CAS: 935288-20-3; 1-Bromo-4-Fluoro-2-Methoxy-5-Nitrobenzene
- 英文名称1-Bromo-4-Fluoro-2-Methoxy-5-Nitrobenzene
- 中文名称1-溴-4-氟-2-甲氧基-5-硝基苯
- IUPAC名称1-bromo-4-fluoro-2-methoxy-5-nitrobenzene
- 其它别名2-溴-5-氟-4-硝基苯甲醚; 1-Bromo-4-Fluoro-2-Methoxy-5-Nitro-Benzene
- CAS编号935288-20-3
- MFCD编号:MFCD25969224
- 分子式:C7H5BrFNO3分子量:250.02
- 产品CID: 1974850
- 产品分类有机原料→分子砌块→芳环类化合物→苯类化合物
物理性质
MSDS等安全信息
上下游产品
5-bromo-2,4-difluoronitrobenzene sodium methylate 1-bromo-4-fluoro-2-methoxybenzene 4-fluoro-2-methoxyaniline 1-(2-bromo-5-methoxy-4-nitrophenyl)-4-methylpiperazine 1-(4-bromo-5-methoxy-2-nitrophenyl)-4-methylpiperazine合成工艺路线路线简述
- 1075705-01-9 = 935288-20-3
反应条件:1.1 Reagents: Tert-Butyl Nitrite,Copper Bromide (Cubr2) Solvents: Acetonitrile; Rt -> 50 °C; 50 °C; 2.5 H,50 °C
标题:Preparation Of Pyrimidine Derivatives As Egfr Inhibitors
参考文献:China]
450-88-4 = 935288-20-3
反应条件:1.1 Reagents: Sulfuric Acid,Nitric Acid; Rt -> 0 °C; 0 °C; 30 Min,0 °C
标题:Benzimidazol-2-Amines As Midh1 Inhibitors And Their Preparation
参考文献:World Intellectual Property Organization]
450-88-4 = 935288-20-3
反应条件:1.1 Reagents: Sulfuric Acid,Nitric Acid; Cooled; 30 Min,0 °C
标题:Preparation Of The Benzimidazole Compounds And Their Medical Application As Idh Inhibitor
参考文献:World Intellectual Property Organization]
345-24-4 = 935288-20-3 + 1352244-77-9
反应条件:1.1 Solvents: Methanol; 2 H,0 °C; 20 H,Rt
标题:Preparation Of N-Pyridinyl And N-Benzofuranyl Carboxamides And Their Analogs Useful As Tead Modulators
参考文献:World Intellectual Property Organization]
345-24-4 = 935288-20-3 + 1352244-77-9
反应条件:1.1 Solvents: Methanol; 0 °C; 10 H,Rt; 8 H,Reflux
标题:Heterocyclic Compounds As Bromodomain Inhibitors And Their Preparation
参考文献:World Intellectual Property Organization]
450-88-4 = 935288-20-3
反应条件:1.1 Reagents: Sulfuric Acid,Fuming Nitric Acid; 0 °C; 30 Min,0 °C
标题:Preparation Of 5-Hydroxyalkylbenzimidazoles As Midh1 Inhibitors
参考文献:World Intellectual Property Organization]
450-88-4 = 935288-20-3
反应条件:1.1 Reagents: Sulfuric Acid,Fuming Nitric Acid; 0 °C; 30 Min,0 °C
标题:2-Aryl- And 2-Arylalkylbenzimidazoles As Midh1 Inhibitors And Their Preparation
参考文献:World Intellectual Property Organization]
450-88-4 = 935288-20-3
反应条件:1.1 Reagents: Sulfuric Acid,Potassium Nitrate; Cooled; 1 H,Rt
标题:Preparation Of 2-Arylaminopyridine,Pyrimidine Or Triazine Derivatives As Antitumor Agents
参考文献:China]
345-24-4 = 935288-20-3 + 1352244-77-9
反应条件:1.1 Solvents: Methanol; 2 H,0 °C; 20 H,Rt
标题:Carboxamide And Sulfonamide Derivatives Useful As Tead Modulators And Their Preparation
参考文献:World Intellectual Property Organization]
345-24-4 = 935288-20-3 + 1352244-77-9
反应条件:1.1 Reagents: Sodium Methoxide; 2 H,0 °C
标题:Macrocyclic Compounds As Alk,Fak And Jak2 Inhibitors And Their Preparation And Use For The Treatment Of Alk-,Fak- And Jak2-Mediated Diseases
参考文献:World Intellectual Property Organization]
345-24-4 = 935288-20-3 + 1352244-77-9
反应条件:1.1 Solvents: Methanol; 2 H,0 °C
标题:Design,Synthesis,And Anaplastic Lymphoma Kinase (Alk) Inhibitory Activity For A Novel Series Of 2,4,8,22-Tetraazatetracyclo[14.3.1.13,7.19,13]Docosa-1(20),3(22),4,6,9(21),10,12,16,18-Nonaene Macrocycles
作者:Breslin,Henry J.; Lane,Brandon M.; Ott,Gregory R.; Ghose,Arup K.; Angeles,Thelma S.; Et Al
参考文献:Journal Of Medicinal Chemistry 日期:2012 卷标:55(1) 页码:449-464
📜4-氟-2-甲氧基-5-硝基苯胺置于copper(Ll) Bromide,亚硝酸异戊酯体系中,用 乙腈 作为反应溶剂,以88.1 %的收率获得产物1-溴-4-氟-2-甲氧基-5-硝基苯
参考文献:一种连续流重氮化反应制备4-硝基-2-溴-5-氟苯甲醚的方法
标题:一种连续流重氮化反应制备4-硝基-2-溴-5-氟苯甲醚的方法
摘要:本申请涉及重氮化反应方法领域,具体公开了一种连续流重氮化反应制备4‑硝基‑2‑溴‑5‑氟苯甲醚的方法.本申请的方法包括以下步骤:S1,制备原料液a:乙腈,4‑氟‑2‑甲氧基‑5‑硝基苯胺,混合溶解,反应得到原料液a;s2,制备原料液b:乙腈,溴化铜,亚硝酸异戊酯,混合溶解,反应得到原料液b;s3,通过泵将原料液a和原料液b输送至连续搅拌全混反应器,得到反应液;s4,对反应液进行脱溶,洗涤,吸附,再次脱溶结晶,过滤分离,得到4‑硝基‑2‑溴‑5‑氟苯甲醚.本申请中的连续流重氮化技术中具有原料更温和,安全风险低,物料处理量大,产品的收率高的优点.
海关参考信息
- 2905110000-甲醇
2908199090-其他酚的卤化衍生物
2908999090-其他酚的硝化衍生物
2918290000-其他含酚基羧酸 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
