CAS: 194658-14-5; (4-Methoxypyridin-2-yl)Methanamine
该化合物是一个有机化合物,其特征是其环结构,以及一个有矿功能的组.该化合物的特性是附于环第四位置的甲氧基组(-OCH3),该组影响其化学反应性和溶性.该组的颜色一般不光亮,不光黄色液体或固体,视其形态和纯度而定.该矿群的存在表明它可以参与氢结合,使其有可能溶于极地溶剂中.该组可能展示生物活动,使其在制药研究中引起兴趣.其特性,如熔点,沸点和特定反应性,可根据处理该环的纯度和具体条件而有所不同.在处理和储存时,应参考安全数据,如任何化学物质,以确保采取适当的预防措施.
- 英文名称(4-Methoxypyridin-2-yl)Methanamine
- 中文名称4-甲氧基-2-甲氨基吡啶
- IUPAC名称(4-methoxypyridin-2-yl)methanamine
- 其它别名(4-甲氧基吡啶-2-基)甲胺; 2-Pyridinemethanamine,4-Methoxy-(9Ci)
- CAS编号194658-14-5
- MFCD编号:MFCD11111886
- EINECS号:824-269-6
- 分子式:C7H10N2O分子量:138.17
- 产品CID: 989016
- 产品分类有机原料→分子砌块→芳杂环类化合物→吡啶类化合物
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1344046-06-5 1956342-04-3 90151-10-3物理性质
MSDS等安全信息
欧盟法规
C&L通报上下游产品
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合成工艺路线路线简述
📜4-甲氧基吡啶-2-醛置于盐酸羟胺,三氟乙酸,Sodium Hydroxide,锌体系中,用 乙醇,水 用作溶剂,化学反应 5.5H,反应生成4-甲氧基-2-甲氨基吡啶
参考文献:Optimization Of Pentadentate Bispidines As Bifunctional Chelators For64Cu Positron Emission Tomography (Pet)
标题:Optimization Of Pentadentate Bispidines As Bifunctional Chelators For64Cu Positron Emission Tomography (Pet)
摘要:Pentadentate Bispidine Ligands (3,7-Diazabicyclo[3.3.1]Nonanes) Are Optimized For Maximum Complex Stability And Facile Functionalization With Respect To Their Coupling To Biological Vector Molecules And/or Fluorescence Markers For Pet (Positron Emission Tomography) And Multimodal Imaging (I.E.,Pet And Optical Imaging). The Pentadentate Ligand With Two Tertiary Amine Donors,Two P-Methoxy Substituted Pyridines,And One Unsubsituted Pyridine Group Is Shown To Best Fulfill Important Conditions For Pet Applications,I.E.,Fast Complexation With Cu-Ii And High In Vivo Stability,And This Was Predicted From The Solution Chemistry,In Particular The Cu-Ii/i Redox Potentials. Also,Solvent Partition Experiments To Model The Lipophilicity Of The Cu-Ii Complexes Indicate That The Bis P-Methoxy Substituted Ligand Leads To Cationic Complexes With An Appreciable Lipophilicity. This Is Supported By The Biodistribution Experiments That Show That The Complex With The P-Methoxy Substituted Ligand Is Excreted Very Quickly And Primarily Via The Renal Route And Therefore Is Ideally Suited For The Development Of Pet Tracers With Ligands Of This Type Coupled To Biomolecules.
Doi:10.1021/ic4008685
海关参考信息
- 2905110000-甲醇
2933310010-吡啶
2909199090-其他醚及其衍生物
2939800000-其他生物碱 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-2011124634-A1
优先权日:2008-05-13
标 题:Bioactive compounds for treatment of cancer and neurodegenerative diseases
发明人：SUN CONNIE L; LI XIAOYUAN
权利人:PONIARD PHARMACEUTICALS INC
摘要:The invention provides bioactive compounds for the treatment of various malconditions such as cancer and neurodegenerative diseases including Alzheimer's disease. The chemical compounds as disclosed herein are found to show bioactivity in bioassays related to these conditions. Pharmaceutical compositions, combinations and methods of synthesis are provided, as are methods of using the compound, compositions and combinations in the treatment of the diseases.
