CAS: 74936-71-3; 1,4-Dihydro-2,6-Dimethyl-4-(2'-Nitrophenyl)-Pyridine-3,5-Dicarboxylic Acid Monomethyl Ester

上下游产品

1,4-Dihydro-2,6-Dimethyl-3-Methoxycarbonyl-4-(2-Nitrophenyl)-5-(2-Cyanoethoxy)-Carbonyl-Pyridine 75150-43-5

📜β-氨基巴豆酸甲酯置于lithium Hydroxide Monohydrate体系中,用 乙醇 作为反应溶剂,化学反应 2.0H,反应生成 硝苯地平杂质h
参考文献:化合物及其作为l-型钙通道阻滞剂或/和乙酰 胆碱酯酶抑制剂的应用
标题:化合物及其作为l-型钙通道阻滞剂或/和乙酰 胆碱酯酶抑制剂的应用
摘要:本发明公开了化合物及其作为l-型钙通道阻滞剂或/和乙酰胆碱酯酶抑制剂的应用.100Nmol/l的本发明所述化合物对l-型钙通道的抑制率为8.71-35.77%,1000Nmol/l的本发明所述化合物对l-型钙通道的抑制率为26.43-83.54%,本发明所述化合物对乙酰胆碱酯酶活性的ic50为16-1470Nmol/l,可见,本发明所述化合物对l-型钙通道具有有效地阻滞作用,对乙酰胆碱酯酶具有明显的抑制作用,因此,本发明还提供所述化合物在制备治疗心血管疾病,中风或老年性痴呆药物中的应用.

专利信息

专利号:WO-9319076-A1
优先权日:1992-03-20
标题:θ6 METAL COMPLEXES OF 4-ARYL-1,4-DIHYDROPYRIDINES
发明人：NATALE NICHOLAS R; BITTERWOLF THOMAS E; HUBLER TIMOTHY
权利人:IDAHO RES FOUND
摘要:The present invention is directed to θ6 metal complexes of the arene group of 4-aryl-1,4-dihydropyridines. The 4-aryl-1,4-dihydropyridines are made according to the Hantzsch pyridine synthesis, and are then reacted with a Ï€ acid ligand-metal reagent to attach the metal in an θ6 fashion to the 6Ï€ electrons of the arene ring. The 4-aryl-1,4-dihydropyridine metal complexes are designed to provide useful spectroscopic information concerning the conformation of the 4-aryl-1,4-dihydropyridines and how such compounds interact with the calcium channel protein. Moreover, the 4-aryl-1,4-dihydropyridine metal complexes are robust calcium antagonists and compare to or exceed the biological activity of previously known calcium channel antagonists.

专利号:EP-1532110-B1
优先权日:2002-07-01
标题 :Industrial process for the synthesis of isobutyl methyl 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridine dicarboxylate (nisoldipine)

专利号:EP-1532110-A1
优先权日:2002-07-01
标 题:Industrial process for the synthesis of isobutyl methyl 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridine dicarboxylate (nisoldipine)

专利号:WO-2004002958-A1
优先权日:2002-07-01
标题 :Industrial process for the synthesis of isobutyl methyl 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridine dicarboxylate (nisoldipine)

专利号:US-5258519-A
优先权日:1990-11-13
标 题:Dihydropyridine vasodilators agents
发明人：WHEELER THOMAS N; KENAKIN TERRENCE P
权利人:GLAXO INC
摘要:Compounds of the following formula (I): (I) where R1 and R2 are alkyl or cycloalkyl, which may be substituted, R4 is aryl such as phenyl which may be substituted, L is a direct bond or an oxygen containing linking group, R is a hydrogen, alkyloxy, alkyl, halogen or haloalkyl and Het is a pyridinyl or pyridazinyl group. The compounds can be used antihypertensives or myocardial relaxants. Also part of the invention are pharmaceutical compositions, intermediates and methods of synthesis.

专利号:US-5100892-A
优先权日:1990-11-13
标 题 :Dihydropyridine vasodilator agents
发明人：WHEELER THOMAS N; KENAKIN TERRENCE P
权利人:GLAXO INC
摘要:Compounds of the following formula (I): (I) where R1 and R2 are alkyl or cycloalkyl, which may be substituted, R4 is aryl such as phenyl which may be substituted, L is a direct bond or an oxygen containing linking group, R is a hydrogen, alkyloxy, alkyl, halogen or haloalkyl and Het is a pyridinyl or pyridazinyl group. The compounds can be used antihypertensives or myocardial relaxants. Also part of the invention are pharmaceutical compositions, intermediates and methods of synthesis.