CAS: 25016-01-7; 5-Bromo-2-Anisaldehyde

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CAS号135-02-4 邻甲氧基苯甲醛 | CAS号77-78-1 硫酸二甲酯 | CAS号1761-61-1 5-溴水杨醛 | CAS号74-88-4 碘甲烷 | CAS号612-16-8 2-甲氧基苯甲醇 | CAS号21702-84-1 2,4-二溴苯甲醚 | CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号104-92-7 对溴苯甲醚 | CAS号4885-02-3 1,1-二氯甲醚 | CAS号14804-31-0 4-溴-2-甲基苯甲醚 | CAS号35431-26-6 5-羟基-2-甲氧基苯甲醛 | CAS号37942-01-1 5-溴-2-甲氧基苯酚 | CAS号21962-53-8 5-氰基-2-甲氧基苯甲醛 | CAS号185244-57-9 2-(5-bromo-2-me... | CAS号190270-76-9 2-甲氧基-5-(2-噻吩)苯甲醛 | CAS号185244-58-0 4-bromo-1-metho... | CAS号19652-29-0 1-(5-bromo-2-me... | CAS号213620-52-1 5-bromo-2-metho... | CAS号2199-87-3 6-溴香豆素-3-甲酸 | CAS号81224-16-0 7-溴-4-甲氧基-1H-吲哚

邻甲氧基苯甲醛置于n-溴酞亚胺体系中,用 乙醚 用作溶剂,化学反应 1.0H,以72%的收率获得5-溴-2-甲氧基苯甲醛
参考文献:对溴芳族化合物的区域选择性合成
标题:对溴芳族化合物的区域选择性合成
摘要:取代苯环与 N-溴邻苯二甲酰亚胺在中性条件下反应得到相应的溴代衍生物,优先形成对溴代异构体而不是邻位异构体.简单的后处理程序最大限度地减少了产品的损失,并且收率非常好.
Doi:10.1002/jccs.200500082

专利信息

专利号:EP-1546135-B1
优先权日:2002-07-16
标题:Novel synthesis of irbesartan
发明人：NISNEVICH GENNADY; RUKHMAN IGOR; PERTSIKOV BORIS; KAFTANOV JULIA; DOLITZKY BEN-ZION
权利人:TEVA PHARMA
摘要:Provided is a novel synthesis of irbesartan employing a phase transfer catalyst. Also provided is irbesartan having a fine particle size.

专利号:US-7312340-B2
优先权日:2003-02-05
标 题:Synthesis of 2-butyl-3-(1-trityl-1H-tetrazol-5-YL)biphenyl-4-YL)-1,3-diazaspiro[4,4]- non-ene-4-one
发明人：DOLITZKY BEN-ZION; KAFTANOV JULIA; PERTSIKOV BORIS; RUKHMAN IGOR; NISNEVICH GENNADY
权利人:TEVA PHARMA
摘要:Provided is a novel method of making 2-butyl-3-[[2′(1-trityl-1H-tetrazol-5-yl)biphen-4-yl]methyl]-1,3-diazaspiro[4.4]non-1-ene-4-one, which can be converted to irbesartan. Also provided are methods of making irbesartan.

专利号:US-5175302-A
优先权日:1987-07-13
标 题 :Nucleophilic fluoroalkylation of aldehydes
发明人：STAHLY G PATRICK
权利人:ETHYL CORP
摘要:Aryl difluoromethyl sulfone adds to aldehydes under phase transfer conditions to give novel substituted alcohols of the general formula n n RCH(OH)CF.sub.2 SO.sub.2 Ar (I) n n wherein R is an aryl, cycloaliphatic, sec- or tert-aliphatic, or heterocyclic group and Ar is an aryl group. The substituted alcohols of formula I are of particular utility as intermediates in the synthesis of a variety of useful end products. For example, the products of formula I may be utilized in desulfonylation reactions, oxidation reactions and fluorination reactions.

专利号:US-4999429-A
优先权日:1989-01-09
标 题 :Process for the preparation of α,α,β-1-trifluoro-1-olefinic derivatives
发明人：STAHLY G PATRICK
权利人:ETHYL CORP
摘要:Aryl difluoromethyl sulfone adds to aldehydes under phase transfer conditions to give novel substituted alcohols of the general formula n n RCH(OH)CF.sub.2 SO.sub.2 Ar (I) n n wherein R is an aryl, cycloaliphatic, sec- or tert-aliphatic, or heterocyclic group and Ar is an aryl group. The substituted alcohols of formula I are of particular utility as intermediates in the synthesis of a variety of useful end products. For example, the products of formula I may be utilized in desulfonylation reactions, oxidation reactions and fluorination reactions.

专利号:US-6326498-B1
优先权日:2001-03-13
标 题 :Process for the synthesis of 5-(2-flurophenyl)-1H-tetrazole
发明人：MALLADI PARDHASARADHI; KANTEVARI SRINIVAS; NAIR CHEMBUMKULAM KAMALAKSHYAM
权利人:COUNCIL SCIENT IND RES
摘要:The present invention discloses a process of the preparation of 5-(2-flurophenyl)-1H-tetrazole of the formula 2 by reacting 2-fluoro benzonitrile of the formula 1 n with an inorganic azide and an amine salt in an aromatic solvent, precipitating the product with hydrochloric acid and separating the precipitated product.

专利号:US-7741492-B2
优先权日:2005-02-28
标题:Method for obtaining a pharmaceutically active compound (Irbesartan) and its synthesis intermediate
发明人：HUGUET CLOTET JOAN; DALMASES BARJOAN PERE
权利人:INKE SA
摘要:It is provided a method for obtaining Irbesartan polymorph A, with few synthesis steps, by coupling the intermediate of formula (II) with the compound of formula (III), neutralising one of its alkaline salts in an aqueous medium and recrystallising the crude product obtained. The utilisation of said method obviates protection and deprotection of the tetrazole ring and is therefore of considerable interest for obtaining Irbesartan on a large industrial scale. The invention also refers to the synthesis intermediate of formula (II).