CAS: 851199-85-4; Pyrimidin-2-Ylboronic Acid

该化合物是一种乙酸衍生物乙酸,广泛用于铃木-米亚乌拉的合成双aryl和异丙烯化合物的交叉相交反应,其环具有稳定性和回活性,使其成为制药和农用化学研究的宝贵基石. 丁酸功能组可高效地与丙烯或乙烯酸盐交配,便利复杂的分子结构的建造. 这种复合体显示普通有机溶剂的溶解性良好,在合成应用中提高了其效用. 它的一贯性能和兼容性与各种反应条件的兼容性,使它成为需要精确的C-C联系的医药化学和材料科学应用的首选.

结构式图片

上下游产品

Trimethyl borate water 2-bromopyrimidineN-(3-((dimethylamino)methyl)phenyl)-4-(pyrimidin-2-yl)benzenesulfonamide 2-(4-bromophenyl)pyrimidine 4-methoxycarbonyl aniline

合成工艺路线路线简述

  • 合成目标产物 Pyrimidin-2-Ylboronic Acid 主要起始原料 Trimethyl Borate And Water And 2-Bromopyrimidine
  • (文献来源)合成步骤主要原料 Trimethyl Borate 和 Water 和 2-Bromopyrimidine
📜硼酸三甲酯,水,2-溴嘧啶置于正丁基锂,盐酸体系中,用 乙醚 作为反应溶剂,化学反应 13.5H,反应生成 嘧啶-2-硼酸
参考文献:空间电荷转移化合物及有机发光二极管和显示装置
标题:空间电荷转移化合物及有机发光二极管和显示装置
摘要:本发明提供了一种空间电荷转移化合物及有机发光二极管和显示装置.所述空间转移化合物具有式1:[式1]

专利信息


专利号:US-2023212216-A1
优先权日:2019-12-20
标 题:Synthesis of lactone derivatives and their use in the modification of proteins
发明人:MORRIS ALEXANDER REDFERN; SUTOV GRIGORIJ; BRUNE KARL DIETRICH
权利人:GENIE BIOTECH UK LTD
摘要:Site-specific modifications of proteins are desirable in biotechnological applications such as biopharmaceuticals, immunotherapy, vaccines, and are useful in chemical biology. Gluconoylation is a non-enzymatic, covalent, post-translational modification commonly observed on N-terminal His-Tags bearing proteins. We synthesized glucono-1,5-lactone derivatives, including azido variants for selective acylation. High yield acylation is achieved by simply mixing derivatives with target protein amidst diverse conditions of temperatures, aqueous buffers, excipients, or complex cell lysate.

专利号:AU-2020409711-A1
优先权日:2019-12-20
标题 :Synthesis of lactone derivatives and their use in the modification of proteins

专利号:EP-4076533-A1
优先权日:2019-12-20
标 题:Synthesis of lactone derivatives and their use in the modification of proteins

专利号:CA-3164962-A1
优先权日:2019-12-20
标题 :Synthesis of lactone derivatives and their use in the modification of proteins

专利号:WO-2021123229-A1
优先权日:2019-12-20
标题:Synthesis of lactone derivatives and their use in the modification of proteins

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

合成参考文献


参考文献:10.1371/journal.pone.0029585
摘要:Dasgupta I, Tanifum EA, Srivastava M, Phatak SS, Cavasotto CN, Analoui M, Annapragada A. Non Inflammatory Boronate Based Glucose-Responsive Insulin Delivery Systems. PLoS ONE. 2012 Jan 17;7(1):e29585. doi: 10.1371/journal.pone.0029585.
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