专利号:US-10005720-B2 优先权日:2013-04-05 标题:Compounds useful for the treatment of metabolic disorders and synthesis of the same 发明人:SEXTON JONATHAN Z; BRENMAN JAY E; MUSSO DAVID L 权利人:NORTH CAROLINA CENTRAL UNIV; UNIV NORTH CAROLINA CHAPEL HILL 摘要:The present invention provides compounds of Formula (I): wherein variables X, Y, Z and R1 are as described herein. Some of the compounds described herein are glutamate dehydrogenase activators. The invention is also directed to pharmaceutical compositions comprising these compounds, uses of these compounds and compositions in the treatment of metabolic disorders as well as synthesis of the compounds.
专利号:US-2018370905-A1 优先权日:2013-04-05 标题:Compounds Useful for the Treatment of Metabolic Disorders and Synthesis of the Same
专利号:US-2016046560-A1 优先权日:2013-04-05 标题 :Compounds useful for the treatment of metabolic disorders and synthesis of the same
专利号:WO-2014165816-A1 优先权日:2013-04-05 标 题 :Compounds useful for the treatment of metabolic disorders and synthesis of the same
专利号:EP-3766543-A1 优先权日:2019-07-19 标 题:N-aryl derivatives for treating a rna virus infection 权利人:ABIVAX; CENTRE NAT RECH SCIENT; UNIV MONTPELLIER; INST CURIE 摘要:wherein: nX 2 represents a -CO-NRk- group, a -NR'k-CO- group, a -O- group, a -CO- group, a -SO 2 -group, a -CS-NH- group, a -CH 2 -NH-, an ngroup, or a divalent 5-membered heteroaromatic ring comprising 1, 2, 3 or 4 heteroatoms; Y 2 represents a hydrogen atom, a halogen atom, a hydroxyl group, a morpholinyl group, optionally substituted by a (C 1 -C 4 )alkyl group, a piperidinyl group, a (C 1 -C 4 )alkenyl group, a -PO(OR a )(OR b ) group, Or a -CR 1 R 2 R 3 group, or any of its pharmaceutically acceptable salt. n The present invention further relates to new compounds, to pharmaceutical compositions containing them and to synthesis process for manufacturing them.
摘要:Silva, V. L. M.; Pinto, D. C. G. A.; Santos, C. M. M.; Rocha, D. H. A., Science of Synthesis Knowledge Updates, (2022) 3, 382. 摘要:Clark, K. F.; Dimitrova, D.; Murphy, J. A., Science of Synthesis, (2020) , 42.