CAS: 6713-27-5; Moronic Acid

该化合物是一种主要来自Rhus javanica和其他植物树脂等自然来源的三叶类化合物,它具有显著的生物活动,包括抗微生物,抗炎和细胞毒性特性,使它成为药物和生化研究感兴趣的对象;该化合物的五环形结构有助于其稳定性和反应性,允许其在药物开发和有机合成方面的潜在应用;还研究甲酸在调控酶活动和细胞路径方面的作用;其纯度和结构完整性对于研究目的至关重要,确保可靠的实验结果;以标准化形式提供,作为学术和工业实验室的宝贵参考材料.

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10325-79-8 7020-50-0 98665-14-6

上下游产品

3β,28-dihydroxyoleanan-18(19)-eneMorolic acid N-(olean-3-oxo-18-en-28-oyl)-aminoundecanoic acid methyl ester N-(olean-3-oxo-18-en-28-oyl)-L-leucine methyl ester N-(olean-3β-hydroxy-18-en-28-oyl)-(1-hydroxymethyl-3-methyl)-butylamide

合成工艺路线路线简述

    📜3β,28-Dihydroxyoleanan-18(19)-Ene置于jones Reagent体系中,用 丙酮 作为反应溶剂,化学反应 4.0H,以78%的收率获得产物黄莲木酸
    参考文献:Synthesis Of Olean-18(19)-Ene Derivatives From Betulin
    标题:Synthesis Of Olean-18(19)-Ene Derivatives From Betulin
    摘要:The Rare Olean-18(19)-Ene Triterpenoids Moradiol And Moronic Acid Were Synthesized From Betulin,And Their Antiviral Properties Were Investigated.
    DOI:10.1134/s1068162009020125

    海关参考信息

    专利信息


    专利号:US-2014357576-A1
    优先权日:2013-05-31
    标题:Methods for enhancement of muscle protein synthesis
    发明人:BREUILLE DENIS; STELLINGWERFF TRENT; MOORE DANIEL RYAN; OFFORD CAVIN ELIZABETH ANN; PHILLIPS STUART MARTIN
    权利人:NESTEC SA
    摘要:The present disclosure provides methods for enhancing muscle protein synthesis in an individual in need of same. Specifically, the present disclosure provides methods for enhancing muscle protein synthesis by enhancing myofibrillar muscle protein synthesis. The method includes administering to the individual a mixed macronutrient composition having (i) an amount of whey protein that is not capable of enhancing myofibrillar protein synthesis when ingested by itself and (ii) free leucine. The composition comprises at least about 5.0 g total leucine per dose.

    专利号:WO-2015040533-A1
    优先权日:2013-09-19
    标题:Methods for enhancing muscle protein synthesis during energy deficit
    发明人:BAILEY DAVID MARK; ZALTAS ERIC SCOTT; STELLINGWERFF TRENT; MOORE DANIEL RYAN; HAWLEY JOHN ALAN; BURKE LOUISE MARY
    权利人:PREMIER NUTRITION CORP
    摘要:The present disclosure provides methods for enhancing muscle protein synthesis in an individual in need of same. Specifically, the present disclosure provides methods for enhancing muscle protein synthesis during periods of negative energy balance, or energy deficit. The methods include administering to an individual suffering from energy deficit a composition comprising protein in an amount from about 15 g to about 30 g during a time period selected from the group consisting of during exercise, post-exercise, and combinations thereof. The methods also include administering to an individual suffering from energy deficit a composition comprising protein during a time period selected from the group consisting of during exercise, post-exercise, and combinations thereof, wherein the protein is administered in a dose that is higher than doses typically recommended for individuals experiencing energy balance.

    专利号:US-2014294788-A1
    优先权日:2013-03-26
    标 题 :Methods for enhancing muscle protein synthesis following concurrent training
    发明人:BAILEY DAVID MARK; ZALTAS ERIC SCOTT; MOORE DANIEL RYAN; STELLINGWERFF TRENT
    权利人:NESTEC SA
    摘要:The present disclosure provides methods for enhancing muscle protein synthesis following physical exertion. In a general embodiment, a method for enhancing muscle protein synthesis following physical exertion is provided and includes administering to an individual a composition comprising from about 15 to about 35 g protein immediately following concurrent training. Programs for enhancing muscle adaptation resulting from concurrent training are also provided. The programs include providing a composition comprising from about 15 to about 35 g protein; and providing guidelines for consumption including a recommendation of the amount of the composition to consume immediately following concurrent training.

    专利号:WO-2014191856-A1
    优先权日:2013-05-31
    标 题:Methods for enhancement of muscle protein synthesis

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    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献

    [参考文献]: Ito J, Et Al. Anti-Aids Agents. 48.(1) Anti-Hiv Activity Of Moronic Acid Derivatives And The New Melliferone-Related Triterpenoid Isolated From Brazilian Propolis. J Nat Prod. 2001 Oct;64(10):1278-81.

    合成参考文献


    参考文献:10.1016/j.antiviral.2009.12.002
    摘要:Chang FR, Hsieh YC, Chang YF, Lee KH, Wu YC, Chang LK. Inhibition of the Epstein-Barr virus lytic cycle by moronic acid. Antiviral Res. 2010 Mar;85(3):490–5. doi: 10.1016/j.antiviral.2009.12.002.
    参考文献:10.1021/jm0601912
    摘要:Yu D, Sakurai Y, Chen CH, Chang FR, Huang L, Kashiwada Y, Lee KH. Anti-AIDS agents 69. Moronic acid and other triterpene derivatives as novel potent anti-HIV agents. J Med Chem. 2006 Sep 07;49(18):5462–9.
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