CAS: 1875-48-5; 2-Aminoisoindoline-1,3-Dione

该化合物是一种有机化合物,其结构特征是具有与一个伴有氨基氨基组的相正硫化物,该化合物一般是晶状固体,以其在各个领域的潜在用途而著称,包括有机合成和材料科学.N-Aminophothalimide展示了有机溶剂中中中溶性以及在标准条件下稳定性等特性;它可以参与各种化学反应,包括核嗜好替代和循环过程,使它成为合成复杂分子的多功能中间体.此外,它可能表现出荧光特性,可以用于染色应用或作为生物化学实验中的荧光探针.在处理该化合物时,应当考虑到安全因素,因为如果吸入或摄入,可能会对健康造成危害.总的来说,N-Aminophothalimide是有机化学领域的宝贵化合物,其独特的化学特性产生多种应用.

结构式图片

物理性质

MSDS等安全信息

欧盟法规

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上下游产品

-1H-isoindole-1,3(2H)-dione2-(1H-Imidazol-1-yl)°Ctyl-1H-isoindole-1,3(2H)-dione phthalic anhydride phthalimide ethanolN-phthalimido-phthalamic acidN-phthalimido-phthalamic acid trans-cinnamylidenamino-isoindoline-1,3-dione2-trans-cinnamylidenamino-isoindoline-1,3-dione 2-[5-(4-nitro-phenoxy)-pentylamino]-isoindoline-1,3-dione [2,2'-biisoindoline]-1,1',3,3'-tetraone

合成工艺路线路线简述

  • 219611-74-2 = 1875-48-5 + 90564-77-5
    反应条件:1.1 Reagents: Hydrazine Hydrate (1:1) Solvents: Ethanol,Water; Rt; 5 H,Reflux; Overnight,4 °C
    标题:Synthesis And Cytotoxic Activity Of (4-Substituted-Benzylidene)-(3-Phenyl-1,2,4-Oxadiazol-5-Yl)Methylamines
    作者:Kucukoglu,K.; Tugrak,M.; Demirtas,A.; Sakagami,H.; Gul,H. I.
    参考文献:Pharmaceutical Chemistry Journal 日期:2016 卷标:50(4) 页码:234-238
1,4-二氧六环置于palladium On Activated Charcoal体系中,用 溶剂黄146 用作溶剂,化学反应生成氨基邻苯二甲胺
参考文献:Method Of Inhibiting Binding Of Nerve Growth Factor To P75 Ntr Receptor
标题:Method Of Inhibiting Binding Of Nerve Growth Factor To P75 Ntr Receptor
摘要:本发明涉及抑制神经生长因子与p75Ntr共同神经营养因子受体结合的组合物和使用方法.在一个实施例中,抑制神经生长因子与p75Ntr结合的化合物,特别是当与神经生长因子结合时,至少包括以下两种:(1)第一个电负原子或功能基团,位于与神经生长因子的lys34相互作用的位置;(2)第二个电负原子或功能基团,位于与神经生长因子的lys95相互作用的位置;(3)第三个电负原子或功能基团,位于与神经生长因子的lys88相互作用的位置;(4)第四个电负原子或功能基团,位于与神经生长因子的lys32相互作用的位置;以及(5)与神经生长因子的ile31,Phe101和phe86形成的疏水区域相互作用的疏水基团.

海关参考信息

专利信息


专利号:WO-9616071-A1
优先权日:1994-11-21
标题:PROCESSES FOR THE SYNTHESIS OF 3'-SUBSTITUTED LEWISx COMPOUNDS
发明人：SRIVASTAVA OM; IPPOLITO ROBERT; SRIVASTAVA GEETA; SZWEDA ROMAN; OHUCHI TOSHIO
权利人:GLYCOMED INC; SRIVASTAVA OM; IPPOLITO ROBERT; SRIVASTAVA GEETA; SZWEDA ROMAN; OHUCHI TOSHIO
摘要:Disclosed are processes for the chemical synthesis of 3'-substituted Lewis-OR compounds where R is an aglycon of at least one carbon atom. One particular compound prepared by the processes of this invention is 8-methoxycarbonyl-octyl-2-acetamido-3-O-( alpha -L-fucopyranosyl)-4-O-[3-O-sulfo- beta -D-galactopyranosyl]-2-deoxy- beta -D-glucopyranoside.

专利号:US-2020354404-A1
优先权日:2019-05-09
标 题 :Peptidomimetic agents, synthesis and uses thereof
发明人：AL-ABED YOUSEF
权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
摘要:Compounds for use in synthesis of peptidomimetic agents; synthesis of peptidomimetic agents; peptidomimetic diagnostic and therapeutic agents; and uses of the compounds and peptidomimetic agents in drug discovery, diagnosis, prevention and treatment of diseases are described.

专利号:US-8604241-B2
优先权日:2009-01-29
标题:Method for synthesis of (1S, 2R)-milnacipran
发明人：NICOLAS MARC; HELLIER PAUL; DIARD CATHERINE; SUBRA LAURENT
权利人:NICOLAS MARC; HELLIER PAUL; DIARD CATHERINE; SUBRA LAURENT; PF MEDICAMENT
摘要:The present invention relates to a method for synthesizing a pharmaceutically acceptable acid addition salt of (1S, 2R)-milnacipran comprising the following successive steps: (a) reaction of phenylacetonitrile and of (R)-epichlorhydrin in the presence of a base containing an alkaline metal, followed by a basic treatment, and then by an acid treatment in order to obtain a lactone; (b) reaction of said lactone with MNEt 2 , wherein M represents an alkaline metal, or with NHEt 2 in the presence of a Lewis acid-amine complex, in order to obtain an amide-alcohol; (c) reaction of said amide-alcohol with thionyl chloride in order to obtain a chlorinated amide; (d) reaction of said chlorinated amide with a phthalimide salt in order to obtain a phthalimide derivative; (e) hydrolysis of the phthalimide group of said phthalimide derivative in order to obtain (1S, 2R)-milnacipran, and (f) salification of (1S, 2R)-milnacipran in a suitable solvent system in the presence of a pharmaceutically acceptable acid.

专利号:US-2006111438-A1
优先权日:2004-10-21
标 题:Asymmetric synthesis of substituted dihydrobenzofurans
发明人：GONTCHAROV ALEXANDER V; KHAFIZOVA GULNAZ; POTOSKI JOHN R; YU QING; SHAW CHIA-CHENG; STACK GARY P; ZHOU DAHUI
权利人:WYETH CORP
摘要:The present invention concerns production of a compound of the formula n n nor a pharmaceutically acceptable salt thereof by a process which utilizes the cyclization of a compound of the formula: n n nwhere Ar, Y, R 1 , R y , R 2 , and m are as defined herein.

专利号:US-2005080260-A1
优先权日:2003-04-22
标 题 :Preparation of prodrugs for selective drug delivery
发明人：MILLS RANDELL L; WU GUO-ZHANG
摘要:Synthesis of a chemical compound having the formula A-B-C that may serve for applications such as drug delivery where A is a chemiluminescent, moiety, B is a photochromic moiety, and C is a biologically active moiety where A-B-C may serve as a prodrug. Novel synthetic methods of the present invention to form the prodrug comprised the steps of (1) forming a benzophenone, (2) forming a diaryl ethylene, (3) attaching a phthalimide moiety to at least one of the aryl groups of the ethylene to form a phthalimide-ethylene conjugate, (4) condensing two ethylene-phthalimide conjugates to form a phthalimide-pentadiene conjugate, (5) converting the phthalimide to the phthalhydrazide by reaction with hydrazine to form a carrier compound according to the present invention, and (6) reacting the carrier compound with an nucleophilic moiety of the drug to form the corresponding prodrug. Alternatively the carrier can be prepared by using the halo-substituted diaryl ethylene to make the corresponding cationic leuco dye-like compound with known methods. The cationic compound then is protected by reacting with a nucleophile and coupled with the aminophathalimide by palladium-catalyzed amination to form the protected phthalimide-pentadiene conjugate. The latter is refluxed with hydrazine to convert its phthalimide to the phthalhydrazide and acidified to give the carrier. An additional aspect of the present invention relates to the use of these compounds as antiviral agents for the treatment of viral infections such as HIV and as anticancer agents for the treatment of cancers such as bowel, lung, and breast cancer.

专利号:US-8461298-B2
优先权日:2004-11-01
标 题:Compositions and methods for modification of biomolecules
发明人：BERTOZZI CAROLYN R; AGARD NICHOLAS J; PRESCHER JENNIFER A; BASKIN JEREMY MICHAEL
权利人:BERTOZZI CAROLYN R; AGARD NICHOLAS J; PRESCHER JENNIFER A; BASKIN JEREMY MICHAEL; UNIV CALIFORNIA
摘要:The present invention provides modified cycloalkyne compounds; and method of use of such compounds in modifying biomolecules. The present invention features a cycloaddition reaction that can be carried out under physiological conditions. In general, the invention involves reacting a modified cycloalkyne with an azide moiety on a target biomolecule, generating a covalently modified biomolecule. The selectivity of the reaction and its compatibility with aqueous environments provide for its application in vivo (e.g., on the cell surface or intracellularly) and in vitro (e.g., synthesis of peptides and other polymers, production of modified (e.g., labeled) amino acids).

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主要参考文献

[参考文献]: Kung-Shou Yang, Et Al. Enantioselective Aziridination Of Alkenes With N-Aminophthalimide In The Presence Of Lead Tetraacetate-Mediated Chiral Ligand. Org Lett. 2002 Apr 4;4(7):1107-9.

合成参考文献


摘要:Aggarwal, P.; Bebbington, M. W. P., Science of Synthesis Knowledge Updates, (2012) 2, 378.
摘要:Muchalski, H.; Johnston, J. N., Science of Synthesis: Stereoselective Synthesis, (2011) 1, 159.
摘要:Muchalski, H.; Johnston, J. N., Science of Synthesis: Stereoselective Synthesis, (2011) 1, 155.
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