CAS: 142-18-7; 2,3-Dihydroxypropyl Dodecanoate

该化合物是一种天然衍生的化合物,具有很强的抗微生物特性,其独特的行动机制干扰细菌细胞膜,使之成为一种有效对抗各种微生物的药剂. 此外,单劳林已被证明具有免疫细胞效应,并有可能用于皮肤护理和伤口愈合.

结构式图片

欧盟法规

REACH注册ECHA物质ECHA物质C&L通报REACH预注册

上下游产品

Sodium laurate 3-mon°Chloro-1,2-propanediol potassium laurate allyl dodecanoatelauric acid glycerol

合成工艺路线路线简述

    烯丙基月桂酸酯置于cethyltrimethylammonium Permanganate体系中,用 二氯甲烷 用作溶剂,化学反应 5.0H,以80%的收率获得甘油单月桂酸酯
    参考文献:Gangadhar,A.; Subbarao,R.; Lakshminarayana,G.,Synthetic Communications,1989,Vol. 19,# 13-14,P. 2505-2514
    标题:Gangadhar,A.; Subbarao,R.; Lakshminarayana,G.,Synthetic Communications,1989,Vol. 19,# 13-14,P. 2505-2514

    海关参考信息

    专利信息


    专利号:US-2003050305-A1
    优先权日:2000-05-22
    标题:Thromboxane inhibitors, compositions and methods of use
    发明人:TEJADA INIGO SAENZ DE
    摘要:The present invention describes methods for treating or preventing sexual dysfunctions in males and females, and for enhancing sexual responses in males and females by administering a therapeutically effective amount of at least one thromboxane inhibitor, and, optionally, at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase, and/or at least one vasoactive agent. The male or female may preferably be diabetic. The present invention also provides novel compositions comprising at least one thromboxane inhibitor, and, at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase, and, optionally, at least one therapeutic agent, such as, vasoactive agents, nonsteroidal antiinflanmmatory compounds (NSAIDs), selective cyclooxygenase-2 (COX-2) inhibitors, anticoagulants, angiotensin converting enzymes (ACE) inhibitors, angiotensin II receptor antagonists, renin inhibitors, and mixtures thereof. The present invention also provides methods for treating or preventing ischemic heart disorders, myocardial infarction, angina pectoris, stroke, migraine, cerebral hemorrhage, cardiac fatalities, transient ischaemic attacks, complications following organ transplants, coronary artery bypasses, angioplasty, endarterectomy, atherosclerosis, pulmonary embolism, bronchial asthma, bronchitis, pneumonia, circulatory shock of various organs, nephritis, graft rejection, cancerous metastases, pregnancy-induced hypertension, preeclampsia, eclampsia, thrombotic and thromboembolic disorders, intrauterine growth, gastrointestinal disorders, renal diseases and disorders, disorders resulting from elevated uric acid levels and dysmenorrhea, and for inhibiting platelet aggregation or platelet adhesion or relaxing smooth muscles.

    专利号:WO-2024130393-A1
    优先权日:2022-12-21
    标 题 :Nanoparticle and method of synthesis thereof
    发明人:MOSKOVCHENKO SVITLANA
    权利人:MOSKOVCHENKO SVITLANA
    摘要:The present technology relates to nanoparticles, compositions comprising said nanoparticles, and methods of synthesis of said nanoparticles; wherein the nanoparticles comprise a metal nanoparticle core, a first coating of amphiphilic molecules, and a second coating of essential oil, essential oil primary constituent, or both, which combine the antimicrobial properties of metal nanoparticles, amphiphilic molecules, and essential oil or essential oil primary constituents.

    专利号:US-9018371-B2
    优先权日:2007-03-07
    标 题 :Adenosine derivatives, method for the synthesis thereof, and the pharmaceutical compositions for the prevention and treatment of the inflammatory diseases containing the same as an active ingredient
    发明人:JEONG LAK SHIN; KIM HEA OK; JACOBSON KENNETH A; CHOE SEUNG AH
    权利人:JEONG LAK SHIN; KIM HEA OK; JACOBSON KENNETH A; CHOE SEUNG AH; FM THERAPEUTICS CO LTD; US OF AMERICA AS REPRESENTED BY THE SECRETARY DEPT OF HEALTH AND HUMAN SERVICES THE OFFICE OF TECHNO
    摘要:Disclosed are adenosine derivatives, methods for the synthesis thereof, and pharmaceutical compositions for the prevention and treatment of inflammatory diseases, comprising the same as an active ingredient. The adenosine derivatives have high binding affinity and selectivity for adenosine receptors, especially for A 3 adenosine receptors and act as A 3 adenosine receptor antagonists, and exhibit anti-inflammatory activity. Thus, the adenosine derivatives are useful in the prevention and treatment of inflammatory diseases.

    专利号:US-7238814-B2
    优先权日:2000-05-09
    标题:Compositions of S-nitrosothiols and methods of use
    发明人:MAREK PRZEMYSLAW A; TROCHA ANDZREJ M; LIN CHIA-EN; RANATUNGE RAMANI R; RICHARDSON STEWART K
    权利人:NITROMED INC
    摘要:The invention describes compositions and kits comprising 4-aza-4-(2-methyl-2-sulfanylpropyl) tricyclo(5.2.1.0<2,6>)dec-8-ene-3,5-dione; 4-aza-4-(2-methyl-2-(nitrosothio)propyl) tricyclo(5.2.1.0<2,6>)dec-8-ene-3,5-dione; 4-{1-methyl-1-((2,4,6-trimethoxyphenyl)methylthio)ethyl}-1,3-oxazolidin-2-one; 2-aAmino-3-methyl-3-((2,4,6-trimethoxyphenyl)methylthio)butan-1-ol; 4-(1-methyl-1-(nitrosothio)ethyl)-1,3-oxazolidin-2-one; or pharmaceutically acceptable salts thereof. The compositions of the invention can further comprise at least one penetration enhancer, at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one vasoactive agent.

    专利号:US-5905091-A
    优先权日:1996-07-03
    标 题 :Enhancement of skin pigmentation by prostaglandins
    发明人:FULLER BRYAN B
    权利人:UNIV OKLAHOMA
    摘要:A composition comprising a carrier and prostaglandin effective in stimulating synthesis of melanin in a human melanocyte thereby enhancing pigmentation of the human skin and optionally comprising a lysosomotropic agent, a phosphodiesterase inhibitor, and/or methylxanthines, and a method of use of the composition. Use of this composition promotes tanning of the human skin and increases photoprotection from ultraviolet radiation.

    专利号:US-2024010511-A1
    优先权日:2019-05-02
    标 题 :Methods and compositions for synthesis of phosphor and its incorporation in a polymer matrix for light conversion
    发明人:SAHI SUNIL
    权利人:SOLGO INC; SOLGRO INC
    摘要:The invention relates to methods and compositions for synthesizing a phosphor and preparing a surface-modified phosphor comprising a phosphor, a silica, and a silane, and articles comprising same. The invention also relates to a method of dispersion of the disclosed surface-modified phosphor with a blue emitting agent in a polymer matrix and uses thereof.
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    参考文献:10.3390/ijms12063786
    摘要:Sun T, Jiang B, Pan B. Microwave accelerated transglycosylation of rutin by cyclodextrin glucanotransferase from Bacillus sp. SK13.002. Int J Mol Sci. 2011;12(6):3786–96.
    参考文献:10.1007/s13346-011-0034-2
    摘要:Turpin JA. Topical microbicides to prevent the transmission of HIV: formulation gaps and challenges. Drug Delivery and Translational Research. 2011 May 21;1(3):194. doi: 10.1007/s13346-011-0034-2.
    参考文献:10.4103/0974-8490.81955
    摘要:Cock IE, Kukkonen L. An examination of the medicinal potential of Scaevola spinescens: Toxicity, antibacterial, and antiviral activities. Pharmacognosy Res. 2011 Apr;3(2):85–94.
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