CAS: 83-47-6; γ-Sitosterol

上下游产品

3β-Acetoxysitosterol 4651-54-1
Daucosterol 474-58-8

📜(22R)-6β-Methoxy-3α,5-Cyclo-27-Nor-5α-Cholest-23-Yn-22-Ol置于palladium On Activated Charcoal,Lindlar'S Catalyst 喹啉,Lithium Aluminium Tetrahydride,氢气,对甲苯磺酸体系中,用 四氢呋喃,1,4-二氧六环,吡啶,水,乙酸乙酯,Xylene 作为反应溶剂,化学反应 8.0H,反应生成 穿贝海绵甾醇22,23-二氢多孔甾醇24-γ-乙基胆固醇
参考文献:Fujimoto,Yoshinori; Kimura,Miki; Khalifa,Fathy A. M.,Chemical And Pharmaceutical Bulletin,1984,Vol. 32,# 11,P. 4372-4381
标题:Fujimoto,Yoshinori; Kimura,Miki; Khalifa,Fathy A. M.,Chemical And Pharmaceutical Bulletin,1984,Vol. 32,# 11,P. 4372-4381

专利信息

专利号:US-2025049714-A1
优先权日:2021-12-09
标题 :Synthesis of ester, carbonate, and carbamate-derived novel biodegradable ionizable lipids from methyl ricinoleate or methyl 12-hydroxystearate and its applications
发明人：ANDERSON DANIEL GRIFFITH; RHYM LUKE HYUNSIK; LI BOWEN; GORDON AKIVA; RAJITH SINGH MANAN; WITTEN JACOB
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:Provided herein are compounds, such as compounds of Formula (I), and pharmaceutically acceptable salts, hydrates, solvates, polymorphs, co-crystals, tautomers, stereoisomers, and isotopically labeled derivatives thereof, and compositions, methods, uses, and kits thereof. The compounds provided herein are lipids useful for delivery of polynucleotides, such as mRNA, for the treatment and/or prevention of various diseases and conditions (e.g., genetic disease, proliferative disease, hematological disease, neurological disease, liver disease, spleen disease, lung disease, painful condition, psychiatric disorder, musculoskeletal disease, a metabolic disorder, inflammatory disease, or autoimmune disease).

专利号:US-2024226302-A1
优先权日:2022-12-27
标题:Biodegradable lipids and formulations for intramuscular, in vitro, and ex vivo transfection of mrna
发明人：ANDERSON DANIEL GRIFFITH; RUDRA AMAB; GUPTA AKASH; REED KAELAN
权利人:MASSACHUSETTS INST TECHNOLOGY; CHILDRENS MEDICAL CENTER
摘要:Provided herein are compounds, such as compounds of Formula (I), and pharmaceutically acceptable salts thereof, and compositions, methods, uses, and kits thereof. The compounds provided herein are lipids useful for delivery of agents, including polynucleotides such as mRNA, for the treatment and/or prevention of various diseases and conditions (e.g., genetic diseases, proliferative diseases, hematological diseases, neurological diseases, liver diseases, spleen diseases, lung diseases, painful conditions, psychiatric disorders, musculoskeletal diseases, metabolic disorders, inflammatory diseases, and autoimmune diseases). Also provided herein are methods of synthesis of compounds of Formulae (I) and (II).

专利号:US-2025205158-A1
优先权日:2023-12-26
标 题 :Biodegradable lipids and formulations for delivery of mrna
发明人：ANDERSON DANIEL GRIFFITH; RUDRA ARNAB; GUPTA AKASH; REED KAELAN
权利人:MASSACHUSETTS INST TECHNOLOGY; CHILDRENS MEDICAL CENTER
摘要:Provided herein are compounds, such as compounds of Formulae (I), (I′), (XI), (XII), and (XIII), and pharmaceutically acceptable salts, solvates, tautomers, stereoisomers, and isotopically labeled derivatives thereof, and compositions, methods, uses, and kits thereof. The compounds provided herein are lipids useful for delivery of agents, including polynucleotides such as mRNA, for the treatment and/or prevention of various diseases and conditions (e.g., genetic diseases, proliferative diseases, hematological diseases, neurological diseases, liver diseases, spleen diseases, lung diseases, painful conditions, psychiatric disorders, musculoskeletal diseases, metabolic disorders, inflammatory diseases, and autoimmune diseases). Also provided herein are methods of synthesis of compounds of Formulae (I′), (XI), (XII), (XIII), and (VIII).

专利号:US-2022127649-A1
优先权日:2019-01-30
标题:Engineered cells for improved production of cannabinoids
发明人：NOBLE MICHAEL A; MOORE JONATHAN; LI JINGYI; LECHNER ANNA
权利人:GENOMATICA INC
摘要:The invention provides non-natural microbial organisms containing enzymatic pathways and/or metabolic modifications for enhancing synthesis of olivetolic acid, olivetolic acid derivatives and/or cannabinoids.

专利号:US-2014357576-A1
优先权日:2013-05-31
标题:Methods for enhancement of muscle protein synthesis
发明人：BREUILLE DENIS; STELLINGWERFF TRENT; MOORE DANIEL RYAN; OFFORD CAVIN ELIZABETH ANN; PHILLIPS STUART MARTIN
权利人:NESTEC SA
摘要:The present disclosure provides methods for enhancing muscle protein synthesis in an individual in need of same. Specifically, the present disclosure provides methods for enhancing muscle protein synthesis by enhancing myofibrillar muscle protein synthesis. The method includes administering to the individual a mixed macronutrient composition having (i) an amount of whey protein that is not capable of enhancing myofibrillar protein synthesis when ingested by itself and (ii) free leucine. The composition comprises at least about 5.0 g total leucine per dose.

专利号:US-2014294788-A1
优先权日:2013-03-26
标 题 :Methods for enhancing muscle protein synthesis following concurrent training
发明人：BAILEY DAVID MARK; ZALTAS ERIC SCOTT; MOORE DANIEL RYAN; STELLINGWERFF TRENT
权利人:NESTEC SA
摘要:The present disclosure provides methods for enhancing muscle protein synthesis following physical exertion. In a general embodiment, a method for enhancing muscle protein synthesis following physical exertion is provided and includes administering to an individual a composition comprising from about 15 to about 35 g protein immediately following concurrent training. Programs for enhancing muscle adaptation resulting from concurrent training are also provided. The programs include providing a composition comprising from about 15 to about 35 g protein; and providing guidelines for consumption including a recommendation of the amount of the composition to consume immediately following concurrent training.