CAS: 160709-02-4; ((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)Methyl)-5-(2,4-Difluorophenyl)Tetrahydrofuran-3-yl)Methanol

相似化合物

149809-43-8 149882-18-8 149882-18-8

上下游产品

CAS号149809-43-8 泊沙康唑主环

[(2R,4R)-4-(2,4-Difluorophenyl)-4-Hydroxy-2-(Hydroxymethyl)-5-(1,2,4-Triazol-1-yl)Pentyl] Acetate置于4-二甲氨基吡啶,氢氧化钾,Sodium Hydride,对甲苯磺酸体系中,用 四氢呋喃,甲醇,二氯甲烷,水 用作溶剂,化学反应 61.0H,反应生成2,5-脱水-1,3,4-三脱氧-2-C-(2,4-二氟苯基)-4-(羟甲基)-1-(1H-1,2,4-三唑-1-基)-D-苏式-戊糖醇
参考文献:具有远程手性功能的ppl催化的2-取代的前手性1,3-二醇的酶促不对称化:对sch 45012 Eutomer的合成的改进
标题:具有远程手性功能的ppl催化的2-取代的前手性1,3-二醇的酶促不对称化:对sch 45012 Eutomer的合成的改进
摘要:猪胰脂肪酶(ppl)催化已用于建立顺式(四氢呋喃基甲基)甲苯磺酸4的两个立体中心.除了对2的手性1,3-二醇片段的羟基进行酶促区分外,外消旋二醇10的成功酶解提供了通往重要前体1的另一条途径.
Doi:10.1016/0040-4039(94)88071-9

专利信息

专利号:WO-2019077627-A1
优先权日:2017-10-16
标题:PROCESS FOR PRODUCING POSACONAZOLE
发明人：NANDEPU Venkateswara Rao; BIJJULA VENKATA KRISHNA REDDY; BATHINA Satyanarayana
权利人:METROCHEM API PVT LTD
摘要:The present invention relates to an improved process for the manufacture of Posaconazole, an antifungal agent belonging to the category of triazole compound substituted tetrahydrofuran. The present invention further relates to the preparation of Formula A and Formula B, key intermediates in the preparation of Posaconazole. The invention also relates to novel intermediates that are useful in the synthesis of Posaconazole.

专利号:EP-0770075-B1
优先权日:1994-07-08
标 题 :Process for the preparation of chiral intermediates useful for the synthesis of antifungal agents

专利号:JP-3856822-B2
优先权日:1994-07-08
标 题:Process for the preparation of chiral intermediates useful for the synthesis of antifungal agents

专利号:CN-119591585-A
优先权日:2024-12-20
标题:Synthesis method of posaconazole key intermediate