CAS: 915759-45-4; 5-(Phenylsulfonyl)-N-(Piperidin-4-yl)-2-(Trifluoromethyl)Benzenesulfonamide
该化合物是一个小分子抑制器,以其选择性地对抗在骨骼代谢中起着关键作用的螺旋状蛋白而闻名. 3166606号路径通过对螺旋状物的束缚,有效地阻断了Wnt/ β-卡特宁信号的抑制,从而促进了骨质活性和骨质形成. 该化合物被广泛用于临床前研究,以调查骨质疏松和其他与骨骼有关的疾病的潜在治疗应用. 它的高度特性和精细化的行动机制使其成为研究骨骼生物学和断层路径调节的宝贵工具. 研究人员赞成3166606号路径在体外和活体模型中进行再生和再生.
- 英文名称5-(Phenylsulfonyl)-N-(Piperidin-4-yl)-2-(Trifluoromethyl)Benzenesulfonamide
- 中文名称5-(苯磺酰基)-N-(哌啶-4-基)-2-(三氟甲基)苯磺酰胺; WAY 316606
- IUPAC名称5-(phenylsulfonyl)-N-(piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide
- CAS编号915759-45-4
- MFCD编号:MFCD18206894
- 分子式:C18H19F3N2O4S2分子量:448.49
- 产品CID: 1952656
- 同类组份化合物CAS915759-45-4 (free base)1781835-02-6 (HCl)
- 产品分类生物化工 → 生化试剂 → 激动剂抑制剂
物理性质
- 沸点601.1±65.0 °C(预测)
- 密度1.50±0.1 g/cm3(预测)
- pKa:8.76±0.20(预测)
- 溶解性DMF: 3 mg/mL; DMSO: 3 mg/mL; DMSO:Pbs (Ph 7.2) (1:10): 0.1 mg/mL
- 外观形态白色至类白色粉末
- 储存条件Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
- 产品应用该化合物是SFRP1号特定敌国,它激活了人类毛发囊中的弹簧/Β-卡特宁信号;它增加了新生儿肾上腺胆碱酯酶试验中的骨骼形成,以依赖剂量的方式将总骨骼面积增加高达60%.
上下游产品
T-Butyl 4-({[5-(Phenylsulfonyl)-2-(Trifluoromethyl)Phenyl]Sulfonyl}Amino)-1-Carboxylate 915759-44-3合成工艺路线路线简述
- 915763-83-6 = 915759-45-4
反应条件:1.1 Reagents: Acetic Acid,Hydrochloric Acid Solvents: Acetonitrile,Water; 0 °C1.2 Reagents: Sodium Nitrite Solvents: Water; 10 Min,0 °C; 20 Min,0 °C1.3 Reagents: Sulfur Dioxide; 20 Min,0 °C1.4 Reagents: Cupric Chloride Solvents: Water; 0 °C -> Rt; Overnight,Rt2.1 Reagents: Triethylamine Solvents: Dichloromethane; 2 Min,Rt; 1 H,Rt3.1 Reagents: Hydrochloric Acid Solvents: 1,4-Dioxane; Overnight,Rt
标题:Modulation Of Wnt Signaling Through Inhibition Of Secreted Frizzled-Related Protein I (Sfrp-1) With N-Substituted Piperidinyl Diphenylsulfonyl Sulfonamides
作者:Moore,William J.; Et Al
参考文献:Journal Of Medicinal Chemistry 日期:2009 卷标:52(1) 页码:105-116]
75-61-6 + 4779-36-6 = 915759-45-4
反应条件:1.1 Reagents: Copper Solvents: Dimethylacetamide; Rt -> 100 °C; 6 H,100 °C; 100 °C -> Rt2.1 Reagents: Stannous Chloride Solvents: Methanol,Water; 3 D,Rt -> 70 °C; 70 °C -> Rt2.2 Reagents: Sodium Bicarbonate Solvents: Water3.1 Reagents: Acetic Acid,Hydrochloric Acid Solvents: Acetonitrile,Water; 0 °C3.2 Reagents: Sodium Nitrite Solvents: Water; 10 Min,0 °C; 20 Min,0 °C3.3 Reagents: Sulfur Dioxide; 20 Min,0 °C3.4 Reagents: Cupric Chloride Solvents: Water; 0 °C -> Rt; Overnight,Rt4.1 Reagents: Triethylamine Solvents: Dichloromethane; 2 Min,Rt; 1 H,Rt5.1 Reagents: Hydrochloric Acid Solvents: 1,4-Dioxane; Overnight,Rt
标题:Modulation Of Wnt Signaling Through Inhibition Of Secreted Frizzled-Related Protein I (Sfrp-1) With N-Substituted Piperidinyl Diphenylsulfonyl Sulfonamides
作者:Moore,William J.; Et Al
参考文献:Journal Of Medicinal Chemistry 日期:2009 卷标:52(1) 页码:105-116]
915759-44-3 = 915759-45-4
反应条件:1.1 Reagents: Hydrochloric Acid Solvents: 1,4-Dioxane; Overnight,Rt
标题:Modulation Of Wnt Signaling Through Inhibition Of Secreted Frizzled-Related Protein I (Sfrp-1) With N-Substituted Piperidinyl Diphenylsulfonyl Sulfonamides
作者:Moore,William J.; Et Al
参考文献:Journal Of Medicinal Chemistry 日期:2009 卷标:52(1) 页码:105-116]
915763-84-7 = 915759-45-4
反应条件:1.1 Reagents: Triethylamine Solvents: Dichloromethane; 2 Min,Rt; 1 H,Rt2.1 Reagents: Hydrochloric Acid Solvents: 1,4-Dioxane; Overnight,Rt
标题:Modulation Of Wnt Signaling Through Inhibition Of Secreted Frizzled-Related Protein I (Sfrp-1) With N-Substituted Piperidinyl Diphenylsulfonyl Sulfonamides
作者:Moore,William J.; Et Al
参考文献:Journal Of Medicinal Chemistry 日期:2009 卷标:52(1) 页码:105-116]
915763-82-5 = 915759-45-4
反应条件:1.1 Reagents: Stannous Chloride Solvents: Methanol,Water; 3 D,Rt -> 70 °C; 70 °C -> Rt1.2 Reagents: Sodium Bicarbonate Solvents: Water2.1 Reagents: Acetic Acid,Hydrochloric Acid Solvents: Acetonitrile,Water; 0 °C2.2 Reagents: Sodium Nitrite Solvents: Water; 10 Min,0 °C; 20 Min,0 °C2.3 Reagents: Sulfur Dioxide; 20 Min,0 °C2.4 Reagents: Cupric Chloride Solvents: Water; 0 °C -> Rt; Overnight,Rt3.1 Reagents: Triethylamine Solvents: Dichloromethane; 2 Min,Rt; 1 H,Rt4.1 Reagents: Hydrochloric Acid Solvents: 1,4-Dioxane; Overnight,Rt
标题:Modulation Of Wnt Signaling Through Inhibition Of Secreted Frizzled-Related Protein I (Sfrp-1) With N-Substituted Piperidinyl Diphenylsulfonyl Sulfonamides
作者:Moore,William J.; Et Al
参考文献:Journal Of Medicinal Chemistry 日期:2009 卷标:52(1) 页码:105-116]
97-08-5 = 915759-45-4
反应条件:1.1 Catalysts: Aluminum Chloride Solvents: Benzene; 2 D,Rt2.1 Reagents: Copper Solvents: Dimethylacetamide; Rt -> 100 °C; 6 H,100 °C; 100 °C -> Rt3.1 Reagents: Stannous Chloride Solvents: Methanol,Water; 3 D,Rt -> 70 °C; 70 °C -> Rt3.2 Reagents: Sodium Bicarbonate Solvents: Water4.1 Reagents: Acetic Acid,Hydrochloric Acid Solvents: Acetonitrile,Water; 0 °C4.2 Reagents: Sodium Nitrite Solvents: Water; 10 Min,0 °C; 20 Min,0 °C4.3 Reagents: Sulfur Dioxide; 20 Min,0 °C4.4 Reagents: Cupric Chloride Solvents: Water; 0 °C -> Rt; Overnight,Rt5.1 Reagents: Triethylamine Solvents: Dichloromethane; 2 Min,Rt; 1 H,Rt6.1 Reagents: Hydrochloric Acid Solvents: 1,4-Dioxane; Overnight,Rt
标题:Modulation Of Wnt Signaling Through Inhibition Of Secreted Frizzled-Related Protein I (Sfrp-1) With N-Substituted Piperidinyl Diphenylsulfonyl Sulfonamides
作者:Moore,William J.; Et Al
参考文献:Journal Of Medicinal Chemistry 日期:2009 卷标:52(1) 页码:105-116
📜T-Butyl 4-({[5-(Phenylsulfonyl)-2-(Trifluoromethyl)Phenyl]Sulfonyl}Amino)-1-Carboxylate,在 碳酸氢钠,乙酸乙酯,Brine,Magnesium Sulfate体系中,用 盐酸,1,4-二氧六环 作为反应溶剂,化学反应 16.0H,以to Give 5-(Phenylsulfonyl)-N-Piperidin-4-Yl-2-(Trifluoromethyl)Benzenesulfonamide (1.1 G,85%)的收率获得产物5-(苯磺酰基)-N-(哌啶-4-基)-2-(三氟甲基)苯磺酰胺; Way 316606
参考文献:Diarylsulfone Sulfonamides And Use Thereof
标题:Diarylsulfone Sulfonamides And Use Thereof
摘要:提供公式1的化合物或其药用可接受盐:它们是分泌的毛细胞突变相关蛋白-1的调节剂.这些化合物和含有这些化合物的组合物可用于治疗多种疾病,包括骨质疏松症.
海关参考信息
- 2902300000-甲苯
2903399090-其他无环烃卤化衍生物
2921199090-其他无环单胺
2930909099-其他有机硫化合物 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:CN-114920686-B
优先权日:2022-05-20
标题:Synthesis method of 5- (benzenesulfonyl) -N-piperidin-4-yl-2- (trifluoromethyl) benzenesulfonamide hydrochloride
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Bodine PV, Stauffer B, Ponce-de-Leon H, Bhat RA, Mangine A, Seestaller-Wehr LM, Moran RA, Billiard J, Fukayama S, Komm BS, Pitts K, Krishnamurthy G, Gopalsamy A, Shi M, Kern JC, Commons TJ, Woodworth RP, Wilson MA, Welmaker GS, Trybulski EJ, Moore WJ. A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation. Bone. 2009 Jun;44(6):1063-8. doi: 10.1016/j.bone.2009.02.013. Epub 2009 Feb 27. doi: 10.1021/jm801144h.
合成参考文献
参考文献:10.1371/journal.pbio.2003705
摘要:Hawkshaw NJ, Hardman JA, Haslam IS, Shahmalak A, Gilhar A, Lim X, Paus R. Identifying novel strategies for treating human hair loss disorders: Cyclosporine A suppresses the Wnt inhibitor, SFRP1, in the dermal papilla of human scalp hair follicles. PLoS Biol. 2018 May 08;16(5):e2003705. doi: 10.1371/journal.pbio.2003705.
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尽可能描述清楚需求与问题信息
