CAS: 6953-61-3; N-Hydroxy-1-Naphthamide

该化合物是一种六氟酸衍生物,其特点是其丙烯脊椎,这增强了其发泡特性.该化合物因其与金属离子的强烈亲近性而特别受到重视,使其在分析化学中有利于选择性金属提取和分离过程.其在酸性条件下的稳定性以及形成铁,铜和锌等过渡性金属稳定复合体的能力是主要优势. 此外,1-Naphtho氢氧酸因其与矿物表面的选择性互动而在浮转过程中发现了对氧化物的应用.该化合物在有机溶剂中定义明确的再活性和溶性进一步增强了其在合成和工业化学中的效用.

结构式图片

物理性质

MSDS等安全信息

欧盟法规

ECHA物质C&L通报

上下游产品

CAS号879-18-5 1-萘甲酰氯 | CAS号86-55-5 1-萘甲酸 | CAS号2459-24-7 1-萘甲酸甲酯 | CAS号134-32-7 1-萘胺 | CAS号607-56-7 N,N-二(1-萘基)尿素

合成工艺路线路线简述

    📜1-萘甲醇置于n-羟基丁二酰亚胺,碘苯二乙酸,羟胺体系中,用 乙腈,水 作为反应溶剂,化学反应 15.0H,以67%的收率获得产物1-萘羟肟酸
    参考文献:两步串联反应可直接从醇中制备异羟肟酸†
    标题:两步串联反应可直接从醇中制备异羟肟酸†
    摘要:已经开发了从醇类中首次合成异羟肟酸.苄醇和脂族醇均可被接受并用于该反应.该方法是经济的,环境友好的和高产率的.
    DOI:10.1039/c4Ob00693C

    海关参考信息

    专利信息


    专利号:US-6291709-B1
    优先权日:1998-12-28
    标题:Solid supported synthesis of hydroxamic acids
    发明人：GOLEBIOWSKI ADAM; KLOPFENSTEIN SEAN REES
    权利人:PROCTER & GAMBLE
    摘要:The subject invention involves processes for making hydroxamic acid compounds using a solid-support resin having an oxime moiety as the linking moiety of the resin, comprising the steps of (a) treating the resin with a carboxylic acid compound, such that it is attached to the resin by a condensation reaction between the oxime and carboxyl moieties; (b) optionally modifying the side chain; (c) cleaving a product from the resin by treating with O-tert-butyldimethylsilylhydroxylamine; (d) optionally modifying the side chain; and (e) optionally treating the resulting O-TBS-protected material with acid to produce an unprotected hydroxamic acid compound.

    专利号:CN-112439551-A
    优先权日:2020-11-02
    标 题:Synthesis process of a rare earth collector

    专利号:CN-112439551-B
    优先权日:2020-11-02
    标题:Synthesis process of a rare earth collector

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    主要参考文献


    1: Mao G, Hu S, Zhang Z, Wu P, Zhao X, Lin R, Liao W, Kang Y. Exosomal miR-95-5p regulates chondrogenesis and cartilage degradation via histone deacetylase 2/8. J Cell Mol Med. 2018 Jul 31. doi: 10.1111/jcmm.13808. [Epub ahead of print] doi: 10.1038/s41598-018-29463-x.
    3: Kolbinger FR, Koeneke E, Ridinger J, Heimburg T, Müller M, Bayer T, Sippl W, Jung M, Gunkel N, Miller AK, Westermann F, Witt O, Oehme I. The HDAC6/8/10 inhibitor TH34 induces DNA damage-mediated cell death in human high-grade neuroblastoma cell lines. Arch Toxicol. 2018 Aug;92(8):2649-2664. doi: 10.1007/s00204-018-2234-8. Epub 2018 Jun 9. doi: 10.1080/10799893.2018.1476541. Epub 2018 Jun 22. doi: 10.1021/acs.biochem.8b00367. Epub 2018 May 18.
    6: Zhao C, Zang J, Ding Q, Inks ES, Xu W, Chou CJ, Zhang Y. Discovery of meta-sulfamoyl N-hydroxybenzamides as HDAC8 selective inhibitors. Eur J Med Chem. 2018 Apr 25;150:282-291. doi: 10.1016/j.ejmech.2018.03.002. Epub 2018 Mar 6. doi: 10.1016/j.biopha.2018.02.071. Epub 2018 Feb 24. doi: 10.1016/j.ejmech.2017.10.076. Epub 2017 Oct 31.

    合成参考文献


    摘要:W. M. Wise and W. W. Brandt, J. Am. Chem. Soc. 77, 1058 (1955).
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