📜二十八烷醇 反应生成 二十八酸 参考文献:Synthesis Of Long-Chain Fatty Acid Derivatives As A Novel Anti-Alzheimer's Agent 标题:Synthesis Of Long-Chain Fatty Acid Derivatives As A Novel Anti-Alzheimer's Agent 摘要:In Order To Develop New Drugs For Alzheimer'S Disease,We Prepared 17 Fatty Acid Derivatives With Different Chain Lengths And Different Numbers And Positions Of Double Bonds By Using Wittig Reaction And Stereospecific Hydrogenation Of Triple Bonds As Key Reactions. Among Them,(4Z,15Z)-octadecadienoic Acid (10) And (23Z,34Z)-Heptatriacontadienoic Acid (16) Showed The Most Potent Neurite Outgrowth Activities On A Beta(25-35)-Treated Rat Cortical Neurons,Which Activities Were Comparable To That Of A Positive Control,Ngf. Both Fatty Acids 10 And 16 Possess Two (Z)-Double Bonds At The N-3 And N-14 Positions,Which Might Be Important For The Neurite Outgrowth Activity. (C) 2013 Elsevier Ltd. All Rights Reserved. DOI:10.1016/j.Bmcl.2013.12.008
专利号:US-9643915-B2 优先权日:2013-03-15 标题:Methods for the synthesis of sphingomyelins and dihydrosphingomyelins 发明人:ONICIU DANIELA CARMEN; HECKHOFF STEFAN; OSWALD BENOIT; REBMANN PETER; PEER ANDREAS; GONZALEZ MIGUEL; SAUTER PATRIK 权利人:CERENIS THERAPEUTICS HOLDING SA 摘要:The present invention includes methods for the synthesis of sphingomyelins and dihydrosphingomyelins. The present invention also includes methods for the synthesis of sphingosines and dihydrosphingosines. The present invention further includes methods for the synthesis of ceramides and dihydroceramides.
专利号:US-9708354-B2 优先权日:2013-03-15 标 题:Methods for the synthesis of sphingomyelins and dihydrosphingomyelins 发明人:ONICIU DANIELA CARMEN; HECKHOFF STEFAN; OSWALD BENOIT; REBMANN PETER; PEER ANDREAS; GONZALEZ MIGUEL; SAUTER PATRIK 权利人:CERENIS THERAPEUTICS HOLDING SA 摘要:The present invention includes methods for the synthesis of sphingomyelins and dihydrosphingomyelins. The present invention also includes methods for the synthesis of sphingosines and dihydrosphingosines. The present invention further includes methods for the synthesis of ceramides and dihydroceramides.
专利号:US-12018313-B2 优先权日:2016-12-28 标题:Methods, apparatuses, and systems for microorganism strain analysis of complex heterogeneous communities with tracer analytics, determination of functional relationships and interactions thereof, and synthesis of microbial ensembles 发明人:EMBREE MALLORY 权利人:NATIVE MICROBIALS INC 摘要:Methods, apparatuses, and systems for microorganism strain analysis of complex heterogeneous communities with tracer analytics, determination of functional relationships and interactions thereof, and synthesis of microbial ensembles, including dosed microbial ensembles and inoculative microbial ensembles, are disclosed.
专利号:US-10604479-B2 优先权日:2013-11-18 标 题:Continuous process for the one-pot synthesis of metal salts and metal complexes 发明人:LEONARDI GIULIANO; GASPERONI GIOVANNI 权利人:VOLARE & CONNECTING LLC; LEONARDI GIULIANO; NOVUS INT INC 摘要:A continuous process is described for the one-pot synthesis of compounds, such as metal salts and metal complexes, as well as optionally for the protection of the compounds thus obtained by coating and/or impregnation with suitable compounds.
专利号:US-11583842-B2 优先权日:2019-07-24 标题 :Zwitterionic catalysts for (trans)esterification: application in fluoroindole-derivatives and biodiesel synthesis 发明人:YEUNG YING-YEUNG; LAM YING-PONG; KE ZHIHAI; WANG XINYAN; TAN FEI; NG WING-HIN; TSE YING-LUNG STEVE 权利人:UNIV HONG KONG CHINESE 摘要:An amide/iminium zwitterion catalyst has a catalyst pocket size that promotes transesterification and dehydrative esterification. The amide/iminium zwitterions are easily prepared by reacting aziridines with aminopyridines. The reaction can be applied a wide variety of esterification processes including the large-scale synthesis of biodiesel. The amide/iminium zwitterions allow the avoidance of strongly basic or acidic condition and avoidance of metal contamination in the products. Reactions are carried out at ambient or only modestly elevated temperatures. The amide/iminium zwitterion catalyst is easily recycled and reactions proceed in high to quantitative yields.
专利号:US-11981938-B2 优先权日:2017-10-05 标 题 :Microorganisms and methods for the fermentation of cannabinoids 发明人:SZAMECZ BELA KRISZTIAN; VARSZEGI SZILVIA; NEMETH ATTILA; SZABO LORAND; KUMAR ABHINAV 权利人:ELESZTO GENETIKA INC 摘要:Disclosed herein are microorganism and methods that can be used for the synthesis of cannabigerolic acid (CBGA) and cannabinoids. The methods disclosed can be used to produce CBGA, Δ9-tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), cannabichromenic acid (CBCA), Δ9-tetrahydrocannabinol (THC), cannabidiol (CBD), cannabichromene (CBC). Enzymes useful for the synthesis of CBGA and cannabinoids, include but are not limited to acyl activating enzyme (AAE1), polyketide synthase (PKS), olivetolic acid cyclase (OAC), prenyltransferase (PT), THCA synthase (THCAS), CBDA synthase (CBDAS), CBCA synthase (CBCAS), HMG-Co reductase (HMG1), and/or farnesyl pyrophosphate synthetase (ERG20). The microorganisms can also have one or more genes disrupted, such as gene that that controls beta oxidation of long chain fatty acids.
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合成参考文献
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