CAS: 1020172-07-9; 4-(4-(3-(3-(Tert-Butyl)-1-(Quinolin-6-yl)-1H-Pyrazol-5-yl)Ureido)-3-Fluorophenoxy)-N-Methylpicolinamide

上下游产品

CAS号757251-39-1 4-(4-氨基-3-氟苯氧基)... | CAS号580-16-5 6-羟基喹啉 | CAS号173089-80-0 三氟甲磺酸6-喹啉酯 | CAS号59997-51-2 新戊酰基乙腈 | CAS号399-95-1 4-氨基-3-氟苯酚 | CAS号220000-87-3 N-甲基-4-氯吡啶-2-甲酰胺 | CAS号53750-66-6 4-氯吡啶-2-甲酰氯

📜新戊酰基乙腈置于盐酸,4-二甲氨基吡啶,N,N-二异丙基乙胺体系中,用 乙醇,二氯甲烷,水,二甲基亚砜 用作溶剂,化学反应 9.33H,反应生成N-[3-叔丁基-1-(喹啉-6-基)-1H-吡唑-5-基]-N'-[2-氟-4-[(2-(甲基氨基甲酰基)吡啶-4-基)氧]苯基]脲
参考文献:Methods Of Using Rebastinib In The Treatment Of Disorders
标题:Methods Of Using Rebastinib In The Treatment Of Disorders
摘要:本文描述了治疗患有各种疾病的患者的方法,包括向患者施用化合物i的药物或其药用盐.本文描述的方法可以治疗的示例疾病包括妇科肉瘤,子宫内膜腺癌,间皮瘤,卵巢癌,胰腺导管腺癌和肺癌.

专利信息

专利号:US-2017283878-A1
优先权日:2015-12-11
标题:Modulation of globoseries glycosphingolipid synthesis and cancer biomarkers
发明人：WONG CHI-HUEY; WU CHUNG-YI; CHEUNG SARAH K C; CHUANG PO-KAI; HSU TSUI-LING
权利人:ACADEMIA SINICA
摘要:The present disclosure relates to methods and compositions which can modulate the globoseries glycosphingolipid synthesis. Particularly, the present disclosure is directed to glycoenzyme inhibitor compound and compositions and methods of use thereof that can modulate the synthesis of globoseries glycosphingolipid SSEA-3/SSEA-4/GloboH in the biosynthetic pathway; particularly, the glycoenzyme inhibitors target the alpha-4GalT; beta-4GalNAcT-I; or beta-3GalT-V enzymes in the globoseries synthetic pathway. Additionally, the present disclosure is also directed to vaccines, antibodies, and/or immunogenic conjugate compositions targeting the SSEA-3/SSEA-4/GLOBO H associated epitopes (natural and modified) which elicit antibodies and/or binding fragment production useful for modulating the globoseries glycosphingolipid synthesis. Moreover, the present disclosure is also directed to the method of using the compositions described herein for the treatment or detection of hyperproliferative diseases and/or conditions. Furthermore, the instant disclosure also relates to cancer stem cell biomarkers for diagnostic and therapeutic uses.

专利号:WO-2025128098-A1
优先权日:2023-12-13
标 题 :Solid oral dosage forms, kits, and methods of using the same
发明人：LI YING; LANGER ROBERT; TRAVERSO CARLO
权利人:MASSACHUSETTS INST TECHNOLOGY; BRIGHAM & WOMENS HOSPITAL INC
摘要:Provided herein are solid oral dosage forms, methods, and kits useful, e.g, for the extension of the residence time of active pharmaceutical agents in vivo by the synthesis of a polymer in situ in a subject. In particular, the solid oral dosage forms, methods, and kits disclosed herein are particularly useful for drugs that require more than once daily administration (e.g, drugs that have short half-lives).

专利号:US-11753392-B2
优先权日:2018-04-13
标题:Method for synthesis of deuterated amide and deuterated sulfonamide
发明人：DU WU; WEN KUN; HE JINYUN; LI HAIBO; QIN DEKUN; LI XINGHAI; CHEN YUANWEI
权利人:HINOVA PHARMACEUTICALS INC
摘要:A novel method for synthesizing deuterated amides and deuterated sulfonamides includes the following steps: (1) adding a compound M, DMAP, R3—X to a solvent to obtain a compound N after a reaction is complete; and (2) adding the compound N, R4—NH—R5, or a salt and base thereof to a solvent, and purifying after a reaction is complete to obtain a compound I.

专利号:US-12180228-B2
优先权日:2019-06-05
标题:Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof
发明人：MOVASSAGHI MOHAMMAD; OLSSON CHASE ROBERT; SCOTT TONY Z; CHEAH JAIME; PAYETTE JOSHUA NATHANIEL
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:The present disclosure provides, e.g., compounds, compositions, kits, methods of synthesis, and methods of use, involving epipolythiodiketopiperazines and polythiodiketopiperazines.

专利号:US-2021115009-A1
优先权日:2018-04-13
标 题 :Method for synthesis of deuterated amide and deuterated sulfonamide

专利号:CA-3096963-A1
优先权日:2018-04-13
标题:A new method for synthesis of deuterated amide and deuterated sulfonamide