process for synthesis of complex polyphenylenes starting from halogenated aromatic compounds.

专利号:US-7276637-B2
优先权日:2002-08-02
标题:Synthesis of cyclohexanone derivatives
发明人：BRANDS KAREL MARIE JOSEPH; DAVIES ANTONY JOHN; OAKLEY PAUL JOSEPH; SCOTT JEREMY PETER; SHAW DUNCAN EDWARD; TEALL MARTIN RICHARD
权利人:MERCK & CO INC
摘要:A novel process for preparing cyclohexanone derivatives of formula (I) n nis described. The products are useful as gamma secretase inhibitors, or as intermediates in the synthesis of other gamma secretase inhibitors.

专利号:US-2005087449-A1
优先权日:2002-03-04
标题:Electrochemical synthesis of ammonia
发明人：DENVIR ADRIAN; MURPHY OLIVER J; CISAR ALAN; ROBERTSON PRISCILLA; USELTON KYLE
摘要:A method for electrochemical synthesis of ammonia gas comprising providing an electrolyte between an anode and a cathode, providing hydrogen gas to the anode, oxidizing negatively charged nitrogen-containing species present in the electrolyte at the anode to form an adsorbed nitrogen species, and reacting the hydrogen with the adsorbed nitrogen species to form ammonia. Preferably, the hydrogen gas is provided to the anode by passing the hydrogen gas through a porous anode substrate. It is also preferred to produce the negatively charged nitrogen-containing species in the electrolyte by reducing nitrogen gas at the cathode. However, the negatively charged nitrogen-containing species may also be provided by supplying a nitrogen-containing salt, such as lithium nitride, into the molten salt electrolyte mixture in a sufficient amount to provide some or all of the nitrogen consumed in the production of ammonia.

专利号:US-6712950-B2
优先权日:2002-03-04
标 题 :Electrochemical synthesis of ammonia
发明人：DENVIR ADRIAN; MURPHY OLIVER J; CISAR ALAN; ROBERTSON PRISCILLA; USELTON KYLE
权利人:LYNNTECH INC
摘要:A method for electrochemical synthesis of ammonia gas comprising providing an electrolyte between an anode and a cathode, providing hydrogen gas to the anode, oxidizing negatively charged nitrogen-containing species present in the electrolyte at the anode to form an adsorbed nitrogen species, and reacting the hydrogen with the adsorbed nitrogen species to form ammonia. Preferably, the hydrogen gas is provided to the anode by passing the hydrogen gas through a porous anode substrate. It is also preferred to produce the negatively charged nitrogen-containing species in the electrolyte by reducing nitrogen gas at the cathode. However, the negatively charged nitrogen-containing species may also be provided by supplying a nitrogen-containing salt, such as lithium nitride, into the molten salt electrolyte mixture in a sufficient amount to provide some or all of the nitrogen consumed in the production of ammonia.

专利号:US-5349099-A
优先权日:1993-12-13
标题:Process for preparing intermediates for the synthesis of antifungal agents
发明人：KUO SHEN-CHUN; HOU DONALD; ZHAN ZHENG-YUN
权利人:SCHERING CORP
摘要:Disclosed is a process for preparing allylic halides of the formula I ##STR1## wherein X is Cl, Br or I, for use as intermediates in the synthesis of substituted tetrahydrofuran azole anti-fungal agents.