CAS: 25931-47-9; 2-Amino-6-(Phenylmethoxycarbonylamino)Hexanoic Acid

上下游产品

2,6-diamin°Caproic acid L-lysine N-(benzyloxycarbonyl)piperidine L-Lysine hydr°ChlorideN6-benzyloxycarbonyl-N2-propionyl-lysineN6-benzyloxycarbonyl-N2-propionyl-lysine N6-benzyloxycarbonyl-N2-butyryl-lysineN6-benzyloxycarbonyl-N2-butyryl-lysine N6-benzyloxycarbonyl-N2-valeryl-lysineN6-benzyloxycarbonyl-N2-valeryl-lysine N6-benzyloxycarbonyl-N2-chloroacetyl-lysineN6-benzyloxycarbonyl-N2-chloroacetyl-lysine

专利信息

专利号:US-9416113-B2
优先权日:2011-02-10
标 题:Formation of N-protected bis-3,6-(4-aminoalkyl)-2,5,diketopiperazine
发明人：FREEMAN JOHN J; STAMPER ADRIENNE; HEITMANN MELISSA
权利人:MANNKIND CORP; MANNKIND CORP
摘要:The disclosed embodiments detail improved methods for the synthesis of diketopiperazines from amino acids. In particular improved methods for the cyclocondensation and purification of N-protected 3,6-(aminoalkyl)-2,5-diketopiperazines from N-protected amino acids. Disclosed embodiments describe methods for the synthesis of 3,6-bis-[N-protected aminoalkyl]-2,5-diketopiperazine comprising heating a mixture of an amino acid in the presence of a catalyst in an organic solvent. The catalyst is selected from the group comprising sulfuric acid, phosphoric acid, p-toluenesulfonic acid, 1-propylphosphonic acid cyclic anhydride, tributyl phosphate, phenyl phosphonic acid and phosphorous pentoxide among others. The solvent is selected from the group comprising: dimethylacetamide, N-methyl-2-pyrrolidone, diglyme, ethyl glyme, proglyme, ethyldiglyme, m-cresol, p-cresol, o-cresol, xylenes, ethylene glycol and phenol among others.

专利号:US-2022243244-A1
优先权日:2019-10-10
标 题 :Compositions and methods for in vivo synthesis of unnatural polypeptides
发明人：ROMESBERG FLOYD E; FISCHER EMIL C; HASHIMOTO KOJI; FELDMAN AARON W; DIEN VIVIAN T; ZHANG YORKE
权利人:SCRIPPS RESEARCH INST
摘要:Disclosed herein are compositions, methods, and kits for a cell incorporating unnatural amino acids into an unnatural polypeptide. Also disclosed herein are compositions, methods, and kits for increasing activity and yield of the unnatural polypeptide synthesized by the cell.

专利号:US-2006183888-A1
优先权日:2004-08-13
标 题:Pyrrolysine synthesis and modification
发明人：CHAN MICHAEL K; KRZYCKI JOSEPH A
权利人:CHAN MICHAEL K; KRZYCKI JOSEPH A
摘要:Synthetic L-pyrrolysine of formula I, and derivatives thereof, chemical methods of preparing these amino acids and derivatives, and methods of derivatizing these amino acids after incorporation into a peptide or protein. n nAlso provided are derivatives and methods of preparing derivatives, including addition of substituents at any substitutable position; modifications to the lysine alkyl chain; modifications of the pyrroline ring. Also provided are methods of adding labels to the pyrrolysine or derivative thereof.

专利号:WO-2021072167-A1
优先权日:2019-10-10
标 题:Compositions and methods for in vivo synthesis of unnatural polypeptides

专利号:CA-3153855-A1
优先权日:2019-10-10
标题:Compositions and methods for in vivo synthesis of unnatural polypeptides

专利号:EP-4041249-A1
优先权日:2019-10-10
标题 :Compositions and methods for in vivo synthesis of unnatural polypeptides