CAS: 4559-96-0; 1-(4-Bromophenyl)-4-Chlorobutan-1-One

上下游产品

bromobenzene 4-Chlorobutanoyl chloride 1-(4-bromophenyl)cyclobutan-1-ol 1,4-bromoiodobenzene b][1,3]oxazine8a-(4-bromo-phenyl)-hexahydro-pyrrolo[2,1-b][1,3]oxazine 1-(4-bromophenyl)-4-(1H-imidazol-1-yl)-1-butanone (S)-1-(4-Bromo-phenyl)-1-cyclopropyl-2-methanesulfinyl-ethanol 3-p-Methylphenyl-3-hydroxy-N-(4'-p-bromophenyl-4'-oxobutyl)quinuclidinium Chloride

1-(4-溴苯基)环丁醇置于manganese(II) Triflate,Lithium Perchlorate,溶剂黄146,Magnesium Chloride体系中,用 乙腈 作为反应溶剂,化学反应 3.5H,以73%的收率获得产物4'-溴-4-氯苯丁酮
参考文献:锰催化的烷氧基自由基对环烷醇的电化学解构氯化反应.
标题:锰催化的烷氧基自由基对环烷醇的电化学解构氯化反应.
摘要:已经开发了锰催化的环烷醇的电化学解构氯化法.这种电化学方法可从醇中获得烷氧基,并具有广泛的底物范围,可将各种环丙醇和环丁醇转化为可合成使用的β-和γ-氯化酮(40个实例).此外,采用循环流电化学和连续在线纯化的组合以克为单位获得产物.
DOI:10.1021/acs.Orglett.9B03652

专利信息

专利号:US-2012302756-A1
优先权日:2010-02-19
标 题 :Process for synthesis of 2-substituted pyrrolidines and piperadines
发明人：LELETI RAJENDER REDDY; LIU YUGANG; PRASHAD MAHAVIR
权利人:LELETI RAJENDER REDDY; LIU YUGANG; PRASHAD MAHAVIR
摘要:The present invention provides a highly efficient, versatile one-step process for asymmetric synthesis of either diastereomer of 2-substituted pyrrolidines from a single starting material with excellent yields and high diastereoselectivety. Also provided is a method for the asymmetric synthesis of both diastereomers of 2-substituted piperidines with good yields and excellent diastereoselectivety. Diasteroselectivity is controlled effectively by choice of reducing agent.

专利号:US-10112955-B2
优先权日:2015-10-29
标题 :Isoindoline, azaisoindoline, dihydroindenone and dihydroazaindenone inhibitors of Mnk1 and Mnk2
发明人：SPRENGELER PAUL A; REICH SIEGFRIED H; ERNST JUSTIN T; WEBBER STEPHEN E; SHAGHAFI MIKE; MURPHY DOUGLAS; TRAN CHINH
权利人:EFFECTOR THERAPEUTICS INC
摘要:The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula I, or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof. n nFor Formula I compounds A 1 , A 2 , A 3 , A 4 , A 5 , W 1 , Y, R 1 , R 2 , R 3 , R 4 , R 5 , R 6a , R 6b , R 7 , R 8 , R 8a , R 8b , R 9 , R 9a , R 9b , and R 10 and subscript “nâ€? are as defined in the specification. The inventive Formula I compounds are inhibitors of Mnk and find utility in any number of therapeutic applications, including but not limited to treatment of inflammation and various cancers.

专利号:WO-2011103263-A2
优先权日:2010-02-19
标题:Process for synthesis of 2-substituted pyrrolidines and piperadines

专利号:EP-2536687-A2
优先权日:2010-02-19
标 题 :Process for synthesis of 2-substituted pyrrolidines and piperadines