CAS: 168828-84-0; (R)-[n-3-(3-Fluoro-4-Morpholinylphenyl)-2-Oxo-5-Oxazolidinyl]Methyl Azide

上下游产品

CAS号174649-09-3 (R)-N-[3-(3-氟-(... | CAS号677726-40-8 (R)-5-azidometh... | CAS号1250999-09-7 4-(2-fluoro-4-i... | CAS号168828-83-9 (R)-[N-3-(3-flu... | CAS号168828-82-8 (5R)-3-[3-氟-4-(... | CAS号369-34-6 3,4-二氟硝基苯 | CAS号2689-39-6 4-(2-氟-4-硝基苯基)吗啉 | CAS号513068-89-8 4-(2-氟-4-溴苯基)吗啉 | CAS号1223581-08-5 (R)-N-(3-fluoro... | CAS号168828-90-8 (S)-5-(氨基甲基)-3-... | CAS号165800-03-3 利奈唑胺

2-氟苯酚置于bis(1,5-Cyclooctadiene)Nickel (0),Trans-1,2-Diaminocyclohexane,Copper(L) Chloride,1,3-双-(2,6-二异丙基苯基)咪唑鎓氯化物 N-碘代丁二酰亚胺,Sodium Hydride,Potassium Carbonate,三氟乙酸,Sodium T-Butanolate体系中,用 1,4-二氧六环,乙二醇二甲醚,Mineral Oil 用作溶剂,化学反应 47.0H,反应生成吗啉恶酮相关物质a
参考文献: Amination Of Aryl Alcohol Derivatives[fr] Amination De Dérivés D'Alcool Arylique
标题: Amination Of Aryl Alcohol Derivatives[fr] Amination De Dérivés D'Alcool Arylique

专利信息

专利号:US-9567307-B2
优先权日:2011-01-07
标题:Amination of aryl alcohol derivatives
发明人：GARG NEIL K; RAMGREN STEPHEN D; SILBERSTEIN AMANDA L; QUASDORF KYLE W
权利人:GARG NEIL K; RAMGREN STEPHEN D; SILBERSTEIN AMANDA L; QUASDORF KYLE W; UNIV CALIFORNIA
摘要:Embodiments of the invention provide methods and materials for chemical cross-coupling reactions that utilize aryl alcohol derivatives as cross-coupling partners. Embodiments of the invention include methods for the amination of aryl sulfamates and carbamates, which are attractive cross-coupling partners, particularly for use in multistep synthesis. Illustrative embodiments include versatile means to use simple derivatives of phenol as precursors to polysubstituted aryl amines, as exemplified by a concise synthesis of the antibacterial drug linezolid.