CAS: 13122-91-3; ((Benzyloxy)Carbonyl)-L-Phenylalanyl-L-Phenylalanine

该化合物是属于氨基酸衍生物类别的合成化合物,其特点是苯丙氧碳基化合物组,该物质增强了其在有机溶剂中的稳定性和溶解性,其特征是其与丙酸相似的结构,由两个苯丙胺残留物组成,由碳基组联系在一起,其存在有助于其疏水特性,而甲基氧组则影响其与生物系统的反作用和相互作用,该化合物可能表现出在制药中的潜在应用,特别是在药物设计和开发中,因为它的结构类似于天然生成的.此外,其独特的特性可能允许与生物目标进行具体互动,使其对药用化学感兴趣.然而,有必要对其生物活动,毒性和药用基因学进行详细研究,以便充分了解其在各个领域的潜在用途和影响.

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2577-40-4 84889-09-8 58607-69-5

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CAS号63-91-2 L-苯丙氨酸 | CAS号769922-77-2 (S)-Benzyl 1-(1... | CAS号1161-13-3 N-苄氧羰基-L-苯丙氨酸 | CAS号4892-10-8 L-Phenylalanine... | CAS号2578-84-9 苯丙氨酸 | CAS号41518-17-6 (S)-(S)-2-(((be... | CAS号7524-50-7 L-苯丙氨酸甲酯盐酸盐 | CAS号63-91-2 L-苯丙氨酸 | CAS号1161-13-3 N-苄氧羰基-L-苯丙氨酸

合成工艺路线路线简述

    📜N-(Benzyloxycarbonyl)-L-Phenylalanyl-L-Phenylalanine Methyl Ester置于sodium Hydroxide体系中,化学反应生成N-苄氧羰基-L-苯丙氨酰基-L-苯丙氨酸
    参考文献:Effects Of Normal And Their Branched Alcohols With Structurally Minimal Variation On Kinetic Parameters In Thermolysin-Catalyzed Peptide Hydrolysis And Synthesis Ofn-(Benzyloxycarbonyl)-L-Phenylalanyl-L-Phenylalanine And Its Methyl Ester
    标题:Effects Of Normal And Their Branched Alcohols With Structurally Minimal Variation On Kinetic Parameters In Thermolysin-Catalyzed Peptide Hydrolysis And Synthesis Ofn-(Benzyloxycarbonyl)-L-Phenylalanyl-L-Phenylalanine And Its Methyl Ester
    摘要:当在反应介质中加入较高的醇类溶剂时,在热溶解酶催化肽水解和合成过程中观测到酶活性增强,随后酶活性降低,最后失活.所使用的有机溶剂含量低于缓冲液(即水有机单相体系)中的饱和浓度.在这些反应中,当酒精浓度达到最大酶活性时,动力学参数 Km 和 Kcat 随酒精对数 P 值的增加而线性变化,因此 Kcat/km 也随之增加.当使用对数 P 值理论上相等的结构变化最小的醇的支链异构体作为附件时,动力学参数也发生了变化.这些结果,尤其是每种有机溶剂的 Km 变化,表明每种醇都以其自身的有效模式作用于酶的活性位点.
    Doi:10.1271/bbb.59.535

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    专利信息


    专利号:US-3725380-A
    优先权日:1969-04-05
    标 题:Method of synthesizing peptides in the presence of a carbodiimide and a 1-hydroxy-benzotriazole
    发明人：KONIG W; GEIGER R
    权利人:HOECHST AG
    摘要:Improved synthesis of peptides by the carbodiimide method in which an amino-protected amino acid or peptide having a reactive carboxy group is condensed with a carboxy-protected amino acid or peptide having a reactive amino group in the presence of a 1hydroxy-benzotriazole or a substituted 1-hydroxy-benzotriazole of the formula AS WELL AS IN THE PRESENCE OF A CARBODIIMIDE SUCH AS DICYCLOHEXYL CARBODIIMIDE.

    专利号:KR-20030002010-A
    优先权日:2001-06-28
    标 题:Protease-catalyzed synthesis of enkephalin in organic aqueous monophasic system

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    主要参考文献

    参考标题:α-N-Protected Dipeptide Acids: A Simple And Efficient Synthesis Via The Easily Accessible Mixed Anhydride Method Using Free Amino Acids In Dmso And Tetrabutylammonium Hydroxide
    作者:G. Verardo,A. Gorassini |发布日期:2013.5
    摘要:To Find Simple And Efficient Methods For Their Synthesis. For This Reason, We Have Investigated The Synthesis Of α‐n‐protected Dipeptide Acids By Reacting The Easily Accessible Mixed Anhydride Of α‐n‐protected Amino Acids With Free Amino Acids Under Different Reaction Conditions. The Combination Of Tba‐oh And Dmso Has Been Found To Be The Best To Overcome The Low Solubility Of Amino Acids In Organic

    合成参考文献


    参考文献:10.1007/bf00164731
    摘要:Nakanishi K, Takeuchi A, Matsuno R. Long-term continuous synthesis of aspartame precursor in a column reactor with an immobilized thermolysin. Appl Microbiol Biotechnol. 1990 Mar;32(6):633–6. doi: 10.1007/bf00164731.
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