CAS: 159326-68-8; Pyrrolo[2,1-F][1,2,4]Triazin-4-Amine

上下游产品

CAS号937046-98-5 4-氨基-7-溴吡咯并[2,1... | CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号1003-29-8 吡咯-2-甲醛 | CAS号159326-66-6 1-氨基-1H-吡咯-2-甲腈 | CAS号937046-98-5 4-氨基-7-溴吡咯并[2,1... | CAS号937047-47-7 5-溴吡咯并[1,2-f][1...

N'-Cyano-N-Pyrrol-1-Ylmethanimidamide置于三氟化硼乙醚,三(五氟苯基)硼烷体系中,用 1,2-二氯乙烷 用作溶剂,化学反应 7.0H,以52.7%的收率获得吡咯并[2,1-F][1,2,4]三嗪-4-胺
参考文献:一种4-氨基吡咯并[2,1-F][1,2,4]三嗪的制备方法
标题:一种4-氨基吡咯并[2,1-F][1,2,4]三嗪的制备方法
摘要:本发明公开了一种4‑氨基吡咯并[2,1‑f][1,2,4]三嗪的制备方法,属于药物合成技术领域.以2,5‑二甲氧基四氢呋喃为原料,与甲酰肼反应得到甲酰氨基吡咯,随后与氰胺和亲核试剂在极性溶剂中反应,通过简单后处理,在催化剂作用下关环得到4‑氨基吡咯并[2,1‑f][1,2,4]三嗪.本发明采用市场上易得原料,整个工艺操作简便,通过对现有文献方法进行改进,两步收率有所提高,有利于发展成符合工业化的合成路线.

专利信息

专利号:US-2025115610-A1
优先权日:2021-08-03
标 题:Process for the catalytic glycosylation of arenes
发明人：LIST BENJAMIN; OBRADORS CARLA; MITSCHKE BENJAMIN; AUKLAND MILES
权利人:STUDIENGESELLSCHAFT KOHLE GGMBH
摘要:The present invention refers to a process for the catalytic glycosylation of arenes which allows, amongst others, the expeditious synthesis of the nucleoside analogue GS-441524 of the antiviral prodrug remdesivir.

专利号:WO-2024193457-A1
优先权日:2023-03-20
标题:Preparation method of pyrrolotriazine compound
发明人：ZHENG CHENGUANG; GUO SONGJING; ZHAO REN; PAN RUI; WANG TAO; TANG PINGSHENG; JIN YEHUA; ZHU WEI; MENG YANHUA
权利人:ZHEJIANG HUAHAI PHARM CO LTD
摘要:The present invention belongs to the field of drug synthesis, and more specifically relates to a preparation method of a pyrrolotriazine compound, specifically comprising: firstly reacting compound 2 with NaH and TMSCl to protect the amino group, and then reacting with compound 3 under the action of n-butyl lithium to obtain compound 4; compound 2 can be obtained by reacting compound 1 with a bromination reagent, and compound 1 can be recovered. The method of the present invention is simple to operate, low in cost, and more conducive to industrial production.

专利号:US-9701682-B2
优先权日:2013-11-11
标题:Pyrrolo[1,2-f][1,2,4]triazines useful for treating respiratory syncitial virus infections
发明人：CLARKE MICHAEL O'NEIL HANRAHAN; DOERFFLER EDWARD; MACKMAN RICHARD L; SIEGEL DUSTIN
权利人:GILEAD SCIENCES INC
摘要:Provided herein are formulations, methods and substituted tetrahydrofuranyl-pyrrolo[1,2-f][1,2,4]triazine-4-amine compounds of Formula (I) for treating Pneumovirinae virus infections, including respiratory syncytial virus infections, as well as methods and intermediates for synthesis of tetrahydrofuranyl-pyrrolo[1,2-f][1,2,4]triazine-4-amine compounds.

专利号:CN-113336758-B
优先权日:2020-03-03
标 题:A Novel Synthesis of Compound 7-iodopyrrolo[2,1-f][1,2,4]triazin-4-amine

专利号:CN-113336758-A
优先权日:2020-03-03
标 题:A Novel Synthesis of Compound 7-iodopyrrolo[2,1-f][1,2,4]triazin-4-amine

专利号:WO-2024245115-A1
优先权日:2023-05-31
标 题:Preparation method for pyrrolotriazine compound
发明人：GUO SONGJING; TU GUOLIANG; JIN YEHUA; ZHU WEI; MENG YANHUA
权利人:LINHAI HUANAN CHEMICAL CO LTD; ZHEJIANG HUAHAI PHARM CO LTD
摘要:The present invention relates to the technical field of drug synthesis. A first aspect of the present invention provides a preparation method for a monochloramine organic solution. Another aspect of the present invention provides a use of the preparation method in amination reaction or in preparation of compound 4. The other aspect of the present invention provides a preparation method for compound 4. The present invention also provides preparation methods for compounds 2 and 3. The present invention has a short entire process route, low costs, less generation of three wastes, simple post-treatment, high yield and excellent product quality, and is suitable for industrial production.