CAS: 1001-19-0; H-D-Glu(Oet)-Oet.Hcl

相似化合物

1118-89-4 138-15-8 1499-55-4

专利信息

专利号:US-2012282652-A1
优先权日:2011-02-28
标题 :Preparation of peptide mixtures by protease catalysis designed to provide useful biological and physical properties
发明人：GROSS RICHARD A; VISWANATHAN KODANDARAMAN; QIN XU
权利人:GROSS RICHARD A; VISWANATHAN KODANDARAMAN; QIN XU; POLITECHNIC INST UNIV NEW YORK
摘要:A process for preparing unique peptide mixtures with a broad range of uses using combinations of natural and non-natural amino acid alkyl ester monomers and specific combinations of these monomers as dimers, trimers and higher oligomers selected from the large group of structural motifs that lead to useful physical and/or biological properties and that have been or may be identified from solid state peptide synthesis, isolation of peptides from natural sources, and production of peptides by recombinant DNA methods, or identification of peptides by recombinant methods such as phage display, the method of peptide synthesis comprising a) admixing one or more natural and non-natural amino acid alkyl ester monomer, dimer, trimer and higher oligomers with one or more proteases in a reaction medium; b) heating the mixture to between about 5° C. to about 90° C. for between 5 minutes and 24 hours; and c) recovering the formed oligopeptide.

专利号:CN-109734698-B
优先权日:2019-01-25
标 题 :A kind of synthesis technique of raltitrexed key intermediate

专利号:CN-109734698-A
优先权日:2019-01-25
标 题 :A kind of synthesis technique of raltitrexed key intermediate

专利号:US-5723607-A
优先权日:1993-01-29
标题:Compounds useful as antiproliferative agents and GARFT inhibitors
发明人：VARNEY MICHAEL D; ROMINES WILLIAM H; PALMER CYNTHIA L
权利人:AGOURON PHARMACETICALS INC
摘要:The invention generally relates to compounds of the formula I, which are in equilibrium with their 4-hydroxy tautomers, and their pharmaceutically acceptable salts: where n is 0 to 2; A is S, CH2, O, NH or Se, and when n is 0, A is not CH2, and when n is 1, A is not CH2 or NH; X is a substituted or unsubstituted C1-C3 alkyl, C2-C3 alkenyl, C2-C3 alkynyl or amino, or sulfur or oxygen; Ar is a substituted or unsubstituted monocyclic carbocycle or heterocycle, or fused or nonfused polycyclic carbocycle or heterocycle; and R1 and R2 are hydrogen or a moiety that forms together with the attached CO2 a readily hydrolyzable ester group. These compounds and their salts are useful as inhibitors of GARFT or as antiproliferative agents. The invention also pertains to pharmaceutical compositions and methods employing such compounds as GARFT inhibitors or antiproliferative agents. The invention also relates to compounds useful as intermediates for preparing such compounds, and to their synthesis.

专利号:CN-118239850-A
优先权日:2024-04-24
标 题:Synthesis and application of α-alkylglycine derivatives