CAS: 123333-71-1; Dl-Histidine Monohydrochloride Monohydrate

相似化合物

5934-29-2 109425-51-6 135610-90-1

专利信息

专利号:US-6620942-B2
优先权日:1998-12-23
标题 :Synthesis of histamine dihydrochloride
发明人：YEH WEN-LUNG; ANTCZAK CASIMIR; MCGOLRICK JEFFRY DAVID; ROTH MICHAEL JOSEPH; WRONA MARK
权利人:MAXIM PHARMACEUTICALS
摘要:The invention disclosed herein relates to the preparation of pharmaceutical grades of histamine dihydrochloride using a two step non-enzymatic synthetic method. The invention disclosed herein describes the synthesis of histamine dihydrochloride by the non-enzymatic decarboxylation of histidine and the step-wise conversion of the decarboxylated product to the dihydrochloride salt form. The invention disclosed herein considers a final product of histamine dihydrochloride containing less than each of the following: 0.8% L -histidine HCl monohydrate, 0.1% individual chromatographic impurities, and 2% total impurities, to be acceptable for pharmaceutical use.

专利号:US-11718864-B2
优先权日:2015-09-23
标 题 :Cells and method of cell culture
发明人：HILLER GREGORY WALTER; MITCHELL JEFFREY JOSEPH; MULUKUTLA BHANU CHANDRA; PEGMAN PAMELA MARY
权利人:PFIZER
摘要:The invention relates to a method of cell culture where the cells are modified to reduce the level of synthesis of growth and/or productivity inhibitors by the cell. The invention also relates to a method of cell culture for improving cell growth and productivity, in particular in fed-batch culture of mammalian cells at high cell density. The invention further relates to a method of producing cells with improved cell growth and/or productivity in cell culture and to cells obtained or obtainable by such methods.

专利号:US-2002035268-A1
优先权日:1998-12-23
标题 :Synthesis of histamine dihydrochloride

专利号:US-2003138964-A1
优先权日:1998-12-23
标题 :Synthesis of histamine dihydrochloride

专利号:US-2006281148-A1
优先权日:2005-06-10
标题:Cell-free extracts and synthesis of active hydrogenase

专利号:US-7351563-B2
优先权日:2005-06-10
标题 :Cell-free extracts and synthesis of active hydrogenase
发明人：SWARTZ JAMES ROBERT; BOYER MARCUS EMIL; STAPLETON JAMES ALAN; SPORMANN ALFRED M; WANG CHIA-WEI
权利人:UNIV LELAND STANFORD JUNIOR
摘要:Enzymatically active hydrogenase is synthesized in a cell-free reaction. The hydrogenases are synthesized in a cell-free reaction comprising a cell extract derived from microbial strains expressing at least one hydrogenase accessory protein. In some embodiments, the extracts are produced under anerobic conditions.