CAS: 23585-49-1; 3-(Hydroxymethyl)Pyrazole

相似化合物

15366-34-4 3920-50-1 5932-27-4

上下游产品

diazomethane diethyl ether propargyl alcohol 4,4-diethoxy-but-2-yn-1-ol 3-(chloromethyl)-1H-pyrazole 1-Amino-1H-pyrazol-3-methanol 3-bromomethylpyrazole 1-(7-(5-(hydroxymethyl)-1H-pyrazol-1-yl)-4-methoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-(5-(pyridin-2-yl)-3,4-dihydroisoquinolin-2(1H)-yl)ethane-1,2-dione

吡唑-3-羧酸甲酯置于lithium Aluminium Tetrahydride体系中,用 四氢呋喃 用作溶剂,化学反应生成3-羟甲基吡唑
参考文献:含吡唑亚基的大双环配体的合成:N,N'-联吡唑基隐窝
标题:含吡唑亚基的大双环配体的合成:N,N'-联吡唑基隐窝
摘要:吡唑基穴状配体[bpz.Bpz.Bpz](1)和[2.2.Bpz](2)是通过1,1'-联吡唑衍生物一步一步,非高稀释度的大环合成反应制得的.同样,描述了具有吡唑结构的三脚架配体(7)-(9).
Doi:10.1039/c39850001765

专利信息

专利号:US-2005085555-A1
优先权日:1997-08-21
标 题:Composition, synthesis and therapeutic applications of polyamines
发明人：MURPHY MICHAEL A; MALACHOWSKI MITCHELL R
摘要:This invention relates to a process of synthesis and composition of open chain (ring), closed ring, linear branched and or substituted polyamines, polyamine derived tyrosine phosphatase inhibitors and PPAR partial agonists/partial antagonists via a series of substitution reactions and optimizing the bioavailability and biological activities of the compounds. Polyamines prevent the toxicty of neutoxins and diabetogenic toxins including paraquat, methyphenyl pyridine radical, rotenone, diazoxide, streptozotocin and alloxan. These polyamines can be to treat neurological, cardiovascular, endocrine acquired and inherited mitochondrial DNA damage diseases and other disorders in mammalian subjects, and more specifically to the therapy of Parkinson's disease, Alzheimer's disease, Lou Gehrig's disease, Binswanger's disease, Olivopontine Cerebellar Degeneration, Lewy Body disease, Diabetes, Stroke, Atherosclerosis, Myocardial Ischemia, Cardiomyopathy, Nephropathy, Ischemia, Glaucoma, Presbycussis, Cancer, Osteoporosis, Rheumatoid Arthritis, Inflammatory Bowel Disease, Multiple Sclerosis and as Antidotes to Toxin Exposure.

专利号:US-2014057877-A1
优先权日:2002-12-18
标题:Therapeutic polyamine compositions and their synthesis
发明人：MURPHY MICHAEL A; MALACHOWSKI MITCHELL R
权利人:MURPHY MICHAEL A; MALACHOWSKI MITCHELL R
摘要:This invention relates to a process of synthesis and composition of open chain (ring), closed ring, linear branched and or substituted polyamines, polyamine derived tyrosine phosphatase inhibitors and PPAR partial agonists/partial antagonists via a series of substitution reactions and optimizing the bioavailability and biological activities of the compounds. Polyamines prevent the toxicity of neurotoxins and diabetogenic toxins including paraquat, methyphenyl pyridine radical, rotenone, diazoxide, streptozotocin and alloxan. These polyamines can be utilized to treat neurological, cardiovascular, endocrine acquired and inherited mitochondrial DNA damage diseases and other disorders in mammalian subjects, and more specifically to the therapy of Parkinson's disease, Alzheimer's disease, Lou Gehrig's disease, Binswanger's disease, Olivopontine Cerebellar Degeneration, Lewy Body disease, Diabetes, Stroke, Atherosclerosis, Myocardial Ischemia, Cardiomyopathy, Nephropathy, Ischemia, Glaucoma, Presbycussis, Cancer, Osteoporosis, Rheumatoid Arthritis, Inflammatory Bowel Disease, Multiple Sclerosis and as Antidotes to Toxin Exposure.

专利号:US-10874646-B2
优先权日:2015-10-16
标 题 :Epothilone analogs, methods of synthesis, methods of treatment, and drug conjugates thereof
发明人：NICOLAOU KYRIACOS C; RHOADES DEREK; WANG YANPING; TOTOKOTSOPOULOS SOTIRIOS
权利人:UNIV RICE WILLIAM M
摘要:In one aspect, the present disclosure provides epothilone analogs of the formula (I) wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein. Additionally, drug conjugates with cell targeting moieties of the compounds are also provided.

专利号:US-9314021-B2
优先权日:2004-11-03
标题 :Formulations containing insect repellent compounds
发明人：SCIALDONE MARK A
权利人:DU PONT
摘要:Dihydronepetalactone, a minor natural constituent of the essential oil of catmints ( Nepeta spp.) such as Nepeta cataria , has been identified as an effective insect repellent compound. Synthesis of dihydronepetalactone may be achieved by hydrogenation of nepetalactone, the major constituent of catmint essential oils. This compound, and compositions thereof, which also has fragrance properties, may be used commercially for its insect repellent properties.

专利号:EP-0302633-A2
优先权日:1987-08-07
标 题:Beta-lactam compound, process for preparing the same, intermediate for synthesis of the same and medicinal composition for bacterially infectious disease therapy containing the same

专利号:EP-3371176-A1
优先权日:2015-10-16
标 题:Epothilone analogs, methods of synthesis, methods of treatment, and drug conjugates thereof